Anticancer activity of palladium-based complexes against triple-negative breast cancer

Vojtek, Martin; Marques, M. P. M.; Ferreira, Isabel M. P. L. V. O.; Mota-Filipe, Hélder

doi:10.1016/j.drudis.2019.02.012

Cited by 107 publications

(76 citation statements)

References 91 publications

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“…Palladium(II) complexes have been the subject of extensive investigation because of the structural analogy between Pt II and Pd II complexes. Therefore, efforts have recently been made to design novel anticancer drugs based on palladium compounds . In addition, these compounds have attracted renewed interest due to their wide applications in catalytic processes, construction of chemical sensors, and antibacterial and cytotoxicity usage …”

Section: Introductionmentioning

confidence: 99%

Catalytic and antibacterial properties of 3‐dentate carboxamide Pd/Pt complexes obtained via a benign route

Kiani

Bagherzadeh

Meghdadi

et al. 2020

Applied Organom Chemis

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The complexes PdII(qcq)(OAc) and PtII(qcq)Cl have been synthesized using environmentally benign synthesized ligands and characterized by elemental analyses: Fourier transform infrared spectroscopy, UV–visible spectroscopy, 1H NMR spectroscopy, and X‐ray diffraction. The catalytic activity of the complex was assessed, in different media, for the Mizoroki–Heck coupling reaction for typical aryl halides and terminal olefins under aerobic conditions. Since the base and the solvent were found to influence the efficiency of the reaction, reaction conditions, temperature, time, and the amount of K3PO4 and a mixture of H2O/PEG, were optimized. We found, for the Mizoroki–Heck reaction coupling less reactive aryl chloride derivatives with olefins, promising activity for palladium catalysts. The electrochemical behavior of Hqcq and the Pd(II) complex was investigated by cyclic voltammetry and irreversible PdII/I reductions were observed. Hqcq and the Pd(II) and Pt(II) complexes were also screened for their in vitro antibacterial activity. They showed promising antibacterial activity comparable to that of the antibiotic penicillin.

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Section: Introductionmentioning

confidence: 99%

Catalytic and antibacterial properties of 3‐dentate carboxamide Pd/Pt complexes obtained via a benign route

Kiani

Bagherzadeh

Meghdadi

et al. 2020

Applied Organom Chemis

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“…However, such compounds are typically associated to serious systemic toxicity and acquired resistance (mainly via interaction with glutathione and metallothioneins) ( 3 ). Therefore, other metal complexes have been tested, namely containing ruthenium ( 4 , 5 ), titanium ( 6 ), gold ( 7 ), and palladium, Pd ( 8 – 11 ). Pd(II) compounds have attracted much attention due to the similarity of the metal center to Pt(II) (electronic structure and coordination chemistry) ( 12 , 13 ).…”

Section: Introductionmentioning

confidence: 99%

“…Both mono- and polynuclear Pd-complexes ( i.e. , containing one or more than one metal centers) have been synthesized and characterized ( 8 – 11 , 13 ), along with heterometallic Pt/Pd-complexes (di- and trinuclear), in order to improve antineoplastic response and patient survival ( 15 ). In contrast to mononuclear metal agents, which can only bind (covalently) to one or two sites at their main pharmacological target (DNA bases), polynuclear compounds may interact with DNA at several sites on the double helix ( via short or long range interactions depending on the nature of the ligands), inducing more severe and less repairable damage.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Aspects of Palladium(II) Potential Anti-Cancer Drugs

et al. 2020

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This mini-review reports on the existing knowledge of the metabolic effects of palladium [Pd(II)] complexes with potential anticancer activity, on cell lines and murine models. Most studies have addressed mononuclear Pd(II) complexes, although increasing interest has been noted in bidentate complexes, as polynuclear structures. In addition, the majority of records have reported in vitro studies on cancer cell lines, some including the impact on healthy cells, as potentially informative in relation to side effects. Generally, these studies address metabolic effects related to the mechanisms of induced cell death and antioxidant defense, often involving the measurement of gene and protein expression patterns, and evaluation of the levels of reactive oxygen species or specific metabolites, such as ATP and glutathione, in relation to mitochondrial respiration and antioxidant mechanisms. An important tendency is noted toward the use of more untargeted approaches, such as the use of omic sciences e.g. , proteomics and metabolomics. In the discussion section of this mini-review, the developments carried out so far are summarized and suggestions of possible future developments are advanced, aiming at recognizing that metabolites and metabolic pathways make up an important part of cell response and adaptation to therapeutic agents, their further study potentially contributing valuably for a more complete understanding of processes such as biotoxicity or development of drug resistance.

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“…Breast cancer is the main risk faced for women, as it often leads to death or psychological risks in advanced cases. [1] For these reasons, cancer in the 21st century is the major medical challenge for the scientific community. [2] On the other hand, drug resistance and high cost of cancer drugs are two of the most serious problems facing cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Characterization of new Co(II) complexes and photographic monitoring for their toxic impact on breast cancer cells according to simulation study

Shah

Habeebullah

Saad

et al. 2020

Applied Organom Chemis

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Five new nitrogen‐rich ligands (thioanhydrides) were synthesized and fully characterized. Then, their corresponding Co(II) complexes were prepared and also elucidated by analytical and spectral conformational techniques. First of all, the mono‐negative tri‐dentate mode was proposed with all derivatives towards mono‐nuclear central atom. According to ligand field transitions and magnetic susceptibility values, the square‐planar as well as octahedral geometries were the forms suggested. The presence of water molecules was investigated thermally. For conformational implementation under optimal conditions, energy minimization was carried out and fundamental data were obtained and studied. In silico investigation was carried out using the MOE docking approach to predict the inhibition activity for the new compounds. The Co(II)–3e complex played an excellent inhibitory role. After that and based on preliminary results, in vitro antitumor screening against MCF‐7 cell line was conducted for all Co(II) complexes. The results were consistent with that for standard drug (doxorubicin), and the inhibition feature for the complexes was ranked. Through photographic monitoring, outstanding inhibition activity towards breast cancer spreading was recorded for the Co(II)–3e complex, which coincides well with MOE docking data.

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Anticancer activity of palladium-based complexes against triple-negative breast cancer

Cited by 107 publications

References 91 publications

Catalytic and antibacterial properties of 3‐dentate carboxamide Pd/Pt complexes obtained via a benign route

Catalytic and antibacterial properties of 3‐dentate carboxamide Pd/Pt complexes obtained via a benign route

Metabolic Aspects of Palladium(II) Potential Anti-Cancer Drugs

Characterization of new Co(II) complexes and photographic monitoring for their toxic impact on breast cancer cells according to simulation study

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