Antibody to Lymphadenopathy-Associated Virus in Haemophiliacs With and Without Aids

Anti-LAV and Concentrate Consumption in Italian Hemophiliacs

“…The anti-LAV prevalence rate is proportional to the total dose of concentrate received during the last 4-year period, in agreement with other data (2,3). The observed association of anti-LAV with abnormalities of T-lymphocyte subsets is likely to reflect the association of both the parameters with concentrate consumption (4).…”

Lymphocyte subset ratios and factor VIII usage in haemophilia.

“…Some patients, however, treated with prothrombin complex concentrates have been shown to have abnormal T4:T8 ratios,8 9 14 and the finding that small numbers of patients with haemophilia B treated with factor IX concentrates were negative for lymphadenopathy associated virus antibody (and had normal cellular immunity) needs clarification. 23 It has also been suggested that repeated antigenic challenge by factor VIII concentrate may cause the observed immunological abnormalities.30 Differences in the fractionation procedures may lead to immunochemical differences between factor VIII and prothrombin complex concentrates,13 and differences in the concentration of the HLA related protein B2 microglobulin have been implicated.31…”

Occurrence of AIDS in Hemophiliacs in Japan

“…4,17 Use of these products will hopefully prevent the infection of hemophiliacs with AIDS in the future. However, many patients with hemophilia are seropositive to HTLV-III, 10,11,14 indicating these patients have already been infected with the virus. Of 50 of our hemophilia patients examined for antibody to HTLV-III, 23 (46%) were positive, including the two patients with AIDS in this report.…”