Anticancer activity of lactic acid bacteria

Garbacz, Katarzyna

doi:10.1016/j.semcancer.2021.12.013

Cited by 65 publications

(41 citation statements)

References 119 publications

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“…LAB are Gram-positive, usually peroxidase-negative, mildly aerobic, acid-tolerant non-bacilli and cocci; they are found in various habitats, including the digestive tract, oral cavity, pneogaster, and vagina in humans and in ambient ecological niches, including processed dairy and animal products and plant products. LAB are generally regarded as beneficial microorganisms, and some LAB strains, including those belonging to the genera Lactobacillus , Leuconostoc , Pediococcus , Bifidobacteria , Lactococcus , and Streptococcus , are recognized as probiotics [ 10 ]. Probiotics are defined as “live microorganisms that confer health benefits on the host when taken in sufficient quantities” [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Lactic Acid Bacteria: A Promising Tool for Menopausal Health Management in Women

Chen

Wang

et al. 2022

Nutrients

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Menopause is a period during which women undergo dramatic hormonal changes. These changes lead to physical and mental discomfort, are greatly afflictive, and critically affect women’s lives. However, the current safe and effective management measures for women undergoing menopause are insufficient. Several probiotic functions of lactic acid bacteria (LAB) have been recognized, including alleviation of lactose intolerance, protection of digestive tract health, activation of the immune system, protection against infections, improvement of nutrient uptake, and improvement of the microbiota. In this review, we highlight the currently available knowledge of the potential protective effects of LAB on preventing or mitigating menopausal symptoms, particularly in terms of maintaining balance in the vaginal microbiota, reducing bone loss, and regulating the nervous system and lipid metabolism. Given the increasing number of women entering menopause and the emphasis on the management of menopausal symptoms, LAB are likely to soon become an indispensable part of clinical/daily care for menopausal women. Herein, we do not intend to provide a comprehensive analysis of each menopausal disorder or to specifically judge the reliability and safety of complementary therapies; rather, we aim to highlight the potential roles of LAB in individualized treatment strategies for the clinical management of menopause.

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Section: Introductionmentioning

confidence: 99%

Lactic Acid Bacteria: A Promising Tool for Menopausal Health Management in Women

Chen

Wang

et al. 2022

Nutrients

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“…LAB are not only present in foods, but can also be found in the environment as well as in the human gut ( 11 ). It has also been observed that multiple LAB strains, especially Lactobacillus rhamnosus, Lactobacillus casei , and Lactobacillus gasseri , which are considered as probiotics, have been extensively studied considering their health-promoting properties ( 12 , 13 ). Reportedly, LAB strains have the ability to inhibit the multiplication of pathogenic bacteria, increase the efficacy of the gut barrier, exert immunomodulatory effects, and interact with and regulate the function of other organs, including the liver, kidney, and brain ( 11 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus casei SYF-08 Protects Against Pb-Induced Injury in Young Mice by Regulating Bile Acid Metabolism and Increasing Pb Excretion

et al. 2022

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Pb poisoning affects infant growth and development. However, dimercaptosuccinic acid (DMSA) as the current therapy for Pb poisoning exerts relatively significant toxic side effects in infants. Therefore, identifying a non-toxic treatment in this regard is particularly important. In this study, we aimed to investigate the therapeutic effect of an infant feces-derived probiotic strain, Lactobacillus casei SYF-08 (SYF-08), on Pb poisoning in young mice. The Pb levels in the organisms were detected via inductively coupled plasma mass spectrometry, while the therapeutic effect of SYF-08 on Pb-induced neural system damage was explored via the Morris water maze test, hematoxylin-eosin staining, and immunohistochemistry. Additionally, the molecular mechanisms underlying the protective effects of SYF-08 against Pb-induced intestinal damage were also explored via histological staining, 16S rRNA sequencing, untargeted metabolomics, qRT-PCR, and western blotting. In vivo experiments revealed that SYF-08 reduced blood and bone Pb levels and increased urinary Pb excretion. Additionally, SYF-08 alleviated Pb-induced pathological damage to the brain and ultimately improved the learning and cognitive abilities of the young mice. This treatment also restored intestinal microflora dysbiosis, regulated bile acid metabolism, and inhibited the FXR-NLRP3 signaling pathway. It also resulted in fewer adverse events than the DMSA treatment. In conclusion, our results provided valuable insights into the therapeutic role of SYF-08 in Pb poisoning and also suggested that its administration can significantly alleviate the Pb-induced damage.

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“…Their analysis showed that C. butyricum modulated Wnt/β-catenin signaling and the gut microbiota. Summing up the pathways, different probiotics may have a lot of different tumor-suppressing effects, immunomodulation being one of the most important [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Probiotic Supplementation Suppresses Tumor Growth in an Experimental Colorectal Cancer Liver Metastasis Model

Jakubauskas

Jakubauskiene

Leber

et al. 2022

IJMS

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Colorectal cancer (CRC) ranks third in incidence and second in mortality of all cancers worldwide. At the time of primary diagnosis, around 20% of patients already have metastatic CRC and only around 20% are candidates for radical resection. Thus, most of the patients have to undergo chemotherapy (CTx). Due to chemoresistance and side effects, novel treatment additives are crucial for controlling the disease and prolonging patient survival. The aim of this study was to evaluate probiotic supplementation and its antitumorigenic effects in an experimental CRC liver metastasis model. Six-week-old male Wistar rats received either a multispecies probiotic (1.2 × 109 CFU/daily) or placebo mixture. On day 14 of the experiment, rat CRC cells (CC531) were implanted under the liver capsule later treated by FOLFOX CTx. Change in tumor volume was measured by performing micro computed tomography (micro-CT) scanning on experimental days 28 and 34. Additionally, immunohistochemical staining with anti-MPO, anti-Ki67, and anti-CD31 were performed. Tumor apoptosis was evaluated using TUNEL staining. Micro-CT image analysis indicates that probiotic supplementation significantly inhibits tumor growth. No synergistic effects between probiotic supplementation and FOLFOX CTx was observed. Reduced tumor volume was achieved by inhibiting angiogenesis, as tumor microvascular density was significantly lower in rats receiving probiotic supplementation. This study shows that a multispecies probiotic mixture significantly reduces angiogenesis and inhibits CRC liver metastasis growth in an experimental rat model.

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Anticancer activity of lactic acid bacteria

Cited by 65 publications

References 119 publications

Lactic Acid Bacteria: A Promising Tool for Menopausal Health Management in Women

Lactic Acid Bacteria: A Promising Tool for Menopausal Health Management in Women

Lactobacillus casei SYF-08 Protects Against Pb-Induced Injury in Young Mice by Regulating Bile Acid Metabolism and Increasing Pb Excretion

Probiotic Supplementation Suppresses Tumor Growth in an Experimental Colorectal Cancer Liver Metastasis Model

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