Antibody to neural cell adhesion molecule can disrupt the migration of luteinizing hormone‐releasing hormone neurons into the mouse brain

Schwanzel‐Fukuda, Marlene; Reinhard, Günter; Abraham, Suzanne; Crossin, Kathryn L.; Edelman, Gerald M.; Pfaff, Donald W.

doi:10.1002/cne.903420203

Cited by 59 publications

(19 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Migration of cells from the olfactory placode into the brain has frequently been described (Mendoza et al 1982;Monti-Graziadei 1992; for reviews, see Tarozzo et al 1995a;Schwanzel-Fukuda 1999). Although a true migration is difficult to prove experimentally, there seems to be some evidence for gonadotropin-releasing hormone (GnRH)-expressing cells (Wray et al 1989;Schwanzel-Fukuda et al 1989;Murakami et al 1992;Schwanzel-Fukuda et al 1994). The observation that some extraepithelial cells extend cytoplasmic processes (Fig.…”

Section: Discussionmentioning

confidence: 95%

Extraepithelial cells expressing distinct olfactory receptors are associated with axons of sensory cells with the same receptor type

Conzelmann

Lévai

Breer

et al. 2002

Cell and Tissue Research

View full text Add to dashboard Cite

During critical phases of mouse development, axons from olfactory sensory neurons grow out of the nasal neuroepithelium and navigate through the connective mesenchyme tissue towards their targets in the developing telencephalic vesicle. Between embryonic days E11 and E16, populations of cells are located in the mesenchyme which express distinct olfactory receptor genes along with the olfactory marker protein (OMP); thus they express markers characteristic for mature olfactory sensory neurons. These extraepithelial cells are positioned along the axon tracts, and each population expressing a given receptor gene is specifically associated with the axons of those olfactory sensory neurons with the same receptor type. The data suggest that they either might be guide posts for the outgrowing axons or migrate along the axons into the brain.

show abstract

Section: Discussionmentioning

confidence: 95%

Extraepithelial cells expressing distinct olfactory receptors are associated with axons of sensory cells with the same receptor type

Conzelmann

Lévai

Breer

et al. 2002

Cell and Tissue Research

View full text Add to dashboard Cite

show abstract

“…Likewise, enzymatic removal of PSA from cell surfaces in the neurohypophysis prevented stimulation-related induction and reversal of axon and glial changes but had no effect once remodeling had occurred (115). There is strong, constant expression of PSA-NCAM in the GnRH system of rodents (16,80,162), sheep (198), and primates (144) where it also appears essential for astrocytic-neuronal plasticity, since removal of PSA inhibited the onset of astrocytic and synaptic changes associated with reproductive status (80,162).…”

Section: A Permissive Molecular Factorsmentioning

confidence: 93%

Activity-Dependent Structural and Functional Plasticity of Astrocyte-Neuron Interactions

Theodosis¹,

Poulain²,

Oliet³

2008

Physiological Reviews

454

350

View full text Add to dashboard Cite

Observations from different brain areas have established that the adult nervous system can undergo significant experience-related structural changes throughout life. Less familiar is the notion that morphological plasticity affects not only neurons but glial cells as well. Yet there is abundant evidence showing that astrocytes, the most numerous cells in the mammalian brain, are highly mobile. Under physiological conditions as different as reproduction, sensory stimulation, and learning, they display a remarkable structural plasticity, particularly conspicuous at the level of their lamellate distal processes that normally ensheath all portions of neurons. Distal astrocytic processes can undergo morphological changes in a matter of minutes, a remodeling that modifies the geometry and diffusion properties of the extracellular space and relationships with adjacent neuronal elements, especially synapses. Astrocytes respond to neuronal activity via ion channels, neurotransmitter receptors, and transporters on their processes; they transmit information via release of neuroactive substances. Where astrocytic processes are mobile then, astrocytic-neuronal interactions become highly dynamic, a plasticity that has important functional consequences since it modifies extracellular ionic homeostasis, neurotransmission, gliotransmission, and ultimately neuronal function at the cellular and system levels. Although a complete picture of intervening cellular mechanisms is lacking, some have been identified, notably certain permissive molecular factors common to systems capable of remodeling (cell surface and extracellular matrix adhesion molecules, cytoskeletal proteins) and molecules that appear specific to each system (neuropeptides, neurotransmitters, steroids, growth factors) that trigger or reverse the morphological changes.

show abstract

“…Neural cell adhesion molecule (NCAM) is expressed by cells of the olfactory epithelium and is present along the olfactory nerve of the mouse [44,605 45] and chick [27,46]; however, NCAM was not re stricted to areas containing GnRH neurons and fibers. While injections of an antiserum to NCAM were reported to inhibit the migration of GnRH neurons in nasal sep tum of the mouse [47], it is not clear whether NCAM pro vides a permissive environment or plays a more active role.…”

Section: Discussionmentioning

confidence: 99%

The Ontogeny of Gonadotropin-Releasing Hormone Neurons in the Chick

Sullivan¹,

Silverman²

1993

Neuroendocrinology

View full text Add to dashboard Cite

The origin of gonadotropin-releasing hormone (GnRH) neurons in the olfactory placode and their subsequent migration into the central nervous system (CNS) has been described in several species. The current study was undertaken to delineate the time course and route of GnRH neuronal migration in the chick using antisera generated against both the mammalian form of GnRH (LR1) and a specific chicken GnRH (cGnRH I). Chicks aged E4.5 through day of hatching were processed for GnRH immunocytochemistry. Under the incubation conditions employed in this study, GnRH neurons first appeared on E4.5 in the olfactory epithelium. GnRH neurons exit from the olfactory epithelium and follow the extracranial course of the olfactory nerve to the anterior pole of the developing forebrain. Within the nerve, cells are in close apposition to each other. By E5, cells had reached the surface of the telencephalon. Upon entering the CNS, the GnRH neurons dispersed within the neuropil and continued their migration as individuals. As development progressed, GnRH neurons migrated dorsally and caudally within the brain and reached their adult positions by E12. GnRH axons were detected in the vicinity of GnRH cell bodies with the cGnRH I antiserum as early as E4.5; however, GnRH axons did not reach the median eminence until E14. These results extend earlier reports in mammal and chick on the extracranial origin of GnRH neurons and their path of entry into and dispersion within the CNS.

show abstract

Antibody to neural cell adhesion molecule can disrupt the migration of luteinizing hormone‐releasing hormone neurons into the mouse brain

Cited by 59 publications

References 31 publications

Extraepithelial cells expressing distinct olfactory receptors are associated with axons of sensory cells with the same receptor type

Extraepithelial cells expressing distinct olfactory receptors are associated with axons of sensory cells with the same receptor type

Activity-Dependent Structural and Functional Plasticity of Astrocyte-Neuron Interactions

The Ontogeny of Gonadotropin-Releasing Hormone Neurons in the Chick

Contact Info

Product

Resources

About