Anticancer Agents Beyond Cisplatin

doi:10.1002/9781119191377.ch4

Cited by 2 publications

(1 citation statement)

References 198 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, researchers still try to overcome the problem of side effects arising with platinum compounds. There is continuous focus on the development of alternatives to platinum compounds with more specific actions. , In the context of photo dynamic therapy (PDT), ruthenium(II) complexes were found to be interesting thanks to their large Stoke’s shift, absorption in the visible area, and ability to form singlet oxygen (type II photo-oxidation). , In addition to singlet oxygen photoproduction, some of these complexes have been shown to be highly oxidant under light irradiation . These properties have been used to trigger oxidative electron transfer with DNA (type I photo-oxidation).…”

Section: Introductionmentioning

confidence: 99%

Redox-Active Bis-Cyclometalated Iridium(III) Complex as a DNA Photo-Cleaving Agent

et al. 2020

View full text Add to dashboard Cite

The development of new photoactive metal complexes that can trigger oxidative damages to the genetic material is of great interest. In the present paper, we describe the detailed study of a highly photo-oxidant iridium(III) complex that triggers photoinduced electron transfer (PET) with purine DNA bases. The PET has been studied by luminescence and laser flash photolysis experiments. From plasmid DNA agarose gel electrophoresis experiments, we demonstrated the high ability of the iridium complex to induce strand breaks upon light irradiation. Reactive oxygen species (ROS)-specific scavengers and stabilizers were employed to identify that the photocleavage process, the results of which infer singlet oxygen and hydrogen peroxide as the predominant species. To the best of our knowledge, the present work represents one of the few study for highly photo-oxidant bis-cyclometalated iridium(III) complex toward DNA.

show abstract

Section: Introductionmentioning

confidence: 99%

Redox-Active Bis-Cyclometalated Iridium(III) Complex as a DNA Photo-Cleaving Agent

et al. 2020

View full text Add to dashboard Cite

show abstract

Photophysical and Photobiological Properties of Dinuclear Iridium(III) Bis-tridentate Complexes

et al. 2018

View full text Add to dashboard Cite

A series of cationic dinuclear iridium(III) complexes (Ir1-Ir5) bearing terpyridine-capped fluorenyl bridging ligands and different polypyridyl or cyclometalating terminal tridentate ligands were synthesized, characterized, and evaluated for their photophysical and photobiological activities. The influence of the bridging and terminal ligands on the photophysical properties of the complexes was investigated by UV-vis absorption, emission, and transient absorption spectroscopy and simulated by TDDFT calculations. All of the complexes displayed strong bridging-ligand localized visible π,π* absorption and red- or near-infrared phosphorescence as well as broad triplet excited-state absorption across both visible and NIR wavelengths. These triplet states were assigned as predominantlyπ,π* for Ir1 (τ = 3.1 μs) and Ir4 (τ = 48 μs) and CT (charge transfer) for Ir2, Ir3, and Ir5 (τ = 1.7-2.7 μs). Complexes Ir1-Ir5 acted as in vitro photodynamic therapy (PDT) agents toward human SK-MEL-28 melanoma cells when activated with visible light, with submicromolar photocytotoxicity and phototherapeutic indices ranging from 20 to almost 300. The in vitro PDT effects with visible light did not correlate with singlet oxygen (O) quantum yields or DNA photocleaving capacity probed under cell-free conditions. All of the Ir(III) complexes phosphoresced brightly when associated with compromised cells (with or without light treatment) and exhibited photoactivated cellular uptake, highlighting the theranostic potential of this new class of Ir(III) complex photosensitizers.

show abstract

Anticancer Agents Beyond Cisplatin

Cited by 2 publications

References 198 publications

Redox-Active Bis-Cyclometalated Iridium(III) Complex as a DNA Photo-Cleaving Agent

Redox-Active Bis-Cyclometalated Iridium(III) Complex as a DNA Photo-Cleaving Agent

Photophysical and Photobiological Properties of Dinuclear Iridium(III) Bis-tridentate Complexes

Contact Info

Product

Resources

About