Antibody responses to neonatal immunisation in calves

Husband, Alan J.; Lascelles, A. K.

doi:10.1016/s0034-5288(18)33614-2

Cited by 79 publications

(55 citation statements)

References 16 publications

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“…It is also possible that colostrum-fed domestic animals actively produce antibodies in response to vaccination in the presence of maternal antibodies, but these endogenous antibodies may not be sufficient in quantity to result in a detectable change in serum titer compared with the residual titer of maternal antibodies in these animals. This notion is supported by studies using gnotobiotic (Gn) pigs and colostrum-deprived calves, which suggest that even in the absence of maternal antibodies, very young animals mount antibody responses of low magnitude (71)(72)(73). Therefore, lack of seroconversion in colostrum-fed domestic animals is not definitive evidence of the absence of active immune responses to vaccines.…”

Section: Immune Potential Of Newborn Animalsmentioning

confidence: 99%

Strategies for Design and Application of Enteric Viral Vaccines

Chattha

Roth

Saif

2015

Annu. Rev. Anim. Biosci.

113

117

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Enteric viral infections in domestic animals cause significant economic losses. The recent emergence of virulent enteric coronaviruses [porcine epidemic diarrhea virus (PEDV)] in North America and Asia, for which no vaccines are available, remains a challenge for the global swine industry. Vaccination strategies against rotavirus and coronavirus (transmissible gastroenteritis virus) infections are reviewed. These vaccination principles are applicable against emerging enteric infections such as PEDV. Maternal vaccines to induce lactogenic immunity, and their transmission to suckling neonates via colostrum and milk, are critical for early passive protection. Subsequently, in weaned animals, oral vaccines incorporating novel mucosal adjuvants (e.g., vitamin A, probiotics) may provide active protection when maternal immunity wanes. Understanding intestinal and systemic immune responses to experimental rotavirus and transmissible gastroenteritis virus vaccines and infection in pigs provides a basis and model for the development of safe and effective vaccines for young animals and children against established and emerging enteric infections.

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Section: Immune Potential Of Newborn Animalsmentioning

confidence: 99%

Strategies for Design and Application of Enteric Viral Vaccines

Chattha

Roth

Saif

2015

Annu. Rev. Anim. Biosci.

113

117

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“…Colostral derived immunoglobulins can suppress neonatal immunity by various mechanisms (Banks, 1982). Previous studies demonstrated that colostrum deprived calves produced IgG and IgA earlier than colostrum fed calves (Husband and Lascelles, 1975). The mechanism of suppression of the immune system by the colostralderived immunoglobulins can be either antigen specific or non-antigen specific (Banks, 1982).…”

Section: Introductionmentioning

confidence: 99%

Comparison of serum immunoglobulin G half-life in dairy calves fed colostrum, colostrum replacer or administered with intravenous bovine plasma

Murphy

Hagey

Chigerwe

2014

Veterinary Immunology and Immunopathology

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In calves, passive immunity of immunoglobulins can be acquired through ingestion of colostrum or colostrum replacers. Plasma can been used to supplement immunoglobulins in healthy or sick calves. Serum half-life of colostral derived immuglobulin G (IgG) is estimated to be 20 days. Half-life of IgG is important in determining response to antigens and timing of vaccination in calves. To date studies evaluating half-life of colostrum replacer or plasma derived IgG are lacking. The objectives of this study were to compare the serum half-life of IgG derived from colostrum, colostrum replacer and plasma in dairy calves reared up to 35 days of age. Thirty Jersey calves were randomly assigned to receive colostrum or colostrum replacer by oroesophageal tubing or plasma by intravenous administration. Serum samples were collected at 2, 5, 7, 10, 14, 21, 28 and 35 days. Serum IgG concentrations were determined by radial immunodiffusion. The results indicated that half-life for IgG in colostrum fed (28.5 days) or plasma transfused calves (27.3 days) was longer than colostrum replacer fed calves (19.1 days). Further studies are required to evaluate pathogen specific immunoglobulins in order to recommend vaccination timing in calves fed colostrum replacers.

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“…Calves do not start producing endogenous IgM until four days after birth, which does not reach functional levels until eight days after birth. IgA, IgG 1 and IgG 2 don’t reach appreciable levels until 16 to 32 days after birth (Husband and Lascelles 1975) . Adult levels of antibodies are not reached until approximately four months of age (Husband and Lascelles 1975).…”

Section: Development Of the Immune Systemmentioning

confidence: 99%

“…IgA, IgG 1 and IgG 2 don’t reach appreciable levels until 16 to 32 days after birth (Husband and Lascelles 1975) . Adult levels of antibodies are not reached until approximately four months of age (Husband and Lascelles 1975). Immunoglobulins are present in high concentrations in colostrum, with IgG 1 being the predominant immunoglobulin, as shown in Box 2 (Godden 2008).…”

Section: Development Of the Immune Systemmentioning

confidence: 99%

Calf immunology and the role of vaccinations in dairy calves

Sherwin¹,

Down²

2018

In Practice

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The risk of mortality and morbidity in calves is highest during the first few weeks of life. The main causes of mortality change throughout the preweaning period: septicaemia is most likely to occur in neonatal calves (up to 28 days of age); diarrhoea in calves less than 30 days old, and bovine respiratory disease in dairy calves more than 30 days old (McGuirk 2008). During this critical period, many producers look to vaccination and other preventive interventions to minimise the risk of disease. This article discusses the role of vaccinations in the rearing of dairy calves, alongside other preventive measures, and considers the immunological changes that occur during the first few weeks of a calf’s life that are intrinsically linked with risk of morbidity and subsequent mortality in calves.

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Antibody responses to neonatal immunisation in calves

Cited by 79 publications

References 16 publications

Strategies for Design and Application of Enteric Viral Vaccines

Strategies for Design and Application of Enteric Viral Vaccines

Comparison of serum immunoglobulin G half-life in dairy calves fed colostrum, colostrum replacer or administered with intravenous bovine plasma

Calf immunology and the role of vaccinations in dairy calves

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