Anticancer activity of oxovanadium compounds

Abakumova, O. Yu.; Podobed, O. V.; Belayeva, N. F.; Tochilkin, A. I.

doi:10.18097/pbmc20135903305

Cited by 6 publications

(8 citation statements)

References 29 publications

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“…As shown in Figure 1, the half maximal inhibition concentration (IC 50 ) of vanadyl sulphate on MCF-7 cells was determined to be 85 µM for this length of exposure. Similarly with our results, in L929 mouse fibrosarcoma cells and human hepatocarcinoma HepG2 cells vanadyl sulphate was shown to act as an antiproliferative agent according to dose and time (14). In addition, in another study, A549 human lung adenocarcinoma cells were inhibited with an IC 50 value of 15 µM.…”

Section: Discussionsupporting

confidence: 87%

“…This can be attributed to the dependence of the antiproliferative activity of vanadyl sulphate on the cells type and application dose and time. This property of vanadium and vanadium compounds has been well described in a previous study (14).…”

Section: Discussionsupporting

confidence: 83%

“…In addition, the salt vanadyl sulphate (+4), was found to have high anti-cancer activity under lymphoma, neuroblastoma, T cell, basophilic and eritroleukemia, liver, over, testis, esophagus and bone tumor cell lines (6,12,13). Also, the cytotoxic effect of vanadyl sulphate was reported to be lower in normal cells than in the cancer cells (14). Moreover, a greater accumulation of vanadium in cancerous breast tissues than in normal tissues has been well documented (9).…”

Section: Introductionmentioning

confidence: 99%

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Multi-Mode Assessment Approach on Anti-Cancer Potency of Vanadium on Breast Cancer Cells

Sezer¹

2019

Eur J Biol

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The anti-cancer activities of vanadium and its compounds have been widely investigated in cancer research recently. This is mainly attributed to vanadium and its compounds' near ideal properties for being an anti-cancer agent. Most of the current classical chemotherapeutics used in cancer therapy are known to bring numerous strong side effects. Thus, there is a need to discover new drugs which have mild or no side effects and which are effective in low doses. For the treatment of breast cancer (a disease with a difficult and costly treatment process, high mortality, and which is especially prevalent in woman), novel drugs and approaches are required. With this in mind, this study investigates the potential therapeutic efficacies of vanadyl sulphate, a member of the vanadium compounds with ideal anti-cancer properties such as cytotoxicity, antiproliferative and proapoptotic activities on human breast adenocarcinoma cells (MCF-7) including morphological and ultrastructural changes. Materials and Methods:A MTT colorimetric assay was used for cell viability assessment. Morphological and ultrastructural changes were evaluated using confocal and transmission electron microscopy methods, respectively. The apoptosis stimulating property of vanadyl sulphate was tested under a flow cytometry. And also, cell cycle and proliferation inhibitory effects were examined using the immunohistochemistry technique.Results: Consequently, vanadyl sulphate was detected to be cytotoxic on MCF-7 cells and also damaged the morphology and ultrastructure of cells, stimulated the expression of cyclins and E-cadherin, which in turn triggered apoptotic cell death. Conclusion:According to our findings, vanadyl sulphate was determined to be a strong, potent candidate for anti-cancer drug development and is advisable for further investigations in this area.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

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Multi-Mode Assessment Approach on Anti-Cancer Potency of Vanadium on Breast Cancer Cells

Sezer¹

2019

Eur J Biol

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“…An early study demonstrated that proliferating cells were much more sensitive to V toxicity than non‐proliferating ones. Several studies reported selective cytotoxicity of V complexes in cancer versus non‐cancer cells, but this was not always the case . An emerging topic in the literature is the potential anti‐metastatic activity of V complexes, but the underlying mechanisms are not yet clear.…”

Section: Cytotoxicity Mechanisms Of Vanadium Complexes and Implicatiomentioning

confidence: 99%

“…[67] These results are explained by initial rapid cellular uptake of 5 in parallel with its decomposition in cell culture medium, while cellular uptake of mediumr eactionp roducts of Vw as slow but steady. [24,68] Cytotoxicitys tudies of V IV complexes with carboxylato ligands, e.g., oxodiacetate [69] or l-malate [70] have been reported, but without any stabilityd ata in cell culturemedia. Figure 1.…”

Section: Other Complexes With O-donor Ligandsmentioning

confidence: 99%

Stabilities and Biological Activities of Vanadium Drugs: What is the Nature of the Active Species?

Levina

Lay

2017

Chemistry An Asian Journal

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Diverse biological activities of vanadium(V) drugs mainly arise from their abilities to inhibit phosphatase enzymes and to alter cell signaling. Initial interest focused on anti-diabetic activities but has shifted to anti-cancer and anti-parasitic drugs. V-based anti-diabetics are pro-drugs that release active components (e.g., H VO ) in biological media. By contrast, V anti-cancer drugs are generally assumed to enter cells intact; however, speciation studies indicate that nearly all drugs are likely to react in cell culture media during in vitro assays and the same would apply in vivo. The biological activities are due to V and/or V reaction products with cell culture media, or the release of ligands (e.g., aromatic diimines, 8-hydroxyquinolines or thiosemicarbazones) that bind to essential metal ions in the media. Careful consideration of the stability and speciation of V complexes in cell culture media and in biological fluids is essential to design targeted V-based anti-cancer therapies.

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Photodynamic Applications of New Imidazo[4,5‐f][1,10]phenanthroline Oxidovanadium(IV) Complexes: Synthesis, Photochemical, and Cytotoxic Evaluation

et al. 2020

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Four oxidovanadium (IV) complexes of 1H-imidazo[4,5-f][1,10] phenanthroline analogues with the general formula [VO(L) 2 ] (acac) 2 (1-4) were synthesized and characterized, and their invitro photodynamic activity was evaluated. The complexes showed broad, low-intensity d-d bands at wavelengths from 635 nm to 775 nm in aqueous DMSO. The 1-(pyren-2-yl)-1Himidazo[4,5-f][1,10]phenanthroline oxidovanadium(IV) complex (4) exhibited remarkable photocytotoxicity in HaCaT cells, and cellular apoptosis was confirmed in an AO/EB dual-staining assay. The IC 50 of complex 4 was 8.2 μM under visible light (400-700 nm), but it was less toxic in dark (IC 50 ∼ 70 μM). None of the complexes were less toxic to immortalized lung epithelial cells (IC 50 > 50 μM), which suggested their activity was target-specific. Annexin V-FITC/PI assays performed with 2',7'-dichlorofluorescein diacetate indicated that apoptosis induced by the photoactivated complexes was due primarily to the intracellular generation of singlet oxygen (1 O 2), a reactive oxygen species. Photophysical studies and time-dependent density functional theory (TD-DFT) calculations suggested that the lowest triplet excited states of the complexes were long-lived and facilitated effective intersystem crossing, resulting in the efficient generation of 1 O 2 with good quantum yields (0.49). The remarkable photocytotoxicity of complex 4 indicates that it is promising for the development of next-generation oxidovanadium(IV)-based photochemotherapeutic agents.

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Anticancer activity of oxovanadium compounds

Cited by 6 publications

References 29 publications

Multi-Mode Assessment Approach on Anti-Cancer Potency of Vanadium on Breast Cancer Cells

Multi-Mode Assessment Approach on Anti-Cancer Potency of Vanadium on Breast Cancer Cells

Stabilities and Biological Activities of Vanadium Drugs: What is the Nature of the Active Species?

Photodynamic Applications of New Imidazo[4,5‐f][1,10]phenanthroline Oxidovanadium(IV) Complexes: Synthesis, Photochemical, and Cytotoxic Evaluation

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