Anticancer, Antioxidant and Cytotoxic Potential of Thymol <i>in vitro</i> Brain Tumor Cell Model

Aydın, Elanur; Türkez, Hasan; Taşdemir, Şener; Hacımüftüoğlu, Fazil

doi:10.2174/1871524916666160823121854

Cited by 17 publications

(11 citation statements)

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“…This report clearly revealed that thymol is a potent anticancer and antiproliferative agent (Aydin et al, 2016). …”

Section: Thymol In Cancer Cellsmentioning

confidence: 79%

“…Thymol (400 mg/L) decreased cell proliferation in cultured neuroblastoma cells (N2a cells) whereas thymol (19, 25, and 50 mg/L) increased the total antioxidant capacity in rat neurons but not in N2a cells. This report clearly revealed that thymol is a potent anticancer and antiproliferative agent ( Aydin et al, 2016 ).…”

Section: Thymol In Cancer Cellsmentioning

confidence: 79%

“…Thymol (200 μM) potentiated the release of (3H)-GABA (EC 50 = 170 μM/L) probably by its antagonistic effect on GABA b autoreceptors in rat neocortical slices ( Parker et al, 2014 ). Thymol (0–400 mg/L) was shown to trigger cytotoxicity in N2a neuroblastoma cells ( Aydin et al, 2016 ).…”

Section: Thymol In Models Of Cns Diseasesmentioning

confidence: 99%

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Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

et al. 2017

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Thymol, chemically known as 2-isopropyl-5-methylphenol is a colorless crystalline monoterpene phenol. It is one of the most important dietary constituents in thyme species. For centuries, it has been used in traditional medicine and has been shown to possess various pharmacological properties including antioxidant, free radical scavenging, anti-inflammatory, analgesic, antispasmodic, antibacterial, antifungal, antiseptic and antitumor activities. The present article presents a detailed review of the scientific literature which reveals the pharmacological properties of thymol and its multiple therapeutic actions against various cardiovascular, neurological, rheumatological, gastrointestinal, metabolic and malignant diseases at both biochemical and molecular levels. The noteworthy effects of thymol are largely attributed to its anti-inflammatory (via inhibiting recruitment of cytokines and chemokines), antioxidant (via scavenging of free radicals, enhancing the endogenous enzymatic and non-enzymatic antioxidants and chelation of metal ions), antihyperlipidemic (via increasing the levels of high density lipoprotein cholesterol and decreasing the levels of low density lipoprotein cholesterol and low density lipoprotein cholesterol in the circulation and membrane stabilization) (via maintaining ionic homeostasis) effects. This review presents an overview of the current in vitro and in vivo data supporting thymol’s therapeutic activity and the challenges concerning its use for prevention and its therapeutic value as a dietary supplement or as a pharmacological agent or as an adjuvant along with current therapeutic agents for the treatment of various diseases. It is one of the potential candidates of natural origin that has shown promising therapeutic potential, pharmacological properties and molecular mechanisms as well as pharmacokinetic properties for the pharmaceutical development of thymol.

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“…This report clearly revealed that thymol is a potent anticancer and antiproliferative agent (Aydin et al, 2016). …”

Section: Thymol In Cancer Cellsmentioning

confidence: 79%

Section: Thymol In Cancer Cellsmentioning

confidence: 79%

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Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

et al. 2017

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“…From nine plant species only C. armena and T. transcaucasicus showed comparatively strong antioxidant, as well as high‐to‐moderate cytotoxic activities. Some of identified main terpenes and polyphenols, such as β‐caryophyllene, kaempferol, quercitrin, apigenin, hyperoside and ursolic acid in C. armena and borneol, carvacrol, thymol, linalool, geraniol, 1,8‐cineole, rosmarinic acid, quercetin and caffeic acid in T. transcaucasicus were found to have antioxidant and cytotoxic activities. It should also be mentioned that borneol, linalool and rosmarinic acid, like plant extracts of C. armena and T. transcaucasicus in this study, showed similar cytotoxic activity against HepG2 cell lines.…”

Section: Discussionmentioning

confidence: 99%

Caucasian endemic medicinal and nutraceutical plants: in-vitro antioxidant and cytotoxic activities and bioactive compounds

Manukyan

Lumlerdkij

Heinrich

2019

Journal of Pharmacy and Pharmacology

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Objectives In order to assess traditional claims about the therapeutic potential of Caucasian endemic medicinal plants and to select plants for phytochemical research, nine plant species were selected and assessed for their in-vitro antioxidant and cytotoxic activities. The metabolite profiles of some priority plants were analysed. Methods Antioxidant effects were assessed using the 2,2 0 -azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) system, lipid peroxidation and Folin-Ciocalteu methods. Cytotoxic activities were examined against human liver cancer cells (HepG2) using the Alamar Blue assay. Terpenoids of selected species were analysed by GC and GC-MS. Polyphenols were separated by HPLC. Key findings Thymus transcaucasicus, Heracleum transcaucasicum, Ribes armenum, Crataegus armena showed most promising antioxidant activity in ABTS model system. Moreover, Rubus takhtadjanii, C. armena, T. transcaucasicus showed a high level of antioxidant activity by inhibiting lipid peroxidation. C. armena and T. transcaucasicus expressed high-to-moderate cytotoxicity against HepG2 cells. The main terpenoids and polyphenols of Centaurea hajastana, C. armena and T. transcaucasicus were quantified. Conclusions This study provides in-vitro data relevant for assessing the use of Caucasian endemic medicinal plants, most importantly C. armena and T. transcaucasicus as traditional antioxidant supplements and potential anticancer remedies. Metabolite profiles of some lead plants showed the nature of bioactive compounds of medical interest.

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“…Thymol has demonstrated antioxidant effects in mouse neuron cultures (10, 25, and 50 mg/L) [266], and presents excellent hydroxyl radical elimination capacity [267]. Thymol increases antioxidant enzyme levels, for example SOD, GPx, CAT, and GST, and non-enzymatic antioxidants such as vitamins C and E [268].…”

Section: Thymolmentioning

confidence: 99%

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

et al. 2019

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Epilepsy is a most disabling neurological disorder affecting all age groups. Among the various mechanisms that may result in epilepsy, neuronal hyperexcitability and oxidative injury produced by an excessive formation of free radicals may play a role in the development of this pathology. Therefore, new treatment approaches are needed to address resistant conditions that do not respond fully to current antiepileptic drugs. This paper reviews studies on the anticonvulsant activities of essential oils and their chemical constituents. Data from studies published from January 2011 to December 2018 was selected from the PubMed database for examination. The bioactivity of 19 essential oils and 16 constituents is described. Apiaceae and Lamiaceae were the most promising botanical families due to the largest number of reports about plant species from these families that produce anticonvulsant essential oils. Among the evaluated compounds, β-caryophyllene, borneol, eugenol and nerolidol were the constituents that presented antioxidant properties related to anticonvulsant action. These data show the potential of these natural products as health promoting agents and use against various types of seizure disorders. Their properties on oxidative stress may contribute to the control of this neurological condition. However, further studies on the toxicological profile and mechanism of action of essential oils are needed.

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Anticancer, Antioxidant and Cytotoxic Potential of Thymol in vitro Brain Tumor Cell Model

Abstract: In a conclusion, these results confirm that THY may have antiproliferative potential against brain tumor cells involving oxidative alteration.

Cited by 17 publications

References 0 publications

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

Caucasian endemic medicinal and nutraceutical plants: in-vitro antioxidant and cytotoxic activities and bioactive compounds

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

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