Antibody responses in New World camelids with tuberculosis caused by Mycobacterium microti

Lyashchenko, Konstantin P.; Greenwald, Rena; Esfandiari, Javan; Meylan, Mireille; Burri, I. Hengrave; Zanolari, Patrik

doi:10.1016/j.vetmic.2007.05.026

Cited by 34 publications

(48 citation statements)

References 31 publications

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“…Alpacas 1 and 2 showed a combination of both nodular and diffuse patterns of TB in lungs and trachea together with ulceration of the mucosa and numerous AFB. Similar lesions have been previously reported in alpacas, other camelid species, and wild ruminants (3,14,16,21,22). On the other side, alpaca 3, which was also infected by M. bovis, showed miliary TB lining the pleural and peritoneal cavities with scarce AFB.…”

Section: Herdsupporting

confidence: 87%

“…Camelids are known to be susceptible to MTC, including M. tuberculosis, M. bovis, and/or Mycobacterium microti (8,17,23), and to Mycobacterium kansasii infections (11). Furthermore, TB cases have been recently reported in alpacas and llamas from different European countries (2,14,16,20).…”

Section: Herdmentioning

confidence: 99%

“…The intradermal tuberculin test, which is the traditional diagnostic approach for a number of other species, is believed to produce nonspecific reactions in camelids (6,8,20). Serological assays may be a promising alternative, but little is known about antibody responses during TB in these species (14,23). There have been previous attempts to develop alternative immunodiagnostic assays for TB in camelids based on in vitro lymphocyte transformation or antibody measuring by enzyme-linked immunosorbent assay (ELISA) (10), but no reliable test is currently available.…”

Section: Herdmentioning

confidence: 99%

“…Furthermore, there is little evidence that detection of specific antibodies (using methods such as ELISA) could be a useful indicator of field infection (4). Recently, multiantigen print immunoassay (MAPIA) and lateral-flow-based rapid test (RT) have been experimentally showed as useful diagnostic tools for antemortem detection of TB in multiple host species, including camelids (6,14,23).…”

Section: Herdmentioning

confidence: 99%

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Tuberculosis in Alpacas ( Lama pacos ) Caused by Mycobacterium bovis

et al. 2010

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We report three cases of tuberculosis in alpacas from Spain caused by Mycobacterium bovis. The animals revealed two different lesional patterns. Mycobacterial culture and PCR assay yielded positive results for M. bovis. Molecular typing of the isolates identified spoligotype SB0295 and identical variable-number tandem repeat (VNTR) allele sizes. CASE REPORT Herd 1. The affected herd comprised 32 alpacas (26 adults and six juveniles) and was located in the Ronda region (southern Spain). The animals were raised in outdoor facilities and were fed with commercial pellet feed, hay, and water ad libitum. In March 2009, a 7-year-old female alpaca (alpaca 1) showed dyspnea, fever, depression, lethargy, anorexia, and weight loss. One month later, an 8-year-old male alpaca (alpaca 2) presented chronic weight loss, bruxism, and dyspnea.

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Section: Herdsupporting

confidence: 87%

Section: Herdmentioning

confidence: 99%

Section: Herdmentioning

confidence: 99%

Section: Herdmentioning

confidence: 99%

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Tuberculosis in Alpacas ( Lama pacos ) Caused by Mycobacterium bovis

et al. 2010

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“…Although it is generally recognized that humoral immunity is not important for the 10 control of TB (Raja, 2004), IL-4 induced antibody response against M. bovis may be important for bTB control in wild boar and may be used for disease surveillance and treatment monitoring (Lyashchenko et al, 2007;Lyashchenko et al, 2006;Naranjo et al, 2007a;Waters et al, 2006). In contrast, the increase in IL-4 levels in humans correlates with disease severity (Seah and Rook, 2001), a fact that may underline the 15 existence of host-specific responses to mycobacterial infection that vary between species (Naranjo et al, 2007a).…”

mentioning

confidence: 99%

Expression of immunoregulatory genes in peripheral blood mononuclear cells of European wild boar immunized with BCG

Lastra

Galindo

Gortázar

et al. 2009

Veterinary Microbiology

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1

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Comparative assessment of postmortem inspection and immunochromatographic techniques for the detection of bovine tuberculosis in slaughter cattle in Nigeria

Okoro

Anosa

Oboegbulem

et al. 2014

Trop Anim Health Prod

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Animals with tuberculosis pose some risks to humans, especially in developing countries of the world. In this study, postmortem inspection (PMI) and immunochromatographic assay (ICA) techniques were compared for the detection of bovine tuberculosis (BTB) in slaughter cattle in Enugu State, Nigeria using culture as the gold standard. A cross-sectional study was conducted from January-June, 2011 on animals presented at four purposively selected slaughterhouses in the study area, involving a total of 500 randomly selected animals. Blood samples were collected from the jugular veins of selected animals and serum samples harvested for ICA. Thorough PMI was carried out and tissue samples from the lung, liver, intestine, and lymph nodes were collected, with or without lesions for culture; from the animals examined, culture detected 11 positive cases giving a prevalence rate of 2.2 %, whereas PMI detected 22 positive cases including 7 (out of the 11) positive cases detected by culture, giving a prevalence rate of 4.4 %. Fifteen of the cases detected as positive by PMI were negative by culture. Therefore, the sensitivity and specificity of PMI were 64 and 97 %, respectively. ICA detected 59 positive cases including 10 of the 11 positive cases detected by culture, hence, a prevalence rate of 11.8 %. Forty-nine of the cases detected as positive by ICA were negative by culture. Hence, the sensitivity and specificity of ICA were 91 and 90 %, respectively. In conclusion, the performance of ICA was found sufficiently high to support its use in BTB surveillance and control in cattle in Enugu State, Nigeria.

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Antibody responses in New World camelids with tuberculosis caused by Mycobacterium microti

Cited by 34 publications

References 31 publications

Tuberculosis in Alpacas ( Lama pacos ) Caused by Mycobacterium bovis

Tuberculosis in Alpacas ( Lama pacos ) Caused by Mycobacterium bovis

Expression of immunoregulatory genes in peripheral blood mononuclear cells of European wild boar immunized with BCG

Comparative assessment of postmortem inspection and immunochromatographic techniques for the detection of bovine tuberculosis in slaughter cattle in Nigeria

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