Anticancer Effect of Active Component of Astragalus Membranaceus Combined with Olaparib on Ovarian Cancer Predicted by Network-Based Pharmacology

Liu, Yang; Guo, Zhongkun; Lang, Fangfang; Li, Jie; Jiang, Jie

doi:10.1007/s12010-023-04462-5

Cited by 3 publications

(2 citation statements)

References 56 publications

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“…Recently, Liu Yang et al discovered that quercetin from Astragalus membranaceus inhibits the proliferation and migration of ovarian cancer cells by targeting tumor proteins p53, MYC, vascular endothelial growth factor, phosphatase and tensin homolog, AKT serine/threonine kinase, and Cyclin D1. Meanwhile, combining quercetin and olaparib synergistically enhances the anticancer effects against ovarian cancer ( Liu et al, 2023 ). According to reports, tanshinone IIA, a compound derived from Salvia miltiorrhiza, exerts inhibitory effects on the malignant proliferation of prostate cancer by suppressing multiple pathways ( Li et al, 2022 ).…”

Section: Summary Of Main Findingsmentioning

confidence: 99%

Analyzing the research landscape: Mapping frontiers and hot spots in anti-cancer research using bibliometric analysis and research network pharmacology

Han,

Li,

et al. 2023

Front. Pharmacol.

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Introduction: Network pharmacology has emerged as a forefront and hotspot in anti-cancer. Traditional anti-cancer drugs are limited by the paradigm of “one cancer, one target, one drug,” making it difficult to address the challenges of recurrence and drug resistance. However, the main advantage of network pharmacology lies in its approach from the perspective of molecular network relationships, employing a “one arrow, multiple targets” strategy, which provides a novel pathway for developing anti-cancer drugs. This study employed a bibliometric analysis method to examine network pharmacology’s application and research progress in cancer treatment from January 2008 to May 2023. This research will contribute to revealing its forefront and hotspots, offering new insights and methodologies for future investigations.Methods: We conducted a literature search on network pharmacology research in anti-cancer (NPART) from January 2008 to May 2023, utilizing scientific databases such as Web of Science Core Collection (WoSCC) and PubMed to retrieve relevant research articles and reviews. Additionally, we employed visualization tools such as Citespace, SCImago Graphica, and VOSviewer to perform bibliometric analysis.Results: This study encompassed 3,018 articles, with 2,210 articles from WoSCC and 808 from PubMed. Firstly, an analysis of the annual national publication trends and citation counts indicated that China and the United States are the primary contributing countries in this field. Secondly, the recent keyword analysis revealed emerging research hotspots in “tumor microenvironment,” “anti-cancer drugs,” and “traditional Chinese medicine (TCM). “ Furthermore, the literature clustering analysis demonstrated that “calycosin,” “molecular mechanism,” “molecular docking,” and “anti-cancer agents” were widely recognized research hotspots and forefront areas in 2023, garnering significant attention and citations in this field. Ultimately, we analyzed the application of NPART and the challenges.Conclusion: This study represents the first comprehensive analysis paper based on bibliometric methods, aiming to investigate the forefront hotspots of network pharmacology in anti-cancer research. The findings of this study will facilitate researchers in swiftly comprehending the current research trends and forefront hotspots in the domain of network pharmacology in cancer research.

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Section: Summary Of Main Findingsmentioning

confidence: 99%

Analyzing the research landscape: Mapping frontiers and hot spots in anti-cancer research using bibliometric analysis and research network pharmacology

Han,

Li,

et al. 2023

Front. Pharmacol.

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“…The roots (Radix Astragali) are rich in bioactive compounds (esp. triterpene glycosides, flavonoids, saponins and alkaloids; (Zhang et al 2021), and are recognised for their immunomodulatory (Qader et al 2021), antioxidant (Cui et al 2022), antibacterial (Samuel et al 2021), hepatoprotective (Chen et al 2023b) diuretic (Jia et al 2021), antidiabetic (Chen et al 2022), anticancer (Liu et al 2023), and anti-inflammatory properties (Chen et al 2023a), making it a staple in traditional medicine (Md Ashif Ikbal et al 2022). Nevertheless, there is an inherent need to increase productivity and phytochemical content to meet the increasing demands of the pharmaceutical and nutraceutical industries (Wu et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Exploring in vitro Oryzalin-Induced Polyploidy in Astragalus membranaceus: Implications for Gene Expression

Šenkyřík,

Navrátilová,

Fišerová

et al. 2024

Preprint

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This study investigates the effects of artificial in vitro polyploidisation of Astragalus membranaceus, focusing specifically on gene expression and metabolic pathway associated with the biosynthesis of calycosin and calycosin-7-O-β-D-glucoside. Using oryzalin as an antimitotic agent, we have systematically investigated different genotypic lines, under both in vitro and ex vitro conditions. Amid cases of reduced gene expression in certain lines, results showed a significant upregulation in specific lines, particularly in genotypes 16, 54, and 74. Genotype 54 showed an exceptional response, manifesting a statistically significant upregulation in all investigated genes studied under in vitro conditions (i.e. AmPAL, AmC4H and AmI3′H). Interestingly, even under ex vitro conditions after two years of greenhouse cultivation, certain lines showed significant variations in gene expression. Despite the loss of tetraploidy, genotype 16 exhibited the highest expression levels among the examined genotypes, with statistically significant upregulation of both the AmPAL and AmC4H genes. In addition, the tetraploid genotype 74 showed a significant upregulation of the AmI3′H gene and a concomitant downregulation of the AmC4H gene. These results highlight the complex regulatory mechanisms affected by the polyploidisation of Astragalus membranaceus and provide promising avenues for manipulating gene expression to enhance the production of pharmacologically significant compounds.

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Exploring in vitro oryzalin-induced polyploidy in Astragalus membranaceus: implications for gene expression

Šenkyřík,

Navrátilová,

Fišerová

et al. 2024

Plant Cell Tiss Organ Cult

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This study investigates the effects of artificial in vitro polyploidisation of Astragalus membranaceus, focusing specifically on gene expression and metabolic pathway associated with the biosynthesis of calycosin and calycosin-7-O-β-D-glucoside. Using oryzalin as an antimitotic agent, we have systematically investigated different genotypic lines, under both in vitro and ex vitro conditions. Amid cases of reduced gene expression in certain lines, results showed a significant upregulation in specific lines, particularly in genotypes 16, 54, and 74. Genotype 54 showed an exceptional response, manifesting a statistically significant upregulation in all investigated genes studied under in vitro conditions (i.e. AmPAL, AmC4H and AmI3′H). Interestingly, even under ex vitro conditions after two years of greenhouse cultivation, certain lines showed significant variations in gene expression. The genotype 16, although no longer tetraploid, exhibited the highest expression levels among the examined genotypes, with statistically significant upregulation of both the AmPAL and AmC4H genes. In addition, the induced autotetraploid genotype 74 showed a significant upregulation of the AmI3′H gene and a concomitant downregulation of the AmC4H gene. These results highlight the complex regulatory mechanisms affected by the polyploidisation of A. membranaceus and provide promising avenues for manipulating gene expression to enhance the production of pharmacologically significant compounds. Key message This study investigates the effects of artificial polyploidisation on gene expression of Astragalus membranaceus, suggesting diverse regulatory influences for potential plant bioactive compound production.

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Anticancer Effect of Active Component of Astragalus Membranaceus Combined with Olaparib on Ovarian Cancer Predicted by Network-Based Pharmacology

Cited by 3 publications

References 56 publications

Analyzing the research landscape: Mapping frontiers and hot spots in anti-cancer research using bibliometric analysis and research network pharmacology

Analyzing the research landscape: Mapping frontiers and hot spots in anti-cancer research using bibliometric analysis and research network pharmacology

Exploring in vitro Oryzalin-Induced Polyploidy in Astragalus membranaceus: Implications for Gene Expression

Exploring in vitro oryzalin-induced polyploidy in Astragalus membranaceus: implications for gene expression

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