Antibody responses inKlebsiella pneumoniaebloodstream infection: a cohort study
Wontae Hwang,
Paeton L. Wantuch,
Biana Bernshtein
et al.
Abstract:Background: Klebsiella pneumonia (Kpn) is the fourth leading cause of infection-related deaths globally, yet little is known about human antibody responses to invasive Kpn. In this study, we sought to determine whether the O-specific polysaccharide (OPS) antigen, a vaccine candidate, is immunogenic in humans with Kpn bloodstream infection (BSI). We also sought to define the cross-reactivity of human antibody responses among structurally related Kpn OPS subtypes and to assess the impact of capsule production on… Show more
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