Anticancer Activity of Samarium-Coated Magnesium Implants for Immunocompromised Patients

Kannan, Saranya; Rajendran, N.

doi:10.1021/acsabm.0c00400

Cited by 18 publications

(7 citation statements)

References 39 publications

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“…These results are in good agreement with other similar studies regarding the potential antimicrobial activity of samarium ions or samarium based composites [27,29,[53][54][55][56][57][58]. Moreover, the quantitative assays were in good agreement with the results obtained in the qualitative studies performed on 5Sm-HAp suspension, target and coatings.…”

Section: Resultssupporting

confidence: 91%

Antimicrobial Properties of Samarium Doped Hydroxyapatite Suspensions and Coatings

et al. 2020

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Post-implant infections are a major health problem, and it is well-known that treating them with conventional drugs is accompanied by many disadvantages. The development of new biomaterials with enhanced antimicrobial properties are of major interest for the scientific world. The aim of this study was to synthesize and characterize hydroxyapatite doped with Samarium (Ca10−xSmx(PO4)6(OH)2, xSm = 0.05, 5Sm-HAp) suspensions, pellets and coatings. The 5Sm-HAp coatings on Si substrates were obtained by rf magnetron sputtering technique. The different techniques such as ultrasound measurements, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), Glow Discharge Optical Emission Spectroscopy (GDOES), X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM) were used to examine the obtained coatings. The results showed that the doped Sm ions entered the structure of hydroxyapatite successfully and Sm ions was uniformly doped onto the surface of the support. The depth profile curves of Ca, P, O, H, Ce and Si elements exhibit their presence from a surface to substrate interface as function of sputtering time. XPS analysis indicated as calcium-phosphate structures enriched in Sm3+ ions. Furthermore, the antimicrobial properties of the 5Sm-HAp suspensions, targets and coatings were assessed against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923 and Candida albicans ATCC 10231. The results of the antimicrobial assays highlighted that that the samples presented a strong antimicrobial activity against the tested microbial strains. The results showed that the coatings after 48 h of incubation inhibited the growth of all tested microbial strains under the value of 0.6 Log CFU/mL. This study shows that the 5Sm-HAp samples are good candidates for the development of new antimicrobial agents.

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Section: Resultssupporting

confidence: 91%

Antimicrobial Properties of Samarium Doped Hydroxyapatite Suspensions and Coatings

et al. 2020

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“…Ying L. and collaborators, in their study entitled "Long-term biodistribution in vivo and toxicity of radioactive/magnetic hydroxyapatite nanorods", showed that Sm-HA:Gd nanorods exhibit an excellent γ-emission, relaxivity and biocompatibility thus making them suitable for potential applications in the biomedical area (including single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI) [17]. Moreover, according to previous studies, the presence of lanthanide ions on surface of the magnesium alloys induces a superior corrosion resistance, anticancer and antimicrobial activity [16]. The interaction between the implant surface and the surrounding tissue is essential and thus it becomes imperative to obtain coatings with improved biological and antimicrobial properties and finally high-performance implants [18].…”

Section: Introductionmentioning

confidence: 88%

“…Recent studies, have also shown that the biological activity of samarium doped hydroxyapatite (SmHAp) it is strongly influenced by the amount of Sm 3+ that is found in the samples [10][11][12][13][14]. Moreover, has been highlighted that the presence of Sm 3+ in various biomaterials, used in the medical field, increases their anticancer activity [15,16]. Ying L. and collaborators, in their study entitled "Long-term biodistribution in vivo and toxicity of radioactive/magnetic hydroxyapatite nanorods", showed that Sm-HA:Gd nanorods exhibit an excellent γ-emission, relaxivity and biocompatibility thus making them suitable for potential applications in the biomedical area (including single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI) [17].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Physico-Chemical Properties of Antifungal Samarium Doped Hydroxyapatite Thin Films

et al. 2021

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Samarium doped hydroxyapatite (Ca10−xSmx(PO4)6(OH)2, xSm = 0.5, 50SmHAp) is a very promising candidate to be used for different coatings in various dental and orthopedic implants. We report, for the first time, the obtaining of 50SmHAp thin films by a cost-effective method, namely spin coating. Thin films of 50SmHAp on silicon substrate have been analyzed by various techniques such as Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), Metallographic microscopy and Glow Discharge Optical Emission Spectroscopy (GDOES). The stability of 50SmHAp suspension was evaluated by ultrasound measurements. Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were also used to evaluate the 50SmHAp suspension. The antifungal activity of 50SmHAp suspension and coatings was assessed using Candida albicans ATCC 10231 fungal strain (C. albicans). The results of the antifungal assays depicted that both 50SmHAp suspensions and coatings were effective in inhibiting the development of C. albicans fungal cells, thus making them ideal candidates for the development of novel antifungal agents. The obtained results give new perspective for possible applications of 50SmHAp thin films in various medical applications due to their antifungal properties.

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“…Also, in their recent work, Kannan et al [19] highlighted that the presence of a samarium oxide coating on a Mg implant could prevent on the one hand the recurrence of bone tumors and metastases and on the other hand the appearance of post-implant infections.…”

Section: Introductionmentioning

confidence: 99%

Physico-Chemical Properties and In Vitro Antifungal Evaluation of Samarium Doped Hydroxyapatite Coatings

et al. 2020

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Hydroxyapatite (HAp) and samarium doped hydroxyapatite, Ca10−xSmx(PO4)6(OH)2, xSm = 0.05, (5SmHAp), coatings were prepared by sol-gel process using the dip coating method. The stability of 5SmHAp suspension was evaluated by ultrasound measurements. Fourier transform infrared spectroscopy (FTIR) was used to examine the optical characteristics of HAp and 5SmHAp nanoparticles in suspension and coatings. The FTIR analysis revealed the presence of the functional groups specific to the structure of hydroxyapatite in the 5SmHAp suspensions and coatings. The morphology of 5SmHAp nanoparticles in suspension was evaluated by transmission electron microscopy (TEM). Moreover, scanning electron microscope (SEM) was used to evaluate the morphology of nanoparticle in suspension and the morphology of the surface on the coating. The SEM and TEM studies on 5SmHAp nanoparticles in suspension showed that our samples consist of nanometric particles with elongated morphology. The SEM micrographs of HAp and 5SmHAp coatings pointed out that the coatings are continuous and homogeneous. The surface morphology of the 5SmHAp coatings was also assessed by Atomic Force Microscopy (AFM) studies. The AFM results emphasized that the coatings presented the morphology of a uniformly deposited layer with no cracks and fissures. The crystal structure of 5SmHAp coating was characterized by X-ray diffraction (XRD). The surface composition of 5SmHAp coating was analyzed by X-ray photoelectron spectroscopy (XPS). The XRD and XPS analysis shown that the Sm3+ ions have been incorporated into the 5SmHAp synthesized material. The antifungal properties of the 5SmHAp suspensions and coatings were studied using Candida albicans ATCC 10231 (C. albicans) fungal strains. The quantitative results of the antifungal assay showed that colony forming unity development was inhibited from the early phase of adherence in the case of both suspensions and coatings. Furthermore, the adhesion, cell proliferation and biofilm formation of the C. albicans were also investigated by AFM, SEM and Confocal Laser Scanning Microscopy (CLSM) techniques. The results highlighted that the C. albicans adhesion and cell development was inhibited by the 5SmHAp coatings. Moreover, the data also revealed that the 5SmHAp coatings were effective in stopping the biofilm formation on their surface. The toxicity of the 5SmHap was also investigated in vitro using HeLa cell line.

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Anticancer Activity of Samarium-Coated Magnesium Implants for Immunocompromised Patients

Cited by 18 publications

References 39 publications

Antimicrobial Properties of Samarium Doped Hydroxyapatite Suspensions and Coatings

Antimicrobial Properties of Samarium Doped Hydroxyapatite Suspensions and Coatings

Fabrication and Physico-Chemical Properties of Antifungal Samarium Doped Hydroxyapatite Thin Films

Physico-Chemical Properties and In Vitro Antifungal Evaluation of Samarium Doped Hydroxyapatite Coatings

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