Anticancer and anti-Inflammatory Activities of Garcinol and Its Analogs

Basha, N. Jeelan

doi:10.1080/10406638.2023.2270116

Cited by 1 publication

(1 citation statement)

References 92 publications

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“…Garcinol, abundant in G. indica fruit rinds, boasts antioxidant properties akin to curcumin and also exerts anti-inflammatory, anticancer and neuroprotective effects by inhibiting free radicals, arachidonic acid metabolism, and NO synthesis, suppressing inflammatory mediators like COX-2 and prostaglandins (Deb et al, 2019;Aggarwal et al, 2020). Garcinol show the anticancer potential against various cancers, including colon and breast cancer, is underscored in preclinical studies, along with its neuroprotective effects on memory and cognition (Basha, 2023). Garcinol displays anti-inflammatory effects by regulating signalling pathways and gene expression, inhibiting enzymes like cyclooxygenase-2 and 5-lipoxygenase (Aggarwal et al, 2020;Son et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Exploring the properties of Garcinia indica Linn rind powder and its possible usage in food industry

Awari,

Kumar,

Kaushik

et al. 2024

Int J of Food Sci Tech

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SummaryThe study investigates, the potential utilisation of the Garcinia indica linn rind powder as a valuable and healthy ingredient for food industry. Techno‐functional properties revealed the functional attributes which is crucial for product development. Characterisation of the powder and extract revealed the physical, chemical, and structural properties through FTIR, HPLC, and SEM. Therefore, moisture content (5.45%), ash content (2.80%), fibre content (7.56%), and fat content (9.54%) were reported in G. indica linn rind. Phytochemical analysis indicated significant levels of phenolic and flavonoid compounds, suggesting antioxidant potential, supported by inhibition in the DPPH assay with IC50 value of 485.1 μg/mL. In‐vitro assays revealed inhibitory effects on α‐amylase with IC50 value of 58.43 μg/mL and glucose with an IC50 value of 0.39 μg/mL, indicating potential benefits in blood glucose management and weight control. Overall, G. indica rind powder shows promise as a natural ingredient with diverse applications in functional foods and nutraceuticals, offering potential health benefits through innovative product formulations.

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