Anticancer effects of curcumin in luminal B and HER2 breast cancer cell line models

Filippi, Alexandru; Măru, Nicoleta; Chifiriuc, Mariana Carmen; Grigore, Raluca; Ganea, Constanţa; Mocanu, Maria-Magdalena

doi:10.25083/rbl/24.1/168.175

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Therefore, the anticancer activity of curcumin is meditated via the ROS/JNK signaling pathway [ 106 ]. Although reports revealed that the growth inhibition of SKBR-3 cells induced by curcumin treatment was not associated with the suppression of MAPK P38 and ERK expression or phosphorylation [ 107 , 108 ], another study demonstrated that curcumin treatment on SKBR-3 cells resulted in the inhibition of ERK phosphorylation and was also able to sensitize hormone-independent HER2+ cells to TNF-related apoptosis inducing ligand (TRAIL) [ 109 ]. Furthermore, the increased phosphorylation of JNK found in curcumin-treated SKBR-3 cells led to the induction of JNK-dependent apoptosis [ 108 ].…”

Section: Curcumin: Impacts On Multiple Cellular Signaling Pathways In Hormone-independent Breast Cancermentioning

confidence: 99%

Curcumin: Modulator of Key Molecular Signaling Pathways in Hormone-Independent Breast Cancer

Farghadani

Naidu

2021

Cancers

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Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among women worldwide. Despite the overall successes in breast cancer therapy, hormone-independent HER2 negative breast cancer, also known as triple negative breast cancer (TNBC), lacking estrogens and progesterone receptors and with an excessive expression of human epidermal growth factor receptor 2 (HER2), along with the hormone-independent HER2 positive subtype, still remain major challenges in breast cancer treatment. Due to their poor prognoses, aggressive phenotype, and highly metastasis features, new alternative therapies have become an urgent clinical need. One of the most noteworthy phytochemicals, curcumin, has attracted enormous attention as a promising drug candidate in breast cancer prevention and treatment due to its multi-targeting effect. Curcumin interrupts major stages of tumorigenesis including cell proliferation, survival, angiogenesis, and metastasis in hormone-independent breast cancer through the modulation of multiple signaling pathways. The current review has highlighted the anticancer activity of curcumin in hormone-independent breast cancer via focusing on its impact on key signaling pathways including the PI3K/Akt/mTOR pathway, JAK/STAT pathway, MAPK pathway, NF-ĸB pathway, p53 pathway, and Wnt/β-catenin, as well as apoptotic and cell cycle pathways. Besides, its therapeutic implications in clinical trials are here presented.

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Section: Curcumin: Impacts On Multiple Cellular Signaling Pathways In Hormone-independent Breast Cancermentioning

confidence: 99%

Curcumin: Modulator of Key Molecular Signaling Pathways in Hormone-Independent Breast Cancer

Farghadani

Naidu

2021

Cancers

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“…Plant products are available and affordable sources of biologically active agents that may have dissimilar mechanisms of action as compared with conventional drugs [ 23 , 24 , 25 , 26 ] and can represent foundations for the development of new medications for diseases like cancer [ 27 , 28 , 29 , 30 ] and microbial infection [ 31 , 32 , 33 , 34 , 35 ]. Therefore, new natural drugs can be advanced from plant essential oils and extracts as no microorganism resistance or adaption to these natural drugs has been demonstrated in recent years [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Thin Coatings Containing Anthriscus sylvestris Extract with Dual Bioactivity

Neguț

Grumezescu

et al. 2020

Molecules

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Plant extracts are highly valuable pharmaceutical complexes recognized for their biological properties, including antibacterial, antifungal, antiviral, antioxidant, anticancer, and anti-inflammatory properties. However, their use is limited by their low water solubility and physicochemical stability. In order to overcome these limitations, we aimed to develop nanostructured carriers as delivery systems for plant extracts; in particular, we selected the extract of Anthriscus sylvestris (AN) on the basis of its antimicrobial effect and antitumor activity. In this study, AN-extract-functionalized magnetite (Fe3O4@AN) nanoparticles (NPs) were prepared by the co-precipitation method. The purpose of this study was to synthesize and investigate the physicochemical and biological features of composite coatings based on Fe3O4@AN NPs obtained by matrix-assisted pulsed laser evaporation technique. In this respect, laser fluence and drop-casting studies on coatings were performed. The physical and chemical properties of laser-synthesized coatings were investigated by scanning electron microscopy, while Fourier transform infrared spectroscopy comparative analysis was used for determining the chemical structure and functional integrity. Relevant data regarding the presence of magnetic nanoparticles as the only crystalline phase and the size of nanoparticles were obtained by transmission electron microscopy. The in vitro toxicity assessment of the Fe3O4@AN showed significant cytotoxic activity against human adenocarcinoma HT-29 cells after prolonged exposure. Antimicrobial results demonstrated that Fe3O4@AN coatings inhibit microbial colonization and biofilm formation in clinically relevant bacteria species and yeasts. Such coatings are useful, natural, and multifunctional solutions for the development of tailored medical devices and surfaces.

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Cytotoxicity evaluation of curcumin-loaded affibody-decorated liposomes against breast cancerous cell lines

Nasery

Mandegary

Eslaminejad

et al. 2020

Journal of Liposome Research

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Anticancer effects of curcumin in luminal B and HER2 breast cancer cell line models

Cited by 3 publications

References 10 publications

Curcumin: Modulator of Key Molecular Signaling Pathways in Hormone-Independent Breast Cancer

Curcumin: Modulator of Key Molecular Signaling Pathways in Hormone-Independent Breast Cancer

Nanostructured Thin Coatings Containing Anthriscus sylvestris Extract with Dual Bioactivity

Cytotoxicity evaluation of curcumin-loaded affibody-decorated liposomes against breast cancerous cell lines

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