Anticancer Antibiotics

Saeidnia, Soodabeh

doi:10.1007/978-3-319-14027-8_4

Cited by 8 publications

(7 citation statements)

References 60 publications

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“…Anticancer antibiotics are mainly anthraquinones and peptides that determine an inhibitory effect on the proliferation and uncontrolled growth of cancer cells. The main classes of antibiotics with effect on cancer cells are anthracyclines, bleomycin, actinomycin, mitomycin, guanorycin and endiyne [ 204 ].…”

Section: Antibiotics and Cancermentioning

confidence: 99%

Antibiotics: Conventional Therapy and Natural Compounds with Antibacterial Activity—A Pharmaco-Toxicological Screening

et al. 2021

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Antibiotics are considered as a cornerstone of modern medicine and their discovery offers the resolution to the infectious diseases problem. However, the excessive use of antibiotics worldwide has generated a critical public health issue and the bacterial resistance correlated with antibiotics inefficiency is still unsolved. Finding novel therapeutic approaches to overcome bacterial resistance is imperative, and natural compounds with antibacterial effects could be considered a promising option. The role played by antibiotics in tumorigenesis and their interrelation with the microbiota are still debatable and are far from being elucidated. Thus, the present manuscript offers a global perspective on antibiotics in terms of evolution from a historical perspective with an emphasis on the main classes of antibiotics and their adverse effects. It also highlights the connection between antibiotics and microbiota, focusing on the dual role played by antibiotics in tumorigenesis. In addition, using the natural compounds with antibacterial properties as potential alternatives for the classical antibiotic therapy is discussed.

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Section: Antibiotics and Cancermentioning

confidence: 99%

Antibiotics: Conventional Therapy and Natural Compounds with Antibacterial Activity—A Pharmaco-Toxicological Screening

et al. 2021

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“…It is expensive and technically challenging to evaluate the anticancer effect for all the clones, as opposed to screening for antibiosis. By this approach, we aimed to investigate the antibacterial activity of the active clones more thoroughly, and then test for anticancer effect, due to the reason that many anticancer agents were originally discovered by having an antibacterial effect [ 6 ]. Although both 14-7E and 10-2G were originally obtained from the same ATII LCL metagenome, they resulted into differential decrease in cell viability.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, mining nature for bioactive molecules has proven valuable in investigating diverse environmental niches, and will undoubtedly shed light on new chemistries with bioactivity, specifically antibiosis and anticancer effects [ 3 – 5 ]. Interestingly, since the early forties some antibiotic compounds have been known to also possess anticancer activity [ 6 ]. This group of anticancer antibiotics includes drugs of diverse chemical structures, such as bleomycin, actinomycin D and doxorubicin [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial and anticancer activities of orphan biosynthetic gene clusters from Atlantis II Red Sea brine pool

et al. 2019

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BackgroundCancer and infectious diseases are problematic because of continuous emergence of drug resistance. One way to address this enormous global health threat is bioprospecting the unlikeliest environments, such as extreme marine niches, which have tremendous biodiversity that is barely explored. One such environment is the Red Sea brine pool, Atlantis II Deep (ATII). Here, we functionally screened a fosmid library of metagenomic DNA isolated from the ATII lower convective layer (LCL) for antibacterial and anticancer activities.ResultsSelected clones, 14-7E and 10-2G, displayed antibacterial effects on the marine strain Bacillus sp. Cc6. Moreover, whole cell lysates from 14-7E and 10-2G exhibited decreased cell viability against MCF-7 (39.1% ± 6.6, 42% ± 8.1 at 50% v/v) and U2OS cells (35.7% ± 1.9, 79.9% ± 5.9 at 50% v/v), respectively. By sequencing the insert DNA from 14-7E and 10-2G, we identified two putative orphan biosynthetic gene clusters. Both clusters harbored putative ATP-binding cassette (ABC) transporter permeases and S-adenosylmethionine-related genes. Interestingly, the biosynthetic gene cluster identified on 14-7E is of archaeal origin and harbors a putative transcription factor. Several identified genes may be responsible for the observed antibacterial and anticancer activities. The 14-7E biosynthetic gene cluster may be encoding enzymes producing a specialized metabolite (effect of detected genes involved in C–C bond formation and glycosylation). The bioactivity may also be due to predicted subtilases encoded by this cluster. The 10-2G cluster harbored putative glycosyltransferase and non-ribosomal peptide synthase genes; thus the observed activity of this clone could be caused by a bioactive peptide.ConclusionsThe ATII LCL prokaryotic metagenome hosts putative orphan biosynthetic gene clusters that confer antibiotic and anticancer effects. Further biochemical studies should characterize the detected bioactive components, and the potential use of 14-7E metabolite for antibiosis and 10-2G metabolite as a selective anti-breast cancer drug.Electronic supplementary materialThe online version of this article (10.1186/s12934-019-1103-3) contains supplementary material, which is available to authorized users.

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“…Some of them, such as aglycon, are usually inactive, but amongst hundreds of anthracyclines molecular analogues with antitumoral and antimicrobial activity, FDA approved a small number for clinical administration: actinomycin D (dactinomycin), daunorubicin, doxorubicin, epirubicin, idarubicin, mitomycin, mitoxantrone, plicamycin, valrubicin, enediyne, guanorycin, etc. (Saeidnia, 2015). Some of these are active, especially after chemical change, irrespective of cell cycle stage, even in G0, inhibiting proliferation, acting as pro-apoptosis and anti-epithelial-mesenchymal transition factors, thus inhibiting metastasis (Zhou J, 2013).…”

Section: Anthracyclinesmentioning

confidence: 99%

Antitumor antibiotics: representatives, mechanisms of action and side effects

MIHAESCU,

CONSTANTIN,

ANDRONIC

et al. 2022

RBL

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Bacteria and fungi synthesize various compounds necessary for their own metabolism, as well as compounds that kill other microbial strains and species from the environment in which they grow, to ensure their access to sufficient supplies. Since the discovery of their antitumor effect, three main classes of antibiotics are used in cancer therapy: anthracyclines (secondary metabolites, mainly produced by members of Streptomyces group, or semisynthetic derivatives containing the 7,8,9,10-tetrahidrotetracen-5.12 quinone structure), peptide antibiotics and quinolones. In this minireview, we will present the mechanisms of action, main representatives and side effects of these anti-cancer agents.

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Anticancer Antibiotics

Cited by 8 publications

References 60 publications

Antibiotics: Conventional Therapy and Natural Compounds with Antibacterial Activity—A Pharmaco-Toxicological Screening

Antibiotics: Conventional Therapy and Natural Compounds with Antibacterial Activity—A Pharmaco-Toxicological Screening

Antibacterial and anticancer activities of orphan biosynthetic gene clusters from Atlantis II Red Sea brine pool

Antitumor antibiotics: representatives, mechanisms of action and side effects

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