Anticancer agents incorporating the N‐acylhydrazone scaffold: Progress from 2017 to present

Abstract

The N-acylhydrazone motif has been shown to be particularly adaptable and promising in the area of medicinal chemistry and drug development, due to its significant biological and pharmacological characteristics. Moreover, N-acylhydrazones are appealing synthetic and biological tools because of their simple and straightforward synthesis. This scaffold has emerged as a fundamental building block for the synthesis of bioactive compounds.Particularly, the N-acylhydrazone scaffold served as a base for the synthesis of a number of potent anticancer agents acting via different mechanisms. An updated summary of the anticancer activity of N-acylhydrazone derivatives described in the literature (from 2017 to 2022) is provided in the current review. It discusses the structure-activity relationship (SAR) of N-acylhydrazone derivatives exhibiting anticancer potential, which could be helpful in designing and developing new derivatives as effective antiproliferative candidates in the future.

Design, Synthesis, and Antifungal Activity of Some Novel Phenylthiazole Derivatives Containing an Acylhydrazone Moiety

“…The above results demonstrated that phenylthiazole is a promising antifungal skeleton for discovering new fungicides. Acylhydrazone compounds possess a wide range of biological activities, such as antifungal [19][20][21][22][23][24], antibacterial [25][26][27], insecticidal [28], antiviral [29,30], and antitumor activities [31,32], which have been widely concerned in the field of pesticides and pharmaceuticals. At present, some compounds containing an acylhydrazone structure have been developed as pesticides or pharmaceuticals, such as benquinox (fungicide) [19,25,29], metaflumizone (insecticide) [20,23,29], and nitrofurazone (antibacterial drug) [31].…”

“…The antifungal activities of all synthesized Acylhydrazone compounds possess a wide range of biological activities, such as antifungal [19][20][21][22][23][24], antibacterial [25][26][27], insecticidal [28], antiviral [29,30], and antitumor activities [31,32], which have been widely concerned in the field of pesticides and pharmaceuticals. At present, some compounds containing an acylhydrazone structure have been developed as pesticides or pharmaceuticals, such as benquinox (fungicide) [19,25,29], metaflumizone (insecticide) [20,23,29], and nitrofurazone (antibacterial drug) [31]. To extend our previous study and find new fungicides, in this study, a series of novel phenylthiazole derivatives containing an acylhydrazone moiety were designed and synthesized based on the principle of active substructure splicing.…”