Anticancer Effects of Gold Nanoparticles by Inducing Apoptosis in Bladder Cancer 5637 Cells

Daei, Sajedeh; Ziamajidi, Nasrin; Abbasalipourkabir, Roghayeh; Khanaki, Korosh; Bahreini, Fatemeh

doi:10.1007/s12011-021-02895-9

Cited by 18 publications

(6 citation statements)

References 59 publications

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“…Combining CONPs with gemcitabine chemotherapy reduced the recurrence rate by synergistically exerting a more optimal effect than single agents ( 82 ). In addition, studies have also confirmed the killing effect of gold nanoparticles on different bladder cancer cell lines with the same effect ( 83 , 84 ).…”

Section: Inorganic Materials Nanocarriersmentioning

confidence: 74%

Current Researches on Nanodrug Delivery Systems in Bladder Cancer Intravesical Chemotherapy

Wang

et al. 2022

Front. Oncol.

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Bladder cancer is one of the most common malignant tumors in urinary system. Intravesical chemotherapy is a common adjuvant therapy after transurethral resection of bladder tumors. However, it has several disadvantages such as low drug penetration rate, short residence time, unsustainable action and inability to release slowly, thus new drug delivery and new modalities in delivery carriers need to be continuously explored. Nano-drug delivery system is a novel way in treatment for bladder cancer that can increase the absorption rate and prolong the duration of drug, as well as sustain the action by controlling drug release. Currently, nano-drug delivery carriers mainly included liposomes, polymers, and inorganic materials. In this paper, we reveal current researches in nano-drug delivery system in bladder cancer intravesical chemotherapy by describing the applications and defects of liposomes, polymers and inorganic material nanocarriers, and provide a basis for the improvement of intravesical chemotherapy drugs in bladder cancer.

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Section: Inorganic Materials Nanocarriersmentioning

confidence: 74%

Current Researches on Nanodrug Delivery Systems in Bladder Cancer Intravesical Chemotherapy

Wang

et al. 2022

Front. Oncol.

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“…The activation of the caspase-dependent process causes the plasma membrane to externalize. PI is an impenetrable dye that only stains the nucleus when the cell membrane integrity is compromised, which is associated with the late stages of apoptosis [ 67 ]. One of the most extensively employed methods for the detection of DNA damage in situ is TUNEL staining, which is performed in the TUNEL assay.…”

Section: Experimental Models For Evaluating Nanoparticle-based Formul...mentioning

confidence: 99%

Experimental Methods for the Biological Evaluation of Nanoparticle-Based Drug Delivery Risks

et al. 2023

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Many novel medical therapies use nanoparticle-based drug delivery systems, including nanomaterials through drug delivery systems, diagnostics, or physiologically active medicinal products. The approval of nanoparticles with advanced therapeutic and diagnostic potentials for applications in medication and immunization depends strongly on their synthesizing procedure, efficiency of functionalization, and biological safety and biocompatibility. Nanoparticle biodistribution, absorption, bioavailability, passage across biological barriers, and biodistribution are frequently assessed using bespoke and biological models. These methods largely rely on in vitro cell-based evaluations that cannot predict the complexity involved in preclinical and clinical studies. Therefore, assessing the nanoparticle risk has to involve pharmacokinetics, organ toxicity, and drug interactions manifested at multiple cellular levels. At the same time, there is a need for novel approaches to examine nanoparticle safety risks due to increased constraints on animal exploitation and the demand for high-throughput testing. We focus here on biological evaluation methodologies that provide access to nanoparticle interactions with the organism (positive or negative via toxicity). This work aimed to provide a perception regarding the risks associated with the utilization of nanoparticle-based formulations with a particular focus on assays applied to assess the cytotoxicity of nanomaterials.

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“…In addition, ROS production was significantly increased in cells treated with 25 and 50 μg/mL AuNPs. These AuNPs could promote the apoptosis of tumor cells by inducing Bax overexpression and downregulating Bcl-2 ( Daei et al, 2022 ).…”

Section: Gold Nanoparticles (Aunps)mentioning

confidence: 99%

Current applications of nanomaterials in urinary system tumors

Qian

Zhang

Yuan

et al. 2023

Front. Bioeng. Biotechnol.

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The development of nanotechnology and nanomaterials has provided insights into the treatment of urinary system tumors. Nanoparticles can be used as sensitizers or carriers to transport drugs. Some nanoparticles have intrinsic therapeutic effects on tumor cells. Poor patient prognosis and highly drug-resistant malignant urinary tumors are worrisome to clinicians. The application of nanomaterials and the associated technology against urinary system tumors offers the possibility of improving treatment. At present, many achievements have been made in the application of nanomaterials against urinary system tumors. This review summarizes the latest research on nanomaterials in the diagnosis and treatment of urinary system tumors and provides novel ideas for future research on nanotechnologies in this field.

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Anticancer Effects of Gold Nanoparticles by Inducing Apoptosis in Bladder Cancer 5637 Cells

Cited by 18 publications

References 59 publications

Current Researches on Nanodrug Delivery Systems in Bladder Cancer Intravesical Chemotherapy

Current Researches on Nanodrug Delivery Systems in Bladder Cancer Intravesical Chemotherapy

Experimental Methods for the Biological Evaluation of Nanoparticle-Based Drug Delivery Risks

Current applications of nanomaterials in urinary system tumors

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