Anticancer activity of Kalanchoe tubiflora extract against human lung cancer cells in vitro and in vivo

Abstract

Uncontrolled cell proliferation is a common feature of human cancer. Some of herbal extract or plant-derived medicine had been shown as an important source of effective anticancer agents. We previously reported that an n-BuOH-soluble fraction of Kalanchoe tubiflora has antiproliferative activity by inducing mitotic catastrophe. In this study, we showed that the H O-soluble fraction of Kalanchoe tubiflora (KT-W) caused cell cycle arrest, and senescence-inducing activities in A549 cells. We used 2 dimensional PAGE to analyze the protein expression levels after KT-W treatment, and identified that the energy metabolism-related proteins and senescence-related proteins were disturbed. In vivo experiments showed that the tumor growths in A549-xenografted nude mice were effectively inhibited by KT-W. Our findings implied that KT-W is a putative antitumor agent by inducing cell cycle arrest and senescence. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1663-1673, 2016.

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

“…More recently, the water-soluble fraction of the same extract was shown to cause cell cycle arrest, and to induce senescence in lung cancer A549 cells. At doses of 10 mg and 100 mg/kg b. w. 5 times per week for 6 weeks, the fraction also reduced tumor growth in nude mice [89].…”

El gènere «Kalanchoe» (Crassulaceae) a Catalunya: situació i distribució potencial del tàxon invasor «K. ×houghtoni»

“…Ward, notoespècie que presenta un fort caràcter invasiu i que fou creada artificialment per l'horticultor A.D. Houghton als anys 30 als seus hivernacles de Califòrnia (Houghton, 1935). Kalanchoe destaca, a més a més, pel fet que alguns dels seus tàxons poden causar toxicitat en animals si són ingerits (McKenzie & Dunster, 1986;Smith, 2004), tot i que també s'han indicat possibles usos medicinals (Milad et al, 2014;Bogucka-Kocka et al, 2016;Hsieh et al, 2016).…”

Excavatolide B inhibits nonsmall cell lung cancer proliferation by altering peroxisome proliferator activated receptor gamma expression and PTEN/AKT/NF‐Kβ expression

“…Lung cancer is the end result of lung carcinogenesis and is the leading cause of cancer death around the world; in Asia, more than 86,000 new lung cancer cases were diagnosed every year in Japan and 9,000 cases in Taiwan [Bioworld Asia estimates] (Landis et al, ; Lin et al, ; Wang et al, ; Hsieh et al, ; Siegel et al, ). Particularly in lung cancer, adenocarcinoma is one of the major histological types that show resistant to most of the drugs.…”

“…Plants and medicinal fungus possess various bioactive components, therefore many plants have been investigated to identify their potential role as an antioxidants, cancer preventative and therapeutic agents (Aravindaram and Yang, ; Hsieh et al, ). Previous epidemiological studies have shown that the consumption of vegetables, fruits and tea is associated with a low risk of cancer (Block et al, ; Pandey and Rizvi, ).…”

“…Previous epidemiological studies have shown that the consumption of vegetables, fruits and tea is associated with a low risk of cancer (Block et al, ; Pandey and Rizvi, ). More than 60% of anticancer drugs have originated from natural materials, such as plants, microbes, and marine organisms (Newman et al, ; Hsieh et al, ). Compounds derived from sponges, algae, mollusks, and other marine organisms are being tested for their therapeutic effects against cancer, anti‐inflammatory, anti‐viral activities, as well as immune modulation and analgesic agents (Amador et al, ; Newman and Cragg, ; Butler, ; Dyshlovoy and Honecker, ).…”