Antibody Titers to Desmogleins 1 and 3 in a Patient With Paraneoplastic Pemphigus Associated With Follicular Dendritic Cell Sarcoma

Seishima, Mariko; Oda, Makiko; Oyama, Zuiei; Yoshimura, Tomoaki; Yamazaki, Futoshi; Aoki, Takahiko; Nei, Mariko; Hashimoto, Takashi

doi:10.1001/archderm.140.12.1500

Cited by 30 publications

(15 citation statements)

References 19 publications

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“…A recent study utilizing the PNP model mouse suggests that the fatal pulmonary symptoms in patients are most likely due to ectopic expression of Dsg3 and other epidermal antigens (Hata, et al, 2013). Autoantibodies in PNP are directed against multiple desmosomal proteins, including Dsgs, Dscs, desmoplakin and plakophilins (Futei, et al, 2003, Gallo, et al, 2014, Hashimoto, et al, 1995a, Lambert, et al, 2010, Seishima, et al, 2004). Similar to other forms of pemphigus, blistering in this disease can be attributed to autoantibodies directed against Dsgs (Amagai, et al, 1998, Nishifuji, et al, 2007, Saleh, et al, 2012), particularly the Dsg3 EC2-3 domains (Saleh, et al, 2012).…”

Section: Acquired Desmosomal Diseasesmentioning

confidence: 99%

Desmosomes in acquired disease

Stahley

Kowalczyk

2015

Cell Tissue Res

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Desmosomes are cell-cell junctions that mediate adhesion and couple the intermediate filament cytoskeleton to sites of cell-cell contact. This architectural arrangement functions to integrate adhesion and cytoskeletal elements of adjacent cells. The importance of this robust adhesion system is evident in numerous human diseases, both inherited and acquired, that occur when desmosome function is compromised. This review focuses on autoimmune and infectious diseases that impair desmosome function. In addition, we discuss emerging evidence that desmosomal genes are often misregulated in cancer. The emphasis of our discussion is placed on how human diseases inform our understanding of basic desmosome biology, and in turn, how fundamental advances in the cell biology of desmosomes may lead to new treatments for acquired diseases of the desmosome.

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Section: Acquired Desmosomal Diseasesmentioning

confidence: 99%

Desmosomes in acquired disease

Stahley

Kowalczyk

2015

Cell Tissue Res

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“…Four among these cases complicated a Castleman's disease [3,10]. A special form of pemphigus called paraneoplastic pemphigus was described in association with FDCT arising or not from Castleman's disease [16]. In 1985, at the time when the diagnosis of pemphigus vulgaris was made in our patient, the paraneoplastic pemphigus was not yet described and the autoantibodies specific for this disease were not characterized.…”

Section: Discussionmentioning

confidence: 91%

Follicular dendritic cell tumor of the mediastinum: expression of fractalkine and SDF-1α as mast cell chemoattractants

et al. 2006

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Follicular dendritic cell tumor (FDCT) is a rare tumor mainly located in laterocervical lymph nodes. We report one case of mediastinal FDCT associated with a history of bullous skin disease and clinically obvious immunosuppression. This tumor was characterized by heavy mast cell infiltration. Mast cells were in close relationship with tumor cells as demonstrated by ultrastructural examination and their presence are probably related with the strong expression of mast cell chemoattractants as fraktalkine and stromal cell-derived factor-1alpha by tumor cells. The long follow-up period of more than 17 years allowed to us assess the relatively indolent evolution of this tumor characterized by three slowly growing local recurrences without metastasis.

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“…Antibodies against desmoglein 1 and 3, which are known to be target antigens of classic pemphigus vulgaris, were suggested to play some role in the initial stages of development of PNP [11]. More recently, due to the marked cellular inflammation in many cases and PNP cases without detectable autoantibodies, not only humoral immunity but the role of T lymphocytes has also been discussed [12].…”

Section: Discussionmentioning

confidence: 99%

A Case Report of Paraneoplastic Pemphigus Associated with Esophageal Squamous Cell Carcinoma

Cho

Kim

et al. 2013

Cancer Res Treat

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Paraneoplastic pemphigus is an autoimmune blistering and erosive mucocutaneous syndrome associated with underlying neoplasm. It is primarily associated with lymphoproliferative disorders, and uncommonly with malignancies of epithelial origin. We report on a case of a 68-year-old male who presented with whole body bullous and erosive skin lesions. Findings on upper gastrointestinal endoscopy and skin biopsy revealed esophageal squamous cell carcinoma and paraneoplastic pemphigus. Palliative chemotherapy and systemic glucocorticoid were started, however, the patient died of overwhelming sepsis on the ninth day of chemotherapy. This case demonstrates that paraneoplastic pemphigus can occur in esophageal squamous cell carcinoma and could be a cause of morbidity.

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Antibody Titers to Desmogleins 1 and 3 in a Patient With Paraneoplastic Pemphigus Associated With Follicular Dendritic Cell Sarcoma

Cited by 30 publications

References 19 publications

Desmosomes in acquired disease

Desmosomes in acquired disease

Follicular dendritic cell tumor of the mediastinum: expression of fractalkine and SDF-1α as mast cell chemoattractants

A Case Report of Paraneoplastic Pemphigus Associated with Esophageal Squamous Cell Carcinoma

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