Anticancer activity of Pt-selenolate metallacycles

Pal, Manoj K.; Majumdar, Arnab; Vivekananda, K. V.; Wadawale, Amey; Subramanian, M.; Bhuvanesh, N.; Dey, Sandip

doi:10.1039/d2nj03931a

Cited by 2 publications

(4 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results suggest that complexes 2 and 3 exist in trimeric form in both solution and solid state. It is in contrast to our phosphine analogues [Pd(P ∩ P)(4-Sepy)] n (OTf) n , , in which the two products were identified as dimeric and tetrameric complexes in the ratio of 1:0.1 (P ∩ P/dppe) and 1:0.2 (P ∩ P/dppf), which remain in equilibrium.…”

Section: Resultscontrasting

confidence: 96%

“…In solution, the asymmetric isomer slowly converts into the thermodynamically favored symmetric isomer having a uniform charge separation in the cycle. This contrasts with the previously reported phosphine analogues wherein the symmetric dimer and tetramer of Pd and Pt complexes remain in equilibria. , A new undecanuclear Pd cluster was isolated as a minor product in the case of the complex of triflate counteranions. These nonphosphine Pd complexes show excellent catalytic activity with high turnover numbers in aqueous Suzuki coupling reactions and can be reused at least eight times without loss of significant activity.…”

Section: Discussionmentioning

confidence: 99%

“…We have developed the cationic metallacycles of 4-pyridylselenolate and aryl dithiolates, which exhibited excellent catalytic activity in Suzuki, Heck couplings − and carbonylation reactions. , The analogous Pt complexes were found to be stable in cell culture medium and showed high antiproliferative activity . The high stability of the above metallacycles in solution motivated us to design new water-soluble Pd catalysts employing thiolate ligands without introducing any charged functional groups.…”

Section: Introductionmentioning

confidence: 99%

“…This contrasts with our previously reported phosphine-capped Pd and Pt metallacycles derived from 4-pyridyl chalcogenolate, wherein the dimer and tetramer remain in equilibria as major and minor products (Scheme S1). , The catalytic activity of the present Pd complexes was evaluated in Suzuki C–C coupling reactions in water.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Linkage Isomers of Triangular Pd Metallacycles and Catalysis in Aqueous Suzuki Coupling Reaction

Chaudhari,

Wadawale,

Pathak

et al. 2024

Inorg. Chem.

Self Cite

View full text Add to dashboard Cite

The water-soluble trinuclear Pd metallacycles [Pd-(tmeda)(4-Spy)] 3 (X) 3 (tmeda = tetramethylethylenediamine, X = OTf, 2; NO 3 , 3) were synthesized from the ambidentate ligand 4pyridylthiolate (Spy − ) and [Pd(tmeda)X 2 ] in 80 and 70% yield, respectively. Two possible linkage isomers are found in solution (slow interconversion found in the NMR) and in the solid state. Density functional calculations showed that the energy of the isomer with a D 3 -symmetric arrangement of the SPy ligand and all Pd atoms having N∧NPdSN coordination is only 7 kcal/mol lower. When reacting [Pd(tmeda)(NO 3 ) 2 ] with 4,4′-biphenyldithiolate (S 2 bph 2− ), the tetranuclear [{Pd(tmeda)} 4 (μ-S 2 bph) 2 ](NO 3 ) 4 (1) was formed. A new type of undecanuclear Pd cluster was separated as a minor product from an acetone solution of 2 in air. The new complexes represent the first examples of water-soluble Pd metallacycles constructed from a pyridine-thiolate ligand. They show catalytic activity with turnover numbers ranging from 9 to 420 in aqueous Suzuki cross-coupling reactions using phenyl boronic acid and a number of aryl halides. An optimized system gave a TON of 6,900,000 and a TOF of 492,857 h −1 . The catalyst could be reused eight times, and the activity has been attributed to the formation of PdNPs.

show abstract

Section: Resultscontrasting

confidence: 96%

Section: Discussionmentioning

confidence: 99%