Anticancer Biosurfactant-Loaded PLA–PEG Nanoparticles Induce Apoptosis in Human MDA-MB-231 Breast Cancer Cells

Wadhawan, Aishani; Singh, J. S.; Sharma, Himani; Handa, S. M.; Singh, Gurpal; Kumar, Ravinder; Barnwal, Ravi Pratap; Kaur, Indu Pal; Chatterjee, Mary

doi:10.1021/acsomega.1c06338

Cited by 19 publications

(17 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wadhawan et al conjugated the folate ligand with the PLA–PEG copolymer to obtain the active targeting of the system in the MDAMB-231 cancer cells. Folic acid-conjugated nanoparticles were reported to actively target the cells and deliver therapeutic agent to the target site more efficiently [ 49 ].…”

Section: Resultsmentioning

confidence: 99%

Development and Characterization of Folic Acid-Conjugated Amodiaquine-Loaded Nanoparticles–Efficacy in Cancer Treatment

2023

View full text Add to dashboard Cite

The objective of this study was to construct amodiaquine-loaded, folic acid-conjugated polymeric nanoparticles (FA-AQ NPs) to treat cancer that could be scaled to commercial production. In this study, folic acid (FA) was conjugated with a PLGA polymer followed by the formulation of drug-loaded NPs. The results of the conjugation efficiency confirmed the conjugation of FA with PLGA. The developed folic acid-conjugated nanoparticles demonstrated uniform particle size distributions and had visible spherical shapes under transmission electron microscopy. The cellular uptake results suggested that FA modification could enhance the cellular internalization of nanoparticulate systems in non-small cell lung cancer, cervical, and breast cancer cell types. Furthermore, cytotoxicity studies showed the superior efficacy of FA-AQ NPs in different cancer cells such as MDAMB-231 and HeLA. FA-AQ NPs had better anti-tumor abilities demonstrated via 3D spheroid cell culture studies. Therefore, FA-AQ NPs could be a promising drug delivery system for cancer therapy.

show abstract

Section: Resultsmentioning

confidence: 99%

Development and Characterization of Folic Acid-Conjugated Amodiaquine-Loaded Nanoparticles–Efficacy in Cancer Treatment

2023

View full text Add to dashboard Cite

show abstract

“…Moreover, NCTD-PLGA nanoparticles had no obvious side effects at LD 50 dose level [(66.7 ± 3.9) mg/kg], while NCTD induced severe prostration, apathy, and catatonia at LD 50 dose level [(25.4 ± 1.9) mg/kg]. PLA-polyethylene glycol (PLA-PEG) amphiphilic block copolymer as a drug carrier could also increase the drug loading of hydrophobic drugs, reduce the burst effect, extend blood circulation time and improve the bioavailability of drugs [ 67 ]. Ren et al [ 68 ] prepared a NCTD nanoparticle using PLA-PEG as carrier by phase separation method.…”

Section: Passive Targeted Drug Delivery Systemsmentioning

confidence: 99%

Review targeted drug delivery systems for norcantharidin in cancer therapy

et al. 2022

View full text Add to dashboard Cite

Norcantharidin (NCTD) is a demethylated derivative of cantharidin (CTD), the main anticancer active ingredient isolated from traditional Chinese medicine Mylabris. NCTD has been approved by the State Food and Drug Administration for the treatment of various solid tumors, especially liver cancer. Although NCTD greatly reduces the toxicity of CTD, there is still a certain degree of urinary toxicity and organ toxicity, and the poor solubility, short half-life, fast metabolism, as well as high venous irritation and weak tumor targeting ability limit its widespread application in the clinic. To reduce its toxicity and improve its efficacy, design of targeted drug delivery systems based on biomaterials and nanomaterials is one of the most feasible strategies. Therefore, this review focused on the studies of targeted drug delivery systems combined with NCTD in recent years, including passive and active targeted drug delivery systems, and physicochemical targeted drug delivery systems for improving drug bioavailability and enhancing its efficacy, as well as increasing drug targeting ability and reducing its adverse effects. Graphical Abstract

show abstract

“…Therefore, applying biosurfactants to alleviate human diseases is less expensive and free from the possible harmful effects of alternative treatments. [22,24,25] The current review provided a synopsis of the most recent developments in microbial biosurfactants and the limiting factors responsible for biosurfactant production. Furthermore, we will discuss the possible uses of biosurfactants in sustainable farming, especially in boosting soil health or managing phytopathogens, and in the biopharmaceutical sector as an antibacterial or antioxidant molecule.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, biosurfactant molecules are widely used in modern pharmaceutical industries as raw materials, antioxidants, antibacterial and anticancer agents, anticancer agents, emulsifying agents, and dispersion agents. Therefore, applying biosurfactants to alleviate human diseases is less expensive and free from the possible harmful effects of alternative treatments [22,24,25] . The current review provided a synopsis of the most recent developments in microbial biosurfactants and the limiting factors responsible for biosurfactant production.…”

Section: Introductionmentioning

confidence: 99%

Prospects of Microbial Bio‐surfactants To Endorse Prolonged Conservation in the Pharmaceutical and Agriculture Industries

Karnwal

2023

ChemistrySelect

View full text Add to dashboard Cite

Chemical surfactants have raised concerns due to their negative impact on ecosystems, prompting the search for ecofriendly alternatives. Biosurfactants derived from microorganisms offer a promising solution. These biomolecules are less harmful and can replace toxic pesticide surfactants. Biosurfactants have shown potential in agriculture for food digestion, crop protection, soil fertility, disease management, antibacterial properties, and biofilm prevention. They eliminate plantpathogens and improve nutrient availability, supporting plantgrowth. Rhamnolipids, produced by Pseudomonas, reduce surface tension, are used as wetting agents and emulsifiers in agriculture, and antimicrobial and anti-inflammatory medications. Surfactin, a biosurfactant from Bacillus subtilis, improves plant development, controls plant diseases, and fights pathogens and diseases. Candida bombicola yeast produces sopho-rolipids, biodegradable surfactants with antibacterial, anticancer, and anti-inflammatory properties. Pseudozyma yeast produces mannosylerythritol lipids (MELs), which biocontrol fungus and have antibacterial, anticancer, and immunomodulatory activities. Biosurfactants also hold potential in pharmaceuticals, functioning as antioxidants, exhibiting antibacterial and anticancer activities, and acting as drug-delivery systems. However, challenges in biosurfactant production include varying research methods, limited production organism sources, and cost implications for large-scale manufacturing. This minireview explores microbiologically produced biosurfactants, their regulatory parameters, their applications in optimizing soil health and controlling plant infections, and their potential roles in the pharmaceutical sector.* Ability to tolerate high temperatures, * Ability to tolerate variation in pH, * Ability to tolerate saline environment, * Biodegradable character, * Low or non-toxic nature, and * Effective selectivity.Generally, biosurfactants are amphipathic molecules characterized by hydrophobic and hydrophilic components. Generally, the hydrophobic component consists of a very long chain of fatty acids connected. The hydrophilic component comprises positively, negatively, or amphoterically charged ions. In contrast to their chemical analogs, biosurfactants are often categorized by their CMC concentration, low or high molecular weight, the microorganism type that produce biosurfactant, and their mode of action. Low molecular weight biosurfactants are most frequently reported as glycolipids, phospholipids, and [a]

show abstract

Anticancer Biosurfactant-Loaded PLA–PEG Nanoparticles Induce Apoptosis in Human MDA-MB-231 Breast Cancer Cells

Cited by 19 publications

References 38 publications

Development and Characterization of Folic Acid-Conjugated Amodiaquine-Loaded Nanoparticles–Efficacy in Cancer Treatment

Development and Characterization of Folic Acid-Conjugated Amodiaquine-Loaded Nanoparticles–Efficacy in Cancer Treatment

Review targeted drug delivery systems for norcantharidin in cancer therapy

Prospects of Microbial Bio‐surfactants To Endorse Prolonged Conservation in the Pharmaceutical and Agriculture Industries

Contact Info

Product

Resources

About