Antibody to hepatitis A virus after overt and asymptomatic hepatitis A infection

Prikazchikov, S. A.; Balayan, M. S.

doi:10.1007/bf00152715

Cited by 1 publication

(2 citation statements)

References 10 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of residual maternal antibody can certainly be excluded since it has been convincingly proved that such antibody disappears by the end of the first year of life (17). On the other hand, actively acquired anti~HAV following overt or asymptomatic hepatitis A infection continue to persist at high levels for a relatively long time (5,15). In the majority of seropositive children from the present survey anti-HAV titres did not decrease at least during the 8-month observation period.…”

mentioning

confidence: 51%

“…The period in which a seasonal rise in hepatitis A m o r b i d i t y generally occurs was included. The lowest p r o p o r t i o n of anti-HAV s,eropositive children was consistently found in the 2-6 year age groupe (13,18,15), while the highest incidence of hepatitis A registered in recent years, accompanied by a sharp increase, in the p r o p o r t i o n of anti-HAV seropositives was seen in children f r o m 7 to 14 years. The whole region was previously considered to be -endemic ,., for hepatitis A.…”

Section: Introductionmentioning

confidence: 88%

See 1 more Smart Citation

Shifts in the rates and levels of antibody to hepatitis A virus associated with hepatitis A infection in children's communities

Prikazchikov

Balayan

1987

Eur J Epidemiol

Self Cite

View full text Add to dashboard Cite

In order to investigate the shift in the rates and levels of antibody to hepatitis A virus, 567 children in 20 isolated groups of five day-care centers were observed over a period of 8 months during which the seasonal rise in hepatitis A morbidity occurs. Increases in the proportion of seropositive ranging from 5 to 37% were demonstrated in 6 groups, and were always associated with the occurrence of either overt or sub-clinical hepatitis A infection. High rates of seropositivity were also noted in the groups in which cases of hepatitis A had been registered prior to the period of observation. In some children with low and medium antibody levels, antibody titres showed further increases after reinfection. A substantial part of children retained low antibody titres during the entire period of observation, and eight previously sero-negative children developed low antibody levels after asymptomatic hepatitis A infections. In one group the spread of hepatitis A infection (clinical and asymptomatic) was prevented by the administration of commercially available immunoglobulin immediately after the discovery of an infected food handler. Passive antibodies were found in previously sero-negative children, and these antibodies dropped to undetectable levels two months after administration.

show abstract

mentioning

confidence: 51%

Section: Introductionmentioning

confidence: 88%