Anticancer activity of oxovanadium compounds

Abakumova, O. Yu.; Podobed, O. V.; Belayeva, N. F.; Tochilkin, A. I.

doi:10.1134/s1990750812020023

Cited by 11 publications

(13 citation statements)

References 30 publications

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“…Similarly to 1 and 2, compound 3 adopts a distorted octahedral geometry upon chelation by two bidentate acetylacetonate ligands. The V-O and V O bond lengths for 1-3 are are similar to those observed in related complexes (Singh et al, 2014;Abakumova et al 2012;Meicheng et al, 1983;Silva et al, 2013;Kadirova et al, 2009). Most notable are variances in the V-N bond lengths in the complexes.…”

Section: Structural Commentarysupporting

confidence: 81%

“…Oxovanadium(IV) complexes have been cited as having numerous practical pharmacological applications ranging from anticancer agents to anti-fungal agents and, more recently, as an insulin mimetic (Singh et al, 2014;Abakumova et al, 2012;Amin et al, 2000). Currently investigations are underway to further understand how the oxovanadium complexes perform this wide array of tasks.…”

Section: Chemical Contextmentioning

confidence: 99%

“…Alternatively, studies have shown that it interacts directly with glucose transporters found on the cellular surface (Hiromura et al 2007;Makinen & Brady, 2002). Furthermore, vanadium has been found to have important interactions in DNA repair systems, which have made it a lucrative target for much oncological/pharmacological research (Abakumova et al, 2012;Kostova, 2009).…”

Section: Chemical Contextmentioning

confidence: 99%

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Crystal structures of a series of bis(acetylacetonato)oxovanadium(IV) complexes containing N-donor pyridyl ligands

et al. 2020

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Crystal structures for a series of bis(acetylacetonato)oxovanadium(IV) complexes containing N-donor pyridyl ligands are reported, namely, bis(acetylacetonato-κ2 O,O′)oxido(pyridine-κN)vanadium(IV), [V(C5H7O2)2O(C5H5N)], 1, bis(acetylacetonato-κ2 O,O′)oxido(pyridine-4-carbonitrile-κN)vanadium(IV), [V(C5H7O2)2O(C6H4N2)], 2, and bis(acetylacetonato-κ2 O,O′)(4-methoxypyridine-κN)oxidovanadium(IV), [V(C5H7O2)2O(C6H7NO)], 3, Compounds 1–3 have the formulae VO(C5H7O2)2 L, where L = pyridine (1), 4-cyano-pyridine (2), and 4-methoxypyridine (3). Compound 1 was previously reported [Meicheng et al. (1984). Kexue Tongbao, 29, 759–764 and DaSilva, Spiazzi, Bortolotto & Burrow (2007). Acta Crystallogr., E63, m2422] and redetermined here at cryogenic temperatures. Compounds 1 and 2 as pyridine and 4-cyanopyridine adducts, respectively, crystallize as distorted octahedral structures with the oxo and pyridyl ligands trans to one another. A crystallographic twofold axis runs through the O—V—N bonds. Compound 3 containing a 4-methoxypyridine ligand crystallizes as a distorted octahedral structure with the oxo and pyridyl ligands cis to one other, removing the twofold symmetry seen in the other complexes.

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Section: Structural Commentarysupporting

confidence: 81%

Section: Chemical Contextmentioning

confidence: 99%

Section: Chemical Contextmentioning

confidence: 99%

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Crystal structures of a series of bis(acetylacetonato)oxovanadium(IV) complexes containing N-donor pyridyl ligands

et al. 2020

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“…30 Vanadium complexes have been shown to stimulate the insulin-mediated metabolic pathways and various cellular pathways involved in arresting cancer cell proliferation. 26,48,49 Hence, these complexes have been examined mainly for their insulin mimetic activity and antitumor property. Vanadium has a strong affinity for oxygen (oxophilic) and hence usually forms complexes as the oxidovanadium moiety leading to the formation of oxidovanadium ion.…”

Section: Vanadium-based Complexesmentioning

confidence: 99%

“…Reduced glutathione in cells could reduce V(V) to its tetravalent state which in turn could alter the stability of the complex and its further interactions with the biomolecules and subsequent biological activities. 49 Similarly, V(V) has been found to bind with the transport protein transferrin more readily than albumin. 25 The possibility of dissociation of vanadyl complexes and transformation in their redox status in the biological system is strongly influenced by the pH and ionic environment, which in turn determines the pharmacological importance of the vanadium moiety.…”

Section: Structural Elucidation Ofmentioning

confidence: 99%

Vanadium–Flavonoid Complexes: A Promising Class of Molecules for Therapeutic Applications

Selvaraj

Krishnan

2021

J. Med. Chem.

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Several reports have revealed the superior biological activity of metal ion-flavonoid complexes when compared with the parent flavonoid. Among the different metal ions explored, vanadium and its compounds are in the forefront because of their anticancer and antidiabetic properties. However, the toxicity of vanadium-based ions and their inorganic derivatives limits their therapeutic applications. Complexation of vanadium with flavonoids not only reduces its adverse effects but also augments its biological activity. This Review discusses the nature of coordination in vanadium–flavonoid complexes, their structure–activity correlations, with special emphasis on their therapeutic activities. Several investigations suggest that the superior biological activity of vanadium complexes arise because of their ability to regulate metabolic pathways distinct from those acted upon by vanadium alone. These studies serve to decipher the underlying molecular mechanism of vanadium–flavonoid complexes that can be explored further for generating a series of novel compounds with improved pharmacological and therapeutic performance.

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Impact of added ligand oxides in the sulfoxidation of phenylmercaptoacetic acids with oxovanadium(IV)‐salen complexes

Kavitha¹,

Subramaniam

2023

J of Physical Organic Chem

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The mechanistic aspects covering the effect of added ligand oxides, picoline N-oxide (PicNO), pyridine N-oxide (PyNO), and triphenyl phosphine oxide (TPPO) on the selective sulfoxidation of phenylmercaptoacetic acids to PSAA by H 2 O 2 catalyzed by oxovanadium(IV)-salen complexes have been studied spectrophotometrically in 100% acetonitrile medium. Hydroperoxovanadium(V)-salen is the reactive species in this sulfoxidation.The rate of sulfoxidation is found to be enhanced significantly by increasing the concentrations of PMAA, salen, and H 2 O 2 . The ascertained order of reactivity among the oxovanadium(IV)-salen complexes is 5,5 0dimethyl > unsubstituted salen > 5,5 0 -dichloro. The reaction is found to be impeded by the addition of ligand oxide and introduction of substituents in PMAA. The observed order of rate retardation among ligand oxides is TPPO < PyNO < PicNO. Downward Hammett plot obtained has been rationalized by change in rate-determining step from coordination of PMAA to active species for electron-withdrawing substituents to transfer of oxygen to PMAA for electron-donating substituents within the same mechanism.

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Anticancer activity of oxovanadium compounds

Cited by 11 publications

References 30 publications

Crystal structures of a series of bis(acetylacetonato)oxovanadium(IV) complexes containing N-donor pyridyl ligands

Crystal structures of a series of bis(acetylacetonato)oxovanadium(IV) complexes containing N-donor pyridyl ligands

Vanadium–Flavonoid Complexes: A Promising Class of Molecules for Therapeutic Applications

Impact of added ligand oxides in the sulfoxidation of phenylmercaptoacetic acids with oxovanadium(IV)‐salen complexes

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