Anticancer and anticholesterol attributes of sea cucumbers: An opinion in terms of functional food applications

Salindeho, Netty; Mayulu, Nelly; Gunawan, William Ben; Handoko, Matthew Nathaniel; Samtiya, Mrinal; Muliadi, Rendy Dijaya

doi:10.3389/fnut.2022.986986

Cited by 4 publications

(1 citation statement)

References 39 publications

(47 reference statements)

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“…Despite great efforts of research, effective cancer treatment is still lacking, implying the need for other sources of the cancer-treating agent such as natural sources. Natural sources – especially underutilized marine products – have promising potential as functional food or nutraceutical with anticancer properties ( 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

Green seaweeds fatty acids and heterocyclic derivatives against cancer: Opinion on future nutraceutical application

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Green seaweeds fatty acids and heterocyclic derivatives against cancer: Opinion on future nutraceutical application

et al. 2023

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Chromosome-level genome assembly of the sea cucumber Apostichopus japonicus

Sun

Jiang

et al. 2023

Sci Data

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Sea cucumber is a morphologically diverse and ecologically important clade of echinoderms. The sea cucumber Apostichopus japonicus is the most economically valuable species of sea cucumber. The initial assembly of the A. japonicus genome was released in 2017. However, this genome assembly is fragmented and lacks relative position information of genes on chromosomes. In this study, we produced a high-quality chromosome-level genome of A. japonicus using Pacbio HiFi long-reads and Hi-C sequencing data. The assembled A. japonicus genome spanned 671.60 Mb with a contig N50 size of 17.20 Mb and scaffold N50 size of 29.65 Mb. A total of 99.9% of the assembly was anchored to 23 chromosomes. In total, 19,828 genes were annotated, and 97.2% of BUSCO genes were fully represented. This high-quality genome of A. japonicus will not only aid in the development of sustainable aquaculture practices, but also lay a foundation for a deeper understanding of their genetic makeup, evolutionary history, and ecological adaptation.

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Network Pharmacology Analysis Reveals Bioactive Compounds and Potential Targets of Sea cucumber for Cervical Cancer Therapy

Ujianti,

Semara Lakshmi,

Nurusshofa

et al. 2023

F1000Res

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Cervical cancer is a leading cause of death among women in many countries, and finding effective anticancer treatments for this type of cancer is challenging due to high rates of HPV infection and low vaccination rates among women of childbearing age. Studies have shown that protein oncogenes produced by HPV stimulate cell growth, promoting tumor development and treatment resistance. It explores the potential therapeutic mechanisms of Scitophus hermanii in treating cervical cancer using network pharmacology, identifying PTGS2, EGFR, and NFE2L2 as targets. Bioactive compounds in sea cucumbers, such as Gangliosides, Stichoposide and variegatuside have the potential to prevent cancer cell proliferation by inhibiting the epidermal growth factor receptor expression. The review suggests that targeting pathways could be a promising strategy for the treatment of cervical cancer. SwissADME also predicted the drug-like properties of the active chemicals in sea cucumbers. This discussion sheds new light on the potential use of marine natural products for the treatment of various types of cervical cancers.

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Anticancer and anticholesterol attributes of sea cucumbers: An opinion in terms of functional food applications

Cited by 4 publications

References 39 publications

Green seaweeds fatty acids and heterocyclic derivatives against cancer: Opinion on future nutraceutical application

Green seaweeds fatty acids and heterocyclic derivatives against cancer: Opinion on future nutraceutical application

Chromosome-level genome assembly of the sea cucumber Apostichopus japonicus

Network Pharmacology Analysis Reveals Bioactive Compounds and Potential Targets of Sea cucumber for Cervical Cancer Therapy

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