Anticancer, anti-proliferative activity of Avicennia marina plant extracts

Albinhassan, Tahani H; Saleh, Kamel A.; Barhoumi, Zouhaier; Alshehri, Mohammed Ali; Al-ghazzawi, Adel M.

doi:10.4103/jcrt.jcrt_659_19

Cited by 8 publications

(4 citation statements)

References 41 publications

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“…Previous studies showed that the mangrove extract decreased cell proliferation at different concentrations [34,38,39]. Previous studies on the anticancer effects of mangrove extracts could be different due to the type of the cells, type of the extract, and different concentrations of the extract [38,40]. By the way, the current study showed that the ethanol extract of A. marina leaves induced its anti-proliferative effects by cell cycle arrest in MCF-7 breast cancer cell lines.…”

Section: Figs 5g-5i)mentioning

confidence: 57%

Phytochemical Analysis, Computational Modeling and Experimental Evaluations of Avicennia Marina Anti-cancer Activity on Breast, Ovarian and Cervical Cancer Cell Lines Running Title: Anti-cancer Activity of Avicennia Marina

Afshar¹,

Khoradmehr²,

Zare³

et al. 2021

Preprint

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Background: Avicennia marina, the gray mangrove, is an herbal source of bioactive anti-cancer compounds.Purpose: The present study aimed to evaluate phytochemical compositions of ethanol and ethyl acetate extracts of A. marina leaves and experimental study and computational modeling of their anti-cancer activity on breast, ovarian and cervical cancer cell lines.Study design: Phytochemical analysis, computational modeling and experimental in vitro evaluationMethods: Phytochemical analysis and GC-MS analysis were used to detect phenolic and flavonoid contents in ethanol and ethyl acetate extracts of A. marina leaves. Cell proliferation, viability, cycle and western blot assays of the extracts were performed on MCF-7, OVCAR3, and HeLa. Computational modeling done to detect effective compounds.Results: The extracts of A. marina leaves had high phenolic and flavonoid contents. In GC-MS analysis of the extracts, anti-cancer and anti-proliferative compounds were detected. Moreover, after treatment of MCF-7, OVCAR3, and HeLa, separately, the MTT assay, cell proliferation assay, and cell viability assays showed anti-proliferative activity, decreasing of cell population and decreasing cell viability, respectively. In addition, the cell cycle analysis showed that the S phase of the cell cycle increased in MCF-7. Moreover, the western blot analysis showed that the pro-apoptotic cell effectors such as Bax and caspase-1, -3, and -7 increased. Computational results of affinity of ligands detected by GC-MS compounds and stimulated apoptosis effectors detected by western blot showed five molecules in A. marina leaves playing role in OVCAR3 and HeLa apoptosis.Conclusion: The extracts of A. marina leaves have anti-cancer effects on breast, ovarian and cervical cancer cells via cell cycle arrest or apoptotic mechanisms.

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Section: Figs 5g-5i)mentioning

confidence: 57%

Phytochemical Analysis, Computational Modeling and Experimental Evaluations of Avicennia Marina Anti-cancer Activity on Breast, Ovarian and Cervical Cancer Cell Lines Running Title: Anti-cancer Activity of Avicennia Marina

Afshar¹,

Khoradmehr²,

Zare³

et al. 2021

Preprint

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“…The anti-cacner effect was studied for the Avicenna marina methnolic extract, which was found to have a notable cytotoxic effect on the hepatocellular carcinoma cancer cell line (HepG2), indicating an anticancer activity [33] . Besides, another study has also revealed that hexane extract of Avicenna marina presented a high cell inhibitory effect on hepatocellular and breast cancer cell lines [34] . Decisively, the in-vivo study on the extracts of Avicenna marina and Rhizophora Mucronata in combination or alone has explored the antioxidant and antidiabetic effects on streptozotocin induced diabetic rats [35] .…”

Section: Acanthaceae Familymentioning

confidence: 98%

Medicinal properties of Qatari wetland plants: A review

Al-Jaber,

Abu-Rub,

Kunhipurayil

et al. 2024

Int. J. Herb. Med.

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For over 60,000 years, human dependence on herbal remedies has been a cornerstone of traditional medicine. However, recent times have witnessed escalating concerns about the sustainability of these practices, especially regarding their impact on local culture, biodiversity, and environmental integrity. This issue is particularly pronounced in Qatar, where wetlands play a vital role yet remain insufficiently studied. A comprehensive literature review aimed at identifying wetland plant species traditionally used by the people of Qatar revealed 17 such species from six families, predominantly from the Amaranthaceae family. These plants, thriving in diverse habitats, exhibit promising therapeutic properties, including anti-cancer, anti-diabetic, anti-inflammatory, and anti-microbial activities. Noteworthy is that over 50% of the examined plants possess both antioxidant and anti-inflammatory attributes. Despite their potential, less than 30% of these plants have been explored for their anti-cancer potential. Conservation efforts are imperative to safeguard these unique wetland ecosystems, and further research is essential to validate and unlock the full therapeutic potential of these plants for the development of potent, plant-based drugs.

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“…A considerable number of reports are available in which halophytic plant extracts and their fractions have been screened for cytotoxic and antiproliferative effects [ 150 , 151 , 152 , 153 , 154 ]. Most of these reports evaluated the anticancer activity of plant extracts and fractions that were identified by liquid chromatography–mass spectrometry (LC–MS) and gas chromatography–mass spectrometry (GC–MS) [ 153 , 154 , 155 ] for the presence of the chemical constituents.…”

Section: Evaluating Anti-cancer Activities Of Halophytic Plants Extractsmentioning

confidence: 99%

Salt-Tolerant Plants, Halophytes, as Renewable Natural Resources for Cancer Prevention and Treatment: Roles of Phenolics and Flavonoids in Immunomodulation and Suppression of Oxidative Stress towards Cancer Management

Mohammed

Emwas

Khan

2023

IJMS

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Halophytes and xerophytes, plants with adequate tolerance to high salinity with strong ability to survive in drought ecosystem, have been recognized for their nutritional and medicinal values owing to their comparatively higher productions of secondary metabolites, primarily the phenolics, and the flavonoids, as compared to the normal vegetation in other climatic regions. Given the consistent increases in desertification around the world, which are associated with increasing salinity, high temperature, and water scarcity, the survival of halophytes due to their secondary metabolic contents has prioritized these plant species, which have now become increasingly important for environmental protection, land reclamation, and food and animal-feed security, with their primary utility in traditional societies as sources of drugs. On the medicinal herbs front, because the fight against cancer is still ongoing, there is an urgent need for development of more efficient, safe, and novel chemotherapeutic agents, than those currently available. The current review describes these plants and their secondary-metabolite-based chemical products as promising candidates for developing newer cancer therapeutics. It further discusses the prophylactic roles of these plants, and their constituents in prevention and management of cancers, through an exploration of their phytochemical and pharmacological properties, with a view on immunomodulation. The important roles of various phenolics and structurally diverse flavonoids as major constituents of the halophytes in suppressing oxidative stress, immunomodulation, and anti-cancer effects are the subject matter of this review and these aspects are outlined in details.

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Anticancer, anti-proliferative activity of Avicennia marina plant extracts

Cited by 8 publications

References 41 publications

Phytochemical Analysis, Computational Modeling and Experimental Evaluations of Avicennia Marina Anti-cancer Activity on Breast, Ovarian and Cervical Cancer Cell Lines Running Title: Anti-cancer Activity of Avicennia Marina

Phytochemical Analysis, Computational Modeling and Experimental Evaluations of Avicennia Marina Anti-cancer Activity on Breast, Ovarian and Cervical Cancer Cell Lines Running Title: Anti-cancer Activity of Avicennia Marina

Medicinal properties of Qatari wetland plants: A review

Salt-Tolerant Plants, Halophytes, as Renewable Natural Resources for Cancer Prevention and Treatment: Roles of Phenolics and Flavonoids in Immunomodulation and Suppression of Oxidative Stress towards Cancer Management

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