Antibody Responses to Influenza A/H1N1pdm09 Virus After Pandemic and Seasonal Influenza Vaccination in Healthcare Workers: A 5-Year Follow-up Study

Trieu, Mai-Chi; Jul-Larsen, Åsne; Sævik, Marianne; Madsen, Anders; Nøstbakken, Jane Kristin; Zhou, Fan; Skrede, Steinar

doi:10.1093/cid/ciy487

Cited by 18 publications

(24 citation statements)

References 21 publications

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“…In our study, half of the children and adults were previously vaccinated with adjuvanted pandemic vaccine and these vaccinated subjects had higher MN antibody titres compared to the unvaccinated group, in agreement with previous findings . It has been shown that H1N1pdm09‐specific HI antibodies persist after a single adjuvanted pandemic vaccination beyond the 2012 and 2013 seasons . Interestingly, the adults vaccinated with the pandemic vaccine had significantly higher MN titres than unvaccinated adults, whereas this was not observed in the children many of whom may have had H1N1pdm09 as their first influenza virus infection which circulated in Norway in the 2009/2010 and 2010/2011 seasons (Figure ).…”

Section: Discussionsupporting

confidence: 91%

“…49,50 It has been shown that H1N1pdm09specific HI antibodies persist after a single adjuvanted pandemic vaccination beyond the 2012 and 2013 seasons. 51 Interestingly, the adults vaccinated with the pandemic vaccine had significantly higher MN titres than unvaccinated adults, whereas this was not observed in the children many of whom may have had H1N1pdm09 as their first influenza virus infection which circulated in Norway in the 2009/2010 and 2010/2011 seasons ( Figure S3). In children, influenza imprinting by early exposure to influenza virus influences subsequent influenza immunity, 52,53 but whether the imprinting is specific to the first infection, or a result of the cumulative effect of repeated exposures and boosting, remains unclear, although a child's first encounter with influenza virus (HA imprinting) has a large impact on future immune status.…”

Section: No Boost In H1n1-specific Mn Antibodies In Children or Adumentioning

confidence: 96%

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Functional immune response to influenza H1N1 in children and adults after live attenuated influenza virus vaccination

et al. 2019

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Influenza virus is a major respiratory pathogen, and vaccination is the main method of prophylaxis. In 2012, the trivalent live attenuated influenza vaccine (LAIV) was licensed in Europe for use in children. Vaccine‐induced antibodies directed against the main viral surface glycoproteins, haemagglutinin (HA) and neuraminidase (NA) play important roles in limiting virus infection. The objective of this study was to dissect the influenza‐specific antibody responses in children and adults, and T cell responses in children induced after LAIV immunization to the A/H1N1 virus. Blood samples were collected pre‐ and at 28 and 56 days post‐vaccination from 20 children and 20 adults. No increase in micro‐neutralization (MN) antibodies against A/H1N1 was observed after vaccination. A/H1N1 stalk‐specific neutralizing and NA‐inhibiting (NI) antibodies were boosted in children after LAIV. Interferon γ‐producing T cells increased significantly in children, and antibody‐dependent cellular‐mediated cytotoxic (ADCC) cell activity increased slightly in children after vaccination, although this change was not significant. The results indicate that the NI assay is more sensitive to qualitative changes in serum antibodies after LAIV. There was a considerable difference in the immune response in children and adults after vaccination, which may be related to priming and previous influenza history. Our findings warrant further studies for evaluating LAIV vaccination immunogenicity.

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Section: Discussionsupporting

confidence: 91%

Section: No Boost In H1n1-specific Mn Antibodies In Children or Adumentioning

confidence: 96%

Functional immune response to influenza H1N1 in children and adults after live attenuated influenza virus vaccination

et al. 2019

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“…Antibodies induced by influenza infection or vaccination are known to wane over time, [9][10][11][12][13] and HI-titers have been suggested to decline faster after vaccination with pandemic vaccines than after infection. [14][15][16] Studying antibody waning is important for understanding the longevity of the maternal antibodies.…”

Section: Introductionmentioning

confidence: 99%

Antibody levels in a cohort of pregnant women after the 2009 influenza A(H1N1) pandemic: Waning and association with self‐reported severity and duration of illness

Tunheim

Laake

Robertson

et al. 2019

Influenza Resp Viruses

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Background A population‐based pregnancy cohort was established in Norway to study potential effects of exposure to the 2009 influenza pandemic or pandemic vaccination during pregnancy. Objectives We studied maternal A(H1N1)pdm09‐specific hemagglutination inhibition ( HI )‐titer levels and waning in women with influenza‐like illness ( ILI ) in pregnancy compared to vaccinated women. Moreover, we studied the association between HI ‐titers and self‐reported severity and duration of ILI . Methods HI ‐titers against the pandemic virus were measured in maternal blood samples obtained at birth, 3‐9 months after exposure, and linked with information about pregnancy, influenza and vaccination from national registries and a cohort questionnaire. Results Among 1821 pregnant women included, 43.7% were unvaccinated and 19.3% of these had ILI . HI ‐titers were low (geometric mean titer ( GMT ) 11.3) in the unvaccinated women with ILI . Higher HI ‐titers ( GMT 37.8) were measured in the vaccinated women. Estimated HI ‐titer waning was similar for vaccinated women and women with ILI . Most ILI episodes were moderate and lasted 3‐5 days. Women with ILI reporting specific influenza symptoms such as fever or cough had higher HI ‐titers than women without these symptoms. Women who reported being “very ill” or illness duration of >5 days had higher HI ‐titers than women reporting less severe illness or illness of shorter duration, respectively. Conclusions Antibody waning was similar in vaccinated women and women with ILI . More severe ILI or longer duration of illness was associated with higher HI ‐titers. Most unvaccinated pregnant women with ILI had low HI ‐titers, probably due to moderate illness and HI ‐titer waning between exposure and sampling.

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“…Also, we found a similar pattern of HAI titre or avidity of IgG antibody www.nature.com/scientificreports www.nature.com/scientificreports/ in all individuals or only in influenza-vaccinated individuals. Trieu and colleagues suggested that a history of influenza vaccination was a confounding factor for high baseline antibody titres and affected fold-changes in antibody levels 32 . This conflicting finding could be attributed to the low numbers of individuals with T2DM who did not undergo seasonal vaccination with TIV in the previous year, and the very low numbers of people without T2DM who previously underwent seasonal vaccination with TIV.…”

Section: Discussionmentioning

confidence: 99%

“…This finding implied that T2DM significantly decreased responses against H1N1 and H3N2. A recent study indicated that a history of influenza vaccination is a confounding factor for high baseline antibody titres and affects antibody fold-change 32 . To exclude such factors, we chose only those individuals who received an influenza vaccination in the recent year to analyse and compare the HAI titre at baseline, and we compared the HAI fold-change at day 90 with that at baseline ( Supplementary Fig.…”

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confidence: 99%

Metformin-induced suppression of IFN-α via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes

Saenwongsa

Nithichanon

Chittaganpitch

et al. 2020

Sci Rep

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Diabetes mellitus (DM) patients are at an increased risk of complications following influenza-virus infection, seasonal vaccination (SV) is recommended. However, SV with trivalent influenza vaccine (TIV) can induce antibody and type-I interferon (IFN) responses, and the effect of anti-DM treatment on these responses is incompletely understood. We evaluated the antibody response and IFN-α expression in individuals with and without type 2 DM (T2DM) following SV, and examined the effects on anti-DM treatment. TIV elicited sero-protection in all groups, but antibody persistency was <8 months, except for the antibody response to B-antigens in non-DM. T2DM impaired the IgG avidity index, and T2DM showed a significantly decreased response against H1N1 and H3N2, in addition to delaying and reducing haemagglutination-inhibition persistency against influenza B-antigens in DM groups treated with metformin (Met-DM) or glibenclamide (GB-DM). Following TIV, the Met-DM and GB-DM groups exhibited reduced IFN-α expression upon stimulation with whole-and split-virion influenza vaccines. Suppression of IFN-α expression in the Met-DM group was associated with a reduction in the mechanistic target of rapamycin complex-1 pathway and impaired IgG avidity index. Thus, single-dose TIV each year might not be suitable for T2DM. Our data could aid the development of an efficacious influenza vaccine for T2DM. The prevalence of type-2 diabetes mellitus (T2DM) is increasing worldwide, particularly in developing countries. In 2017, it was estimated that 451 million people worldwide were living with DM, and this number is expected to increase to 693 million by 2045 1. Due to multiple impairments of the immune system, patients with DM are more susceptible to infections such as influenza virus infection 2,3. Annual influenza vaccination is recommended by the World Health Organization (WHO) and the Advisory Committee on Immunization Practices in the USA to prevent influenza infection 4. The efficacy of vaccination should be evaluated in patients with T2DM, who are classified as a high-risk group for influenza infection 2,5,6. Interestingly, it has been reported that anti-DM medications further impair immune responses 7-10. Metforminthe first-line anti-hyperglycaemic drug for T2DM in Thailand-has been reported to impair the immune response by upregulating the expression of 5′ adenosine monophosphate-activated protein kinases (AMPKs) and inhibiting the mechanistic target of rapamycin (mTOR)-mediated pathway 11,12. Glibenclamide is another anti-hyperglycaemic agent that has been reported to impair immune responses by decreasing the production of interleukin (IL)-1β and IL-8 and decreasing glutathione levels in polymorphonuclear cells 13. Furthermore,

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Antibody Responses to Influenza A/H1N1pdm09 Virus After Pandemic and Seasonal Influenza Vaccination in Healthcare Workers: A 5-Year Follow-up Study

Abstract: Pandemic vaccination elicited durable antibodies, supporting the incorporation of adjuvant. Our findings support the current recommendation of annual influenza vaccination in HCWs.

Cited by 18 publications

References 21 publications

Functional immune response to influenza H1N1 in children and adults after live attenuated influenza virus vaccination

Functional immune response to influenza H1N1 in children and adults after live attenuated influenza virus vaccination

Antibody levels in a cohort of pregnant women after the 2009 influenza A(H1N1) pandemic: Waning and association with self‐reported severity and duration of illness

Metformin-induced suppression of IFN-α via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes

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