Anticancer, antioxidant, ameliorative and therapeutic properties of kaempferol

Shahbaz, Muhammad; Imran, Muhammad; Alsagaby, Suliman A.; Naeem, Hammad; Abdulmonem, Waleed Al; Hussain, Muzzamal; Abdelgawad, Mohamed A.; El‐Ghorab, Ahmed H.; Ghoneim, Mohammed M.; El‐Sherbiny, Mohamed; Atoki, Ayomide Victor; Awuchi, Chinaza Godswill

doi:10.1080/10942912.2023.2205040

Cited by 28 publications

(10 citation statements)

References 62 publications

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“…ROS reduction occurs by inducing phase 2 enzymes and altering signal transduction pathways. These flavonoids have been shown to inhibit the NF-κB transcription factor, stimulating the Nrf2 transcriptional pathway and restoring redox homeostasis in cells, contributing to cancer prevention through their antioxidant and anti-inflammatory effects [ 49 ]. Studies conducted by Kluska et al [ 50 ] investigated the impact of kaempferol and its glycoside derivatives isolated from Lens culinaris Medik in HL-60 cells (human acute promyelocytic leukemia) and PBMCs (peripheral blood mononuclear cells) treated with etoposide.…”

Section: Resultsmentioning

confidence: 99%

Cellular Antioxidant, Anti-Inflammatory, and Antiproliferative Activities from the Flowers, Leaves and Fruits of Gallesia integrifolia Spreng Harms

et al. 2023

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Gallesia integrifolia, a notable species in the Atlantic Forest, has been traditionally employed in folk medicine for treating rheumatism, asthma, and worms. This study investigated the cellular antioxidant, antiproliferative, and anti-inflammatory activities of the essential oils (EOs) and crude extracts (CEs) from G. integrifolia flowers, fruits, and leaves. The chemical identification of EOs was performed by GC–MS and CEs by UHPLC–MS. Cellular antioxidant and anti-inflammatory activities were assessed through mouse macrophage cell culture. In addition, the antiproliferative potential was evaluated in gastric, colorectal, breast, and lung tumor cell lines and non-tumor VERO cells. EOs predominantly contained organosulfur compounds in flowers (96.29%), fruits (94.94%), and leaves (90.72%). We found the main compound is 2,2′-Disulfanediyldiethanethiol in the EOs of flowers (47.00%), leaves (41.82%), and fruits (44.39%). Phenolic compounds were identified in CEs. The EOs and CEs demonstrated potential against the tumor cell lines tested (GI50 between 51 and 230 µg/mL). The selectivity index values were greater than 1.0 (1.01 to 3.37), suggesting a relative safety profile. Moreover, the anti-inflammatory activity IC50 ranged from 36.00 to 268 µg/mL, and the cellular oxidation inhibition ranged from 69% to 82%. The results suggest that oils and extracts derived from G. integrifolia have potential for use in various industrial sectors.

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Section: Resultsmentioning

confidence: 99%

Cellular Antioxidant, Anti-Inflammatory, and Antiproliferative Activities from the Flowers, Leaves and Fruits of Gallesia integrifolia Spreng Harms

et al. 2023

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“…Some of these compounds have been extensively studied in various articles and have been the subject of several review articles. Notable examples include Verbascoside [87,88], Echinacoside [89,90], Chlorogenic acid [91], Hydroxycinnamic acid [92], Luteolin [93,94], Apigenin [95], and Kaempferol [96]. Therefore, other detected constituents such as Medioresinol (1), Martynoside (2), Antirrhinoside (3), Isoverbascoside (4), and Apigenin-7-O-glucoside (5) (Figure 5) were discussed for their biological activities here.…”

Section: Pharmacological Activities Of Non-volatile Constituents Of R...mentioning

confidence: 99%

Phytochemical Profiling and Pharmacological Activities of Rydingia Michauxii: A Review

Tahmasebi¹,

Jamali²,

Atabaki³

et al. 2023

Preprint

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Bioactive plant compounds, also known as phytochemicals, are essential for plant resistance, growth, and development. These chemicals often possess therapeutic properties that have been used in traditional medicine for centuries as herbal remedies for a variety of diseases. As a member of the Lamiaceae family, Rydingia (Syn: Otostegia) is found in Asia and northeastern Africa. R. michauxii, is a unique shrub that grows in the Southern region of Iran, Fars province. Rydingia species have been used as traditional herbal medicine in Iran for many years. It seems that R. michauxii offers great potential for in-depth research on its diverse biological properties, especially its antioxidant and lipid-lowering effects. Nevertheless, no clinical investigation has been carried out on the phytochemical characteristics of this plant to date. Therefore, this study aims to contribute to the scientific knowledge on the pharmacological properties of R. michauxii and its phytochemical compounds and encourage researchers to evaluate its biological properties in animal models. In this study, all available scientific literature was compiled and all phytochemical and pharmacological properties of the R. michauxii plant were investigated, including antibacterial, antifungal, antiviral, antioxidant, antimalarial, cytotoxic, and lipid-lowering effects, which may prove useful in developing novel formulations with greater therapeutic benefits in clinical applications.

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“…1,2 These chemical species can be used as dietary additives in an auxiliary manner for slowing the aging process as well as preventing several diseases in humans. 3 Hence, the scientific community is constantly seeking or developing new polyphenols with enhanced antioxidant potential. 4,5 In this sense, computational-based investigations may be used to generate relevant insights and help in optimizing the search for these promising compounds.…”

Section: Introductionmentioning

confidence: 99%

A density functional theory benchmark on antioxidant-related properties of polyphenols

Mendes,

da Mata,

Brown

et al. 2024

Phys. Chem. Chem. Phys.

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Anticancer, antioxidant, ameliorative and therapeutic properties of kaempferol

Cited by 28 publications

References 62 publications

Cellular Antioxidant, Anti-Inflammatory, and Antiproliferative Activities from the Flowers, Leaves and Fruits of Gallesia integrifolia Spreng Harms

Cellular Antioxidant, Anti-Inflammatory, and Antiproliferative Activities from the Flowers, Leaves and Fruits of Gallesia integrifolia Spreng Harms

Phytochemical Profiling and Pharmacological Activities of Rydingia Michauxii: A Review

A density functional theory benchmark on antioxidant-related properties of polyphenols

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