Antibody status to HHV-6 in children with leukaemia

Salonen, Matteus; Siimes, Martti A.; Salonen, Eeva‐Marjatta; Vaheri, Antti; Koskiniemi, M.

doi:10.1038/sj.leu.2402437

Cited by 24 publications

(15 citation statements)

References 36 publications

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“…The test was initially developed for our leukaemia series [10]. Now we had a possibility to use seroconversions as the 'gold standard' to verify primary infection.…”

Section: Discussionmentioning

confidence: 99%

IgM and avidity of IgG antibodies in primary HHV-6 infections

Salonen

Vaheri

Koskiniemi

2008

Scandinavian Journal of Infectious Diseases

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“…The test was initially developed for our leukaemia series [10]. Now we had a possibility to use seroconversions as the 'gold standard' to verify primary infection.…”

Section: Discussionmentioning

confidence: 99%

IgM and avidity of IgG antibodies in primary HHV-6 infections

Salonen

Vaheri

Koskiniemi

2008

Scandinavian Journal of Infectious Diseases

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“…The largest study showed significant higher titres of HHV-6 antibodies in patients with acute myeloid leukemia, but not with acute lymphoblastic leukemia 27. Salonen et al28 found that 40% of children with leukemia had IgM antibodies to HHV-6 compared to 7.7% of age- and sex-matched children with various neurological diseases. However, molecular studies have so far failed to show a higher rate of HHV-6 DNA in peripheral blasts from children with acute lymphoblastic leukemia compared with healthy subjects 29.…”

Section: β Herpesvirusesmentioning

confidence: 99%

HHVs AND LYMPHOPROLIFERATIVE DISORDERS

Quadrelli

Barozzi²,

Riva³

et al. 2011

Mediterr J Hematol Infect Dis

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Similarly to Epstein-Barr virus (EBV), the human herpesvirus-8 (HHV-8) is a γ-herpesvirus, recently recognized to be associated with the occurrence of rare B cell lymphomas and atypical lymphoproliferations, especially in the human immunodeficiency virus (HIV) infected subjects. Moreover, the human herpesvirus-6 (HHV-6), a β-herpesvirus, has been shown to be implicated in some non-malignant lymph node proliferations, such as the Rosai Dorfman disease, and in a proportion of Hodgkin’s lymphoma cases. HHV-6 has a wide cellular tropism and it might play a role in the pathogenesis of a wide variety of human diseases, but given its ubiquity, disease associations are difficult to prove and its role in hematological malignancies is still controversial. The involvement of another β-herpesvirus, the human cytomegalovirus (HCMV), has not yet been proven in human cancer, even though recent findings have suggested its potential role in the development of CD4+ large granular lymphocyte (LGL) lymphocytosis. Here, we review the current knowledge on the pathogenetic role of HHV-8 and human β-herpesviruses in human lymphoproliferative disorders.

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“…The largest study showed a significant association of HHV‐6 antibody titers may be higher in patients with acute myeloid leukemia but not with acute lymphoblastic leukemia [Levine et al, 1992a]. Salonen et al 2002 found that 40% of children with leukemia had IgM antibodies to HHV‐6 compared to 7.7% of age‐ and sex‐matched children with various neurological diseases. However, molecular studies have so far failed to show a higher rate of HHV‐6 DNA in peripheral blasts from children with acute lymphoblastic leukemia compared with healthy subjects [Barozzi et al, 1995].…”

Section: Hhv‐6 and Malignanciesmentioning

confidence: 99%