Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects

Fedorov, Sergey N.; Ermakova, Svetlana P.; Zvyagintseva, T. N.; Stonik, Valentin A.

doi:10.3390/md11124876

Cited by 156 publications

(78 citation statements)

References 154 publications

(171 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Jayamadhuri and Krishna (2013) isolated actinomycete strains from a tidal zone, and reported that actinomycete extracts had cytotoxic effects on the growth of breast cancer cell lines [20]. Fedorov conducted a study on marine actinomycetes in 2013 and reported that actinomycetes had a great potential in the treatment of cancer consistent with the result of the present study [21]. Ravikumar et al, (2012) reported that the anti-cancer property of cell-free extracts from actinomycete isolates might be due to the presence of the active secondary metabolites such as alkaloids and quinines [14].…”

Section: Discussionsupporting

confidence: 74%

Molecular Identification, Isolation and Evaluation of Persian Gulf Actinomycetes as Candidates of Cytotoxic Metabolites Against Breast Cancer

Bahri

Moazamian

Azarpira

2017

mcij

View full text Add to dashboard Cite

Introduction: Marine actinomycetes have a great potential to produce unique bioactive compounds due to their special adaptation in the harsh ocean environment. The current study aimed to isolate anti-cancer compounds producing actinomycetes from sediments of Harra forests of the Persian Gulf and investigate their potential as anti-breast cancer metabolites. Methods: In the current study, 40 sediment samples of Harra forests of the Persian Gulf were collected. Samples were diluted and cultured in a starch casein agar selective medium. The strains were isolated and purified, using morphological and microscopic methods. Forty strains were cultured in a starch casein broth and the metabolites were extracted using ethyl acetate. The produced metabolites were extracted from active strains and their cytocidal activities were evaluated against the breast cancer cell line. Finally, effective-metabolites-producing bacteria were identified using the molecular method. Results: Of the sediments, 186 strains were isolated and identified. Results showed that the isolates had cytocidal activities against the breast cancer cell line. The results also revealed that the 2HP and 4HP strains showed more anti-cancer activities than the others. Results of this study showed that sediments of Harra forests of the Persian Gulf were rich in active actinomycetes, which can be used in the production of new anticancer compounds. Conclusions:The obtained results give evidence that it is essential to scrutinize these marine microorganisms, which have a great potential to be used in the pharmaceutical fields, in search for new drugs.

show abstract

Section: Discussionsupporting

confidence: 74%

Molecular Identification, Isolation and Evaluation of Persian Gulf Actinomycetes as Candidates of Cytotoxic Metabolites Against Breast Cancer

Bahri

Moazamian

Azarpira

2017

mcij

View full text Add to dashboard Cite

show abstract

“…Additional chemical modifications could be explored to further improve the activity of BGF. Developing saccharide mimetics for in vivo applications is possible and might be explored in the future as well for the Lewis Y analogue BGF or similar compounds [18]. A particularly interesting aspect is that Lewis Y inhibitors will not serve as universal angiogenesis inhibitors but rather show selectivity for pathophysiological situations with TNF-alpha over expression which is known e.g.…”

Section: Discussionmentioning

confidence: 99%

A Furan-Based Lewis-Y-(CD174)-Saccharide Mimetic Inhibits Endothelial Functions and In Vitro Angiogenesis

Sauer¹,

Meißner²,

Michel³

2015

Adv Clin Exp Med

View full text Add to dashboard Cite

Background. Angiogenesis is a fundamental process underlying cancer progression and autoimmune disease. Lewis Y is known as a regulated glycan-structure supporting human endothelial function and angiogenesis. Objectives. We hypothesize that Lewis Y based analogues interfere with Lewis Y mediated endothelial functions and angiogenesis. We therefore evaluated the ability of 3, 4-bis [(b-D-galactopyranosyl)osy]-methyl-furan (BGF) a furan-based Lewis-Y saccharide mimetic to inhibit human endothelial adhesion, migration and in vitro angiogenesis. Material and Methods. The ability of BGF and additional furan-based saccharide-mimetics was investigated to inhibit adhesion and migration of human bone marrow endothelial cells (HBMEC). Influence of BGF was tested on a multicelluar in vitro -angiogenesis assay in the presence of VEGF. Results. BGF significantly inhibited HBMEC adhesion and migration stimulated by TNF-alpha by up to 70%. The anti-adhesive effect of BGF was particularly evident when HBMEC adhesion and migration was tested on collagen as extracellular matrix with weaker effect when laminin and fibronectin were used as an extracellular matrix. BGF was ineffective when HBMEC were stimulated with VEGF. The inhibition of endothelial function translated into a significant inhibitory effect of BGF in the multicellular in vitro angiogenesis-assay. BGF reduced the angiogenesis index compared to the positive controls by 32%. Conclusions. We identified the ability of the furan-based Lewis Y saccharide mimetic BGF as a specific modulator of TNF-alpha activated endothelial function and in vitro angiogenesis. BGF and other related glycan analogues should further be explored for their ability to down modulate endothelial activation in TNF-alpha driven pathophysiologic conditions in autoimmune disease and cancer indications (Adv Clin Exp Med 2015, 24, 5, 759-768).

show abstract

“…Eventually, microalgae are almost an untapped resource of natural antioxidants due to their enormous biodiversity, much more diverse than higher plants. They contain various biologically active compounds that are been used as source of food, feed and medicine [7] . Microalgae are proposed as an alternative molecular pharming system.…”

mentioning

confidence: 99%

“…Antioxidants are presumed to have several positive health effects that include prevention of cardiovascular disorders, ageing related diseases such as Alzheimer and certain types of cancer [10] . Microalgae in this regard are exceptionally rich source of pharmacologically active metabolites with antineoplastic, antitumor, antibacterial, antifungal and antiviral properties [7] .…”

mentioning

confidence: 99%

Chlorella vulgaris and Chlamydomonas reinhardtii: Effective Antioxidant, Antibacterial and Anticancer Mediators

Jayshree¹,

Jayashree²,

Thangaraju³

2016

IJPS

View full text Add to dashboard Cite

Jayshree, et al.: Microalgae: Effective Health MediatorsAlgae are rich sources of structurally novel and biologically active metabolites. Primary and secondary metabolites produced by these organisms have drawn interest of the pharmaceutical industries. In this regard we have put forth an investigation to evaluate phenolic and flavonoid content in methanol extract of fresh algal biomass followed by antioxidant, antimicrobial and anticancer activities. Determination of total phenol and flavonoid content was followed by the 2,2-diphenyl-1-picrylhydrazyl radicals scavenging, phosphomolybdate and reducing power assay for evaluating antioxidant potency. Agar well diffusion method for antibacterial activity and trypan blue test along with MTT assay was done for anticancer activity. Among two microalgae, Chlorella vulgaris had efficiently high amount of total phenol and flavonoid content. Chlorella vulgaris is a single-celled eukaryotic green micro algae, known to be first form of a plant with a well-defined nucleus emerged over 2 billion years ago [1] . Chlorella contains the highest amount of chlorophyll of any known plant. Chlamydomonas reinhardtii, another unicellular algae though not much explored as nutrient supplement; it is well known model organism with its three genomes (nuclear, plastidial and mitochondrial) completely sequenced [2] . It finds its application mostly in molecular biology especially in studies involving flagellar motility, chloroplast dynamics, biogenesis and genetics [3] . C. vulgaris is well determined nutrientdense superfood containing 60% protein, 18 amino acids, 20 vitamins and minerals like iron, calcium, potassium, magnesium and phosphorous [4] . One of its unique properties is a phytonutrient called Chlorella Growth Factor [1] . These two microalgae are known for high volume production of β-carotene.Besides being food supplements microalgae, Chlorella sp., Chlamydomonas sp. have been proved to have antibacterial activity in vitro against both Gram positive and Gram negative bacteria [5] . The production of extracellular antibiotic metabolites by marine algae has been well studied in recent years. They are also been reported that a wide range of antifungal activities were obtained from extracts of green microalgae [6] . Eventually, microalgae are almost an untapped resource of natural antioxidants due to their enormous biodiversity, much more diverse than higher plants. They contain various biologically active compounds that are been used as source of food, feed and medicine [7] . Microalgae are

show abstract

Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects

Cited by 156 publications

References 154 publications

Molecular Identification, Isolation and Evaluation of Persian Gulf Actinomycetes as Candidates of Cytotoxic Metabolites Against Breast Cancer

Molecular Identification, Isolation and Evaluation of Persian Gulf Actinomycetes as Candidates of Cytotoxic Metabolites Against Breast Cancer

A Furan-Based Lewis-Y-(CD174)-Saccharide Mimetic Inhibits Endothelial Functions and In Vitro Angiogenesis

Chlorella vulgaris and Chlamydomonas reinhardtii: Effective Antioxidant, Antibacterial and Anticancer Mediators

Contact Info

Product

Resources

About