Anticancer activities of some newly synthesized pyridine, pyrane, and pyrimidine derivatives

Synthesis of Novel Steroidal N-Substituted Pyrimidine-2, 4-Diones: A New Entry to Steroidal Azaheterocycles.

“…1 (TLC) the reaction mass was cooled to room temperature and petroleum ether (25 ml) was added. It was purified to afford viscous oil.…”

“…[1] Many steroidal heterocyclic compounds have been reported to possess various therapeutic activities. [2,3] Condensed pyrimidine derivatives have been reported as anti-tumour [4] , anti-neoplastic [5] ,…”

4-[Bis(2-chloroethyl)amino]benzaldehyde

“…Molecules containing heterocyclic substructures continue to be attractive targets for synthesis since they often exhibit diverse and important biological properties. For example, pyridine is used in the pharmaceutical industry as a raw material for various drugs, vitamins and fungicides, and as a solvent (Shinkai et al, 2000;Jansen et al, 2001;Amr et al, 2006) while 2-amino-3-cyanopyridines have been identified as IKK-inhibitors (Murata et al, 2003).…”

Synthesis, Docking Studies and Anticancer Activity of New Substituted Pyrimidine and Triazolopyrimidine Glycosides

“…Different nucleoside analogs incorporating substituents at the C-5 position in the heterocyclic base, especially in the 2-deoxyuridine type, were investigated to have interesting biological activities as antiviral and anticancer agents (Srinivasan et al, 20101;McGuian et al, 2000;Yoo et al, 2002;Hannah et al, 2000;Khan and Grinstaff, 1998). The above findings and our interest in glycosyl heterocycles synthesis with biological activity research field El-Sayed et al, 2009;Amr et al, 2006;ElSayed et al, 2016) promoted us to design and synthesize new pyrimidine and triazolopyrimidine glycosides with acetylated or free hydroxyl sugar moieties and acyclic analogs bearing ether or terminal hydroxyl studying their anticancer activity against a number of cancer cells.…”