Anticancer activity of new organo-ruthenium, rhodium and iridium complexes containing the 2-(pyridine-2-yl)thiazole N,N-chelating ligand

Abstract

KeywordsRuthenium Rhodium Iridium Anticancer agents Bioorganometallic Arene ligands a b s t r a c t

Mono- and dinuclear (η6-arene) ruthenium(II) benzaldehyde thiosemicarbazone complexes: Synthesis, characterization and cytotoxicity

“…This N,S-coordination mode is the most common for thiosemicarbazone ligands, however N,S-coordination in which a four-membered chelate ring is formed has been as well observed [40][41][42][43][44]. The complex adopts the commonly observed piano-stool geometry of many half-sandwich arene ruthenium(II) complexes [29,37,[44][45][46]. In this case, the p-cymene ring forms the seat of the piano-stool, while the bidentate thiosemicarbazone (N,S) and the chlorido ligand form the three legs of the stool.…”

Cellular impact and selectivity of half-sandwich organorhodium(III) anticancer complexes and their organoiridium(III) and trichloridorhodium(III) counterparts

“…In contrast, {(g 5 -C 5 Me 5 )Rh(III)} 2? complexes [5][6][7][8][9] and their Ir(III) analogues [7][8][9][10][11] containing polypyridyl and other chelating aromatic ligands were subsequently found to exhibit IC 50 values in the low micromolar range. Promising cell-deathinducing properties have also been established for Rh(III) complexes containing the facial j 3 S and j 3 N coligands 1,4,7-trithiacyclononane ( [9]aneS 3 ) [12,13] and tris(pyrazolyl)-methane (tpm) [14], as well as for the meridional trichlorido complexes mer-[RhCl 3 (DMSO)(pp)] (DMSO is dimethyl sulfoxide, pp is polypyridyl) [15,16].…”

Ferrocenes as potential anticancer drugs. Facts and hypotheses

“…122,123 Organ oruthenium, rhodium, and iridium half sandwich com plexes with N,N chelating ligands also possess antiproli ferative properties showing cytotoxicity in vitro; however, their cytotoxicities were less than that of cisplatin. 124 The comparative study of anticancer activities of ferro cene derivatives in the neutral (ferrocene as water soluble complex with modified  cyclodextrin, ferrocenylcarb oxylic acid (FcCOOH), and ferrocenylacetic acid (FcCH 2 COOH)) and oxidized forms (ferrocenium (FcH + BF 4 -), ferrocenylcarboxylic acid (FcCOOH + BF 4 -), and ferrocenylacetic acids (FcCH 2 COOH + BF 4 -) tetra fluoroborates) were carried out on in vivo tumor mod els. 85, 86 The oxidized forms of ferrocene were shown to be more active than the neutral ones.…”