Anticancer chemotherapy in teenagers and young adults: managing long term side effects

Ahmad, Saif; Reinius, Marika; Hatcher, Helen; Ajithkumar, TV

doi:10.1136/bmj.i4567

Cited by 67 publications

(53 citation statements)

References 48 publications

(40 reference statements)

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“…The prevalence of late effects in our study (28%) was lower compared with other studies. 4 This might be due to self-report of late effects and survivors not being aware of health problems being late sequelae of their cancer diagnosis and treatment.…”

Section: Discussionmentioning

confidence: 99%

“…We will focus on survivors having been diagnosed at age 16 to 25 covering an age range full of psychosocial developments. Therefore, late effects may be different from those in cancer survivors diagnosed at a younger or older age, especially regarding psychosocial difficulties, which are a major concern for long‐term AYA cancer survivors …”

Section: Introductionmentioning

confidence: 99%

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The long‐term impact of cancer: Evaluating psychological distress in adolescent and young adult cancer survivors in Switzerland

et al. 2019

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Objectives Adolescents and young adults (AYAs) are diagnosed with cancer during a critical life period full of psychosocial challenges. They may experience a significant impact of the cancer diagnosis on their psychological health, also in the long term. We aimed to (a) evaluate psychological distress in AYA cancer survivors and compare levels of distress with controls and (b) describe socio‐demographic and cancer‐related characteristics associated with psychological distress. Methods We sent a questionnaire to AYA cancer survivors (aged 16‐25 y at diagnosis, survived ≥5 y) registered in the Cancer Registry Zurich and Zug, Switzerland. Psychological distress was measured using the Brief Symptom Inventory‐18 (BSI‐18) assessing anxiety, depression, and somatization and a global severity index (GSI) (cutoff score indicating psychological distress: T ≥ 57). Distress levels were compared between survivors and controls. We used logistic regression to determine associations of socio‐demographic and cancer‐related characteristics with distress. Results Of 160 AYA cancer survivors, 34 (21%) reported being distressed (27% in women, 17% in men; P = 0.129). Compared with controls, survivors did not report higher levels of distress (all P values > 0.05). Survivors with migration background and survivors with late effects reported higher levels on GSI, somatization, and anxiety. Higher levels of depression were associated with being female, not being in a partnership, and having late effects. Conclusions A substantial subgroup of AYA cancer survivors reported psychological distress. Systematically screening for distress and providing psychological follow‐up for survivors at risk may help to provide adequate psychological support.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The long‐term impact of cancer: Evaluating psychological distress in adolescent and young adult cancer survivors in Switzerland

et al. 2019

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“…Renal damage may result from nephrotoxic chemotherapy, such as the platinum based drugs, as well as from tumour lysis syndrome that may complicate the treatment of some high grade lymphomas. Fertility may be reduced 33. Where relevant, male patients are offered sperm banking and female patients should be offered urgent consultation with a fertility specialist.…”

Section: What Are the Complications Of Chemotherapy?mentioning

confidence: 99%

Non-Hodgkin lymphoma

Al-Naeeb

Ajithkumar

Behan

et al. 2018

BMJ

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“…The risk of developing MN is higher in the first few years after chemotherapy. Furthermore, chemotherapeutic drugs may also disrupt the normal psychological state of patients in certain cases [43,44].…”

Section: Chemotherapeutic-associated Toxicity In Breast Cancer Treatmentmentioning

confidence: 99%

Herbal Remedies for Breast Cancer Prevention and Treatment

Laskar¹,

Lourembam²,

Mazumder³

2020

Medicinal Plants - Use in Prevention and Treatment of Diseases

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Breast cancer is among the most common type of cancer in women around the globe. Prevention of breast cancer is better than its treatment. Because of the molecular variation and complexity underlying breast cancer occurrence, its treatment by using chemotherapy and/or radiotherapy is very complicated and often leads to undesirable side effects. Plants and their extracts have been used for centuries for the treatment of almost every disease and breast cancer is not an exception. Herbal products can be trusted for cancer treatment because of their low toxicity. Besides, herbal remedies are easily accepted by the majority of woman suffering from breast cancer because of their easy availability and affordability. In the last decade, a large number of plants and their compounds were reported to show promising anticancerous effects against breast cancer cells in both in vivo and in vitro models. However, their beneficial effects on breast cancer treatment are still doubtful due to the lack of randomized clinical trials. This chapter is dedicated to reporting the potential of some herbal products for the prevention and/or treatment of breast cancer. Besides, it focused on the anticarcinogenic mechanism of those phytocompounds to report their potential chemotherapeutic role.

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Anticancer chemotherapy in teenagers and young adults: managing long term side effects

Cited by 67 publications

References 48 publications

The long‐term impact of cancer: Evaluating psychological distress in adolescent and young adult cancer survivors in Switzerland

The long‐term impact of cancer: Evaluating psychological distress in adolescent and young adult cancer survivors in Switzerland

Non-Hodgkin lymphoma

Herbal Remedies for Breast Cancer Prevention and Treatment

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