Anticancer and antimicrobial evaluation of newly synthesized steroidal 5,6 fused benzothiazines

QSAR Studies and Design of Some Tetracyclic 1,4-Benzothiazines as Antimicrobial Agents

“…The value of correlation coefficient is more than 0.85 for all the models. Also the values of R 2 adj are high and the difference between R 2 − R 2 adj is very less for all models confirming that R 2 adj is very near to coefficient of determination of the developed models. The value of standard error (s) is very small for all these QSAR models.…”

“…In this perspective, particularly 1,4-benzothiazines indubitably correspond to a class of bioactive heterocyclic molecules as compounds bearing this structural moiety attain admirable biological activities and exploitation as key structural motif for the preparation of assorted natural products of pharmaceutical importance [1]. These scaffolds have been found to elicit their role, as antimicrobial [2], antitumoral [3], antidepressant [4], anti-inflammatory [5], antiarrhythmic [6], antidiabetic [7], antihypertensive [8], antirheumatic [9], antimalarial [10], anti-HIV [11], antitubercular [12] agents, antipsychotics [13], antioxidants [14], etc. Owing to the diverse applications of 1,4-benzothiazine derivatives, various synthetic routes for their preparation have been developed [15][16][17][18].…”

Design, Synthesis and Bio-evaluation of New Phenothiazine Derivatives of Sulfonamide Dyes as Anticancer Agents

“…Cell survival has been calculated using the formula: Cell Viability (%) = [(absorbance of treated cells -absorbance of culture medium)/(absorbance of untreated cellsabsorbance of culture medium)] x100. [31] The percentage viability of cells was measured by MTT assay. Table 2 shows the minimum viability percentage of the maximum Drug concentrations in µM.…”

Thiazole as an Indispensable Scaffold in Anti‐Leukemic Agents: A Semicentennial Review

“…In the biological study of this series, the IC 50 value for compound 124 against leukemia cell line HL-60 was 14.71 � 0.3 μM. [38] Another series of novel thiazole derivatives came into the picture of leukemia in 2015, invention of 6-phenylimidazo Compound 127 was the subject of extensive in vitro research on its anti-AML effectiveness and mechanism of action investigations. [39] A new type of thiazole derivatives were discovered in 2016.…”