Anticancer activity of organotin(IV) carboxylates

Triphenyltin(IV) benzoates with diazenyl/imino scaffold exhibiting remarkable apoptosis mediated by reactive oxygen species

“…The efficacy of triphenyltin(IV) compounds in suppressing tumor cells and advancing apoptosis has been well recognized [24][25][26][27][28][29]. Cytotoxic data for 1 and its pro-ligand HL 1 on HCV29T (human bladder carcinoma) cell line has been reported briefly [40].…”

Synthesis, structure and in vitro cytotoxic activity of two organotin complexes of 2-phenyl-1,2, 3-triazole-4-carboxylic acid

“…Brought to you by | Stockholms Universitet Authenticated Download Date | 8/18/15 11:30 AM that triorganotin compounds are usually more active than the corresponding diorganotin compounds (Hadjikakou and Hadjiliadis, 2009;Amir et al, 2014). In the 0.1% DMSO solution, compound 1 displays the poor anticancer activity due to the high coordination number and steric hindrance around tin, which limit the access of tin to the target (Amir et al, 2014).…”

“…Many researchers have described the preparation and characterization of organotin carboxylates and their activity against tumors, fungi, bacteria and other microorganisms (Shang et al, 2011;Seter et al, 2012;Kaur et al, 2013;Nath et al, 2013Nath et al, , 2014Dong et al, 2014;Wang et al, 2014;Mao et al, 2015). It has been observed that some di-and triorganotin carboxylates show potential as antineoplastic agents (Hadjikakou and Hadjiliadis, 2009;Amir et al, 2014;Carraher and Roner, 2014). The number and nature of the organic groups bonded to the tin center and the carboxylate ligand appear to play an important role in determining their antitumor activity (Hadjikakou and Hadjiliadis, 2009;Amir et al, 2014).…”

“…It has been observed that some di-and triorganotin carboxylates show potential as antineoplastic agents (Hadjikakou and Hadjiliadis, 2009;Amir et al, 2014;Carraher and Roner, 2014). The number and nature of the organic groups bonded to the tin center and the carboxylate ligand appear to play an important role in determining their antitumor activity (Hadjikakou and Hadjiliadis, 2009;Amir et al, 2014). The design and synthesis of new organotin carboxylates by selecting ligands and organotin substrates has been encouraged in order to achieve efficacy.…”

A novel compound of triphenyltin(IV) with N-tert-butoxycarbonyl-l-ornithine causes cancer cell death by inducing a p53-dependent activation of the mitochondrial pathway of apoptosis

“…Triorganotins have demonstrated potential antiproliferative activity in vitro [7] against human tumor cell lines, which has been related to their ability to bind to proteins [8,9]. Special attention is given to organotin(IV) carboxylates with significant cytotoxic properties against different cancer cell lines [10,11]. Some compounds have shown strong apoptosis inducing character in vitro, which can be higher than the corresponding activity of cisplatin or other clinical anticancer drugs [12].…”