Anticancer effect of propranolol on diethylnitrosamine‐induced hepatocellular carcinoma rat model
Yomna M. Tamim,
Ahmed A. Nagy,
Ahmed M. Abdellah
et al.
Abstract:BackgroundHepatocellular carcinoma (HCC) is the most widespread type of primary liver cancer. Diethylnitrosamine (DEN), a hepatotoxic hepatocarcinogenic compound, is used to induce HCC in animal models. The non‐selective β‐blocker propranolol demonstrated antiproliferative activity in many cancer types.ObjectiveThis investigation aimed to evaluate the anticancer effect of propranolol against DEN‐induced HCC in rats.MethodsThirty adult male rats were divided into the following groups: Group I (C, control), Grou… Show more
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