Anticancer and therapeutic potential of Delonix regia extract and silver nanoparticles (AgNPs) against pancreatic (Panc-1) and breast (MCF-7) cancer cell

Rajiri, Mobina Shameli; Aminsalehi, Mahsa; Shahbandeh, Mahsa; Maleki, Ali; Jonoubi, Parissa; Rad, Abdolkarim Chehregani

doi:10.1007/s13530-020-00067-1

Cited by 14 publications

(11 citation statements)

References 31 publications

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“…Among the different concentrations employed to treat cancer cells, the greatest concentration showing a 64.45% inhibition was 300 μg/ml and the lowest (11.52%) inhibition was found in 18.75 μg/ml with an IC 50 value of 97.29 μg/ml. Our results showed that the inhibitory value clearly demonstrated the potential dependency of untreated MCF‐7 cells on monolayer cells with membranes and AgNPs on treated cancer cells show rounding shape. 62 Recent studies found that Parrotiopsis jacquemontiana AgNPs IC 50 value was 91.90 μg/ml.…”

Section: Resultssupporting

confidence: 51%

“…Our results showed that the inhibitory value clearly demonstrated the potential dependency of untreated MCF-7 cells on monolayer cells with membranes and AgNPs on treated cancer cells show rounding shape . 62 Recent studies found that Parrotiopsis jacquemontiana AgNPs IC 50 value was 91.90 μg/ml . 63 Another set of comparable data was reported for Scindapsus officinalis, which had an IC 50 of 97.72 μg/ml .64…”

Section: Antiproliferative Effect Of Mcf-7 Cellsmentioning

confidence: 99%

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Preparation and characterization of biogenic silver nanoparticles using Strobilanthes cordifolia (Vahl) J.R.I. Wood leaves and its biological applications

Kirubakaran

Selvam

Prakash

et al. 2022

Biotech and App Biochem

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In the present study, aqueous leaf extract of Strobilanthes cordifolia J.R.I.Wood was combined with silver nitrate to synthesis silver nanoparticles (AgNPs). The AgNPs were characterized using visible spectroscopy (UV), X-ray diffraction (XRD), Fourier transform infrared spectrophotometer (FTIR), scanning electron microscope (SEM), energy dispersive X-ray (EDaX), particle size analysis, and transmission electron microscope (TEM). The UV spectrum absorption peak occurred at 438 nm. The FTIR analysis of the AgNPs indicated the presence of functional groups such as aldehyde, alkenes, and carboxylic acids. The crystalline structure of AgNPs was confirmed by XRD. The AgNPs have a spherical shape according to SEM. The AgNPs components composition was confirmed by EDaX. The particle size distribution of AgNPs is monodispersion in the range at 42.54 nm. TEM demonstrated the AgNPs size to be between 11.35 and 34.90 nm. The AgNPs exhibited good antibacterial property against Escherichia coli and Staphylococcus aureus. The antioxidant activity of the AgNPs was represented by increased DPPH, ABTS, and H 2 O 2 activities.The antidiabetic activity of the AgNPs was indicated by the inhibition of α-amylase and α-glycosidase and antiinflammatory highest albumin denaturation and HRBC membrane stabilization properties. Further, the AgNPs also significantly inhibited the MCF-7 cell lines. These results clearly suggest that the synthesized AgNPs using S. cordifolia leaves could have several potential biomedical applications.

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Section: Resultssupporting

confidence: 51%

Section: Antiproliferative Effect Of Mcf-7 Cellsmentioning

confidence: 99%

Preparation and characterization of biogenic silver nanoparticles using Strobilanthes cordifolia (Vahl) J.R.I. Wood leaves and its biological applications

Kirubakaran

Selvam

Prakash

et al. 2022

Biotech and App Biochem

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“…Similarly, Balkrishna et al [ 57 ] reported that the lowest concentration of AgNO 3 can also cause damage to normal cells, whereas AgNPs from Putranjiva roxburghii seed extract exhibited no toxicity at the same concentration. Rajiri et al reported that Delonix regia extract and AgNPs both had few effects on normal cells and did not affect the cell proliferation of normal cells; whereas, in the case of MCF-7 breast cancer cells, the combination of D. regia extract and AgNPs exhibited a significant inhibition of cancer cells [ 58 ]. Several studies have been conducted that evaluated cytotoxicity without the use of interference controls.…”

Section: Discussionmentioning

confidence: 99%

Myco-Nanofabrication of Silver Nanoparticles by Penicillium brasilianum NP5 and Their Antimicrobial, Photoprotective and Anticancer Effect on MDA-MB-231 Breast Cancer Cell Line

et al. 2023

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Currently, the exploration of fungal organisms for novel metabolite production and its pharmacological applications is much appreciated in the biomedical field. In the present study, the fungal strains were isolated from soil of unexplored Yellapura regions. The potent isolate NP5 was selected based on preliminary screening and identified as Penicillium brasilianum NP5 through morphological, microscopic, and molecular characterizations. Synthesis of silver nanoparticles from P. brasilianum was confirmed by the color change of the reaction mixture and UV-visible surface plasmon resonance (SPR) spectra of 420 nm. Fourier transform infrared (FTIR) analysis revealed the functional groups involved in synthesis. Atomic force microscopy (AFM) and transmission electron microscope (TEM) analysis showed aggregation of the NPs, with sizes ranged from 10 to 60 nm, an average particle size of 25.32 nm, and a polydispersity index (PDI) of 0.40. The crystalline nature and silver as the major element in NP5-AgNPs was confirmed by X-ray diffraction (XRD) and energy dispersive X-ray (EDX) analysis. The negative value −15.3 mV in Zeta potential exhibited good stability, and thermostability was recorded by thermogravimetric analysis (TGA). NP5-AgNPs showed good antimicrobial activity on selected human pathogens in a concentration-dependent manner. The MTT assay showed concentration-dependent anticancer activity with an IC50 of 41.93 µg/mL on the MDA-MB-231 cell line. Further, apoptotic study was carried out by flow cytometry to observe the rate of apoptosis. The calculated sun protection factor (SPF) value confirms good photoprotection capacity. From the results obtained, NP5-AgNPs can be used in the pharmaceutical field after successful in vitro clinical studies.

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“…Comparing the vitality of pancreatic cancer cells treated with D. regia extract containing AgNPs to that of control cells, the results demonstrated a significant decrease. MTT analysis revealed that the IC 50 of D. regia extract on pancreatic cell lines was 0.5 mg/mL, while the maximum inhibition of cell lines was observed at 1.5 mg/L concentration [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

Characterization of Delonix regia Flowers’ Pigment and Polysaccharides: Evaluating Their Antibacterial, Anticancer, and Antioxidant Activities and Their Application as a Natural Colorant and Sweetener in Beverages

et al. 2023

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In the present study, an attempt was made to investigate the in vitro antioxidant, anticancer, and antibacterial activities of Delonix regia, then in vivo evaluate its safety as a natural colorant and sweetener in beverages compared to synthetic colorant and sweetener in rats, then serve the beverages for sensory evaluation. Delonix regia flowers had high protein, polysaccharide, Ca, Na, Mg, K, and Fe contents. The Delonix regia pigment extract (DRPE) polysaccharides were separated and purified by gel permeation chromatography on Sephacryl S-200, characterized by rich polysaccharides (13.6 g/L). The HPLC sugar profile detected the monosaccharides in the extracted polysaccharides, composed of mannose, galactose, glucose, arabinose, and gluconic acid, and the structure of saccharides was confirmed by FTIR, which showed three active groups: carbonyl, hydrocarbon, and hydroxyl. On the other hand, the red pigment constituents of DRPE were detected by HPLC; the main compounds were delphinidin and cyanidin at 15 µg/mL. The DRPE contained a considerable amount (26.33 mg/g) of anthocyanins, phenolic compounds (64.7 mg/g), and flavonoids (10.30 mg/g), thus influencing the antioxidant activity of the DRPE, which scavenged 92% of DPPH free radicals. Additionally, it inhibited the population of pathogenic bacteria, including Staphylococcus aureus, Listeria monocyogenes, Salmonella typhimurum, and Pseudomonas aeruginosa, in the range of 30–90 μg/mL, in addition to inhibiting 85% of pancreatic cancer cell lines. On the in vivo level, the rats that were delivered a diet containing DRPE showed regular liver markers (AST, ALP, and ALT); kidney markers (urea and creatinine); high TP, TA, and GSH; and low MDA, while rats treated with synthetic dye and aspartame showed higher liver and kidney markers; lowered TP, TA, and GSH; and high MDA. After proving the safety of DRPE, it can be safely added to strawberry beverages. Significant sensorial traits, enhanced red color, and taste characterize the strawberry beverages supplemented with DRPE. The lightness and redness of strawberries were enhanced, and the color change ΔE values in DRPE-supplemented beverages ranged from 1.1 to 1.35 compared to 1.69 in controls, indicating the preservative role of DRPE on color. So, including DRPE in food formulation as a natural colorant and sweetener is recommended for preserving health and the environment.

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Anticancer and therapeutic potential of Delonix regia extract and silver nanoparticles (AgNPs) against pancreatic (Panc-1) and breast (MCF-7) cancer cell

Cited by 14 publications

References 31 publications

Preparation and characterization of biogenic silver nanoparticles using Strobilanthes cordifolia (Vahl) J.R.I. Wood leaves and its biological applications

Preparation and characterization of biogenic silver nanoparticles using Strobilanthes cordifolia (Vahl) J.R.I. Wood leaves and its biological applications

Myco-Nanofabrication of Silver Nanoparticles by Penicillium brasilianum NP5 and Their Antimicrobial, Photoprotective and Anticancer Effect on MDA-MB-231 Breast Cancer Cell Line

Characterization of Delonix regia Flowers’ Pigment and Polysaccharides: Evaluating Their Antibacterial, Anticancer, and Antioxidant Activities and Their Application as a Natural Colorant and Sweetener in Beverages

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