Antibody Responses to Hemodialysis‐Related Antigens in Chronic Hemodialysis Patients

Dolovich, J.; Evans, Susan; Baurmeister, U.; Schulze, H.; Ali, Mir Wasif; Shimizu, Arthur

doi:10.1111/j.1525-1594.1987.tb02636.x

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…Diagnosis of EtO‐mediated anaphylaxis is generally based upon history and serology, i.e. quantification of a commercially available EtO‐specific IgE, basophil activation tests and skin tests (8, 15, 19, 21, 22, 28–30).…”

Section: Aetiologymentioning

confidence: 99%

Haemodialysis‐associated anaphylactic and anaphylactoid reactions

Ebo

Bosmans²,

Couttenye³

et al. 2006

Allergy

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Anaphylactic and anaphylactoid reactions related to haemodialysis have been increasingly described for almost 3 decades. The majority of these cases used to occur with ethylene oxide sterilized, and complement‐activating cellulose membranes. However, a considerable number of publications have focused on polyacrylonitrile AN69® high flux membranes, angiotensin converting enzyme inhibitors and iron as other important causes of potentially severe haemodialysis‐related anaphylactoid reactions. Clinical manifestations vary considerably and generally do not allow differentiation between IgE‐mediated anaphylaxis and anaphylactoid reactions (e.g. from nonspecific mediator release). Successful management of these patients requires multidisciplinary approach and involves prompt recognition and treatment by the attending physician, and identification of the offending agent(s) with subsequent avoidance of the incriminated compound(s). This review focuses on some major causes of anaphylactoid and anaphylactic reactions during haemodialysis. Special consideration is given to the therapeutic and diagnostic approach.

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Section: Aetiologymentioning

confidence: 99%

Haemodialysis‐associated anaphylactic and anaphylactoid reactions

Ebo

Bosmans²,

Couttenye³

et al. 2006

Allergy

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“…At the conclusion of the re-use study, participants had serum IgG antibodies to formaldehyde-human serum albumin levels determined by Dolovich et al [35]. There was no difference between a normal control population, control hemodialysis patients not exposed to re-use and the study participants.…”

Section: Discussionmentioning

confidence: 99%

“…Adverse effects attributed to formaldehyde include increased hemolysis [32] and renal allograft wastage [33] mediated by anti-N-like antibodies [34], Dolovich et al [35] have reported that the anti-N-like antibody, impli cated in hemolysis and graft rejection, had the same specificity as an IgG antibody to formaldehyde-human serum albumin with respect to hemagglutination of for maldehyde-treated group 0; N-positive red blood cells. At the conclusion of the re-use study, participants had serum IgG antibodies to formaldehyde-human serum albumin levels determined by Dolovich et al [35].…”

Section: Discussionmentioning

confidence: 99%

Dialyzer Re-Use – A Multiple Crossover Study with Random Allocation to Order of Treatment

Churchill

Taylor²,

Shimizu³

et al. 1988

Nephron

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A multiple crossover research study was used to evaluate the effect of dialyzer re-use on fever, blood leaks, serum urea and creatinine values and symptoms. Each of 6 crossover periods consisted of 4 weeks on either single-use or re-use, 1 week washout, 4 weeks on the alternative treatment and 1 week washout. The re-use consisted of 6 uses of each dialyzer and the washout weeks consisted of 3 single-use sessions. Analysis of paired observations within rather than between patients showed no effects of time (i.e. among crossover periods 1 through 6) or number of re-uses (i.e. among uses 1 through 6). There was no significant difference for temperature change during dialysis, blood leak rate, or the serum urea and creatinine values before the first dialysis of each washout period. There were no differences for symptoms of pruritis, cramps, nausea, headache, chest pain, backache or fatigue. There were no clinical advantages or disadvantages associated with dialyzer re-use.

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“…It has been reported that specific formaldehyde antibodies may react with erythrocytes, inducing chronic hemolysis. 19 Accordingly, washing and very sensible formaldehyde testing should be performed on arterial allografts in order to prevent such risk.…”

Section: What Potential Problems Can Be Anticipated From Implantation Of Preserved Arterial Allografts?mentioning

confidence: 99%

Formaldehyde-fixed arterial allograft as a novel vascular access alternative in end-stage renal disease patients

Canaud¹

2007

Kidney International

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Liu and co-workers report on a preliminary study with formaldehyde-fixed arterial allografts. In this way they provide a novel alternative for solving the problem of failing to achieve vascular access in hemodialysis patients. Formaldehyde fixation offers an effective way of reducing the antigenicity of heterologous arterial allograft. Preliminary clinical experience shows that technical survival of such preserved arterial allograft appears quite promising. Further studies will help to define the place of this allograft material in vascular access management of ESRD patients.

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Antibody Responses to Hemodialysis‐Related Antigens in Chronic Hemodialysis Patients

Cited by 5 publications

References 16 publications

Haemodialysis‐associated anaphylactic and anaphylactoid reactions

Haemodialysis‐associated anaphylactic and anaphylactoid reactions

Dialyzer Re-Use – A Multiple Crossover Study with Random Allocation to Order of Treatment

Formaldehyde-fixed arterial allograft as a novel vascular access alternative in end-stage renal disease patients

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