Antibody titers in turkeys increase after multiple booster vaccinations with an attenuated Salmonella live vaccine

Abstract

ObjectiveHuman Salmonellosis is one of the most frequently reported foodborne zoonoses in the European Union. The most common source of human infections is the consumption of poultry products. Besides management and hygiene practices vaccination of poultry livestock is seen as one way to reduce Salmonella infections in humans. Turkey flocks in Europe are frequently infected with Salmonella and until recently there was no live vaccine for turkeys available. The aim of the present study was to examine the development of humoral antibodies after repeated vaccination with a bivalent live Salmonella vaccine containing attenuated Salmonella Typhimurium and Salmonella Enteritidis strains. Furthermore the colonization of the caecum with the vaccine strains and their spread to liver and spleen as well as the course of their fecal excretion was observed.ResultsAntibody production was hardly detectable after the first vaccination but increased after booster vaccinations. Both the Salmonella Enteritidis and the Salmonella Typhimurium vaccine strain were reisolated from caecum contents and organ samples. After booster vaccinations the re-isolation rates were reduced. The shedding of the vaccine strains was most pronounced after the first vaccination.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3462-y) contains supplementary material, which is available to authorized users.

Safety of bivalent live attenuated Salmonella vaccine and its protection against bacterial shedding and tissue invasion in layers challenged with Salmonella

“…It is noteworthy that SE dominated the egg-associated Salmonella outbreaks ( Patrick et al., 2004 ) because of their supplementary ability to colonize the ovary and oviduct, leading to in-egg contaminations ( Gast et al., 2013 ). On the other hand, ST was reported to cause severe diseases in very young chickens, contributing to public health issues and significant economic losses ( Hesse et al., 2018 ). Based on the recent rise of those zoonotic Salmonella infections in layers, a safe and effective prophylactic that protects them from bacterial shedding and organ invasions by pathogenic Salmonella without compromising the regular productions was demanded.…”

Effect of Antibiotics on the Colonization of Live Attenuated Salmonella Enteritidis Vaccine in Chickens

“…Experts focused on the risk to consumers posed by Salmonella Enteritidis, the bacterium responsible for causing the highest number of eggborne outbreaks in the EU. At the same time, the protection of Salmonella Typhimurium from very young chicks may lead to serious diseases and huge economic losses in the early stages of life (18). At present, vaccine programs based on inactivated vaccines and live vaccines have been used to control Salmonella (19).…”

“…After a robust vaccination program, the immunity of chicks infected with Salmonella to reinfection was significantly improved. In general, live vaccines are considered more suitable for stimulating cellular immunity and have a protective effect on poultry products ( 18 , 22 ). Some live vaccines thus achieve a double mechanism of protection by increasing mucosal immunity and producing specific bacterial competition against any wild-type strain of Salmonella ( 23 , 24 ).…”

Dietary Inclusion of a Saccharomyces cerevisiae-Derived Postbiotic Is Associated with Lower Salmonella enterica Burden in Broiler Chickens on a Commercial Farm in Honduras

“…In poultry, vaccination with live, attenuated strains of Salmonella are commonplace and continue to evolve with variable efficacy [ 17 , 18 ]. While vaccination may confer early protection against wild type Salmonella colonization, durability of protection may decrease over time, requiring booster administration [ 18 , 19 , 20 ]. Feed additive solutions that can be continually coadministered throughout the life of the animal while promoting gut health, performance, and protection against pathogen colonization are therefore attractive.…”