Antibody Response to Long‐term and High‐dose Mould‐exposed Sawmill Workers

Rydjord, B.; Eduard, Wijnand; Stensby, Berit A.; Sandven, Per; Michaelsen, T. E.; Wiker, Harald G.

doi:10.1111/j.1365-3083.2007.02022.x

Cited by 13 publications

(6 citation statements)

References 32 publications

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“…The latter finding is in line with a previous study which showed that mould-exposed sawmill workers with the highest exposure had the lowest levels of sIgE 37. This finding may probably be explained by the healthy worker effect.…”

Section: Discussionsupporting

confidence: 92%

Effects of bioaerosol exposure on respiratory health in compost workers: a 13-year follow-up study

et al. 2016

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Section: Discussionsupporting

confidence: 92%

Effects of bioaerosol exposure on respiratory health in compost workers: a 13-year follow-up study

et al. 2016

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“…However, reports on R. microsporus-related infections are relatively uncommon compared with reports on infections related to other Rhizopus species. It has been associated with moldy lumber, as evidenced by the presence of serological responses to Rhizopus species among sawmill workers (37,38). It has also been found in the wooden material used for patient care.…”

Section: Discussionmentioning

confidence: 99%

Outbreak of Intestinal Infection Due to Rhizopus microsporus

Cheng

Chan²,

Ngan³

et al. 2009

J Clin Microbiol

117

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Sinopulmonary and rhinocerebral zygomycosis has been increasingly found in patients with hematological malignancies and bone marrow transplantation, but intestinal zygomycosis remains very rare in the literature. We investigated an outbreak of intestinal infection due to Rhizopus microsporus in 12 patients on treatment for hematological malignancies over a period of 6 months in a teaching hospital. The intake of allopurinol during hospitalization (P < 0.001) and that of commercially packaged ready-to-eat food items in the preceding 2 weeks (P < 0.001) were found to be independently significant risk factors for the development of intestinal zygomycosis. A total of 709 specimens, including 378 environmental and air samples, 181 food samples, and 150 drug samples, were taken for fungal culture. Among them, 16 samples of allopurinol tablets, 3 prepackaged ready-to-eat food items, and 1 pair of wooden chopsticks were positive for Rhizopus microsporus, which was confirmed by ITS1-5.8S-ITS2 rRNA gene cluster (internal transcribed spacer [ITS]) sequencing. The mean viable fungal counts of allopurinol obtained from wards and pharmacy were 4.22 ؋ 10 3 CFU/g of tablet (range, 3.07 ؋ 10 3 to 5.48 ؋ 10 3 ) and 3.24 ؋ 10 3 CFU/g of tablet (range, 2.68 ؋ 10 3 to 3.72 ؋ 10 3 ), respectively, which were much higher than the mean count of 2 ؋ 10 2 CFU/g of food. Phylogenetic analysis by ITS sequencing showed multiple clones from isolates of contaminated allopurinol tablets and ready-to-eat food, of which some were identical to patients' isolates, and with one isolate in the cornstarch used as an excipient for manufacture of this drug. We attempted to type the isolates by random amplification of polymorphic DNA analysis, with limited evidence of clonal distribution. The primary source of the contaminating fungus was likely to be the cornstarch used in the manufacturing of allopurinol tablets or ready-to-eat food. Rhizopus microsporus is thermotolerant and can multiply even at 50°C. The long holding time of the intermediates during the manufacturing process of allopurinol amplified the fungal load. Microbiological monitoring of drugs manufactured for highly immunosuppressed patients should be considered.Zygomycosis has become an important emerging infection in patients with hematological malignancy undergoing chemotherapy or bone marrow transplantation (24), especially with the availability of voriconazole as antifungal prophylaxis (25,28,44). Breakthrough zygomycosis in patients on voriconazole prophylactic treatment is usually manifested as sinopulmonary or rhinocerebral disease, since the fungal spores are ubiquitously found in the environment and could therefore be acquired through inhalation or traumatic inoculation through the skin or mucosa. Gastrointestinal zygomycosis has been a rare clinical entity (50, 54), but cases or outbreaks of tongue, gastric, or cutaneous zygomycosis due to Rhizopus microsporus after exposure to contaminated wooden tongue depressors have been reported (23,26,33).The Rhizopus microsporus species gr...

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“…Antenatal administration of the drug betamethasone was associated with an increase in UCB of retinol-binding protein, transthyretin, and transferrin (Georgieff et al 1988). Increased levels of IgG were found to be associated with a range of environmental exposures—for example, to mold (Rydjord et al 2007), organochlorines (Karmaus et al 2005), tobacco-smoke products (Colquhoun et al 2009), and methylmercury (Nyland et al 2011). …”

Section: Discussionmentioning

confidence: 99%

Prioritization of Biomarker Targets in Human Umbilical Cord Blood: Identification of Proteins in Infant Blood Serving as Validated Biomarkers in Adults

Hansmeier

Chao

Goldman

et al. 2012

Environ Health Perspect

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Background: Early diagnosis represents one of the best lines of defense in the fight against a wide array of human diseases. Umbilical cord blood (UCB) is one of the first easily available diagnostic biofluids and can inform about the health status of newborns. However, compared with adult blood, its diagnostic potential remains largely untapped.Objectives: Our goal was to accelerate biomarker research on UCB by exploring its detectable protein content and providing a priority list of potential biomarkers based on known proteins involved in disease pathways.Methods: We explored cord blood serum proteins by profiling a UCB pool of 12 neonates with different backgrounds using a combination of isoelectric focusing and liquid chromatography coupled with matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI-MS/MS) and by comparing results with information contained in metabolic and disease databases available for adult blood.Results: A total of 1,210 UCB proteins were identified with a protein-level false discovery rate of ~ 5% as estimated by naïve target-decoy and MAYU approaches, signifying a 6-fold increase in the number of UCB proteins described to date. Identified proteins correspond to 138 different metabolic and disease pathways and provide a platform of mechanistically linked biomarker candidates for tracking disruptions in cellular processes. Moreover, among the identified proteins, 38 were found to be approved biomarkers for adult blood.Conclusions: The results of this study advance current knowledge of the human cord blood serum proteome. They showcase the potential of UCB as a diagnostic medium for assessing infant health by detection and identification of candidate biomarkers for known disease pathways using a global, nontargeted approach. These biomarkers may inform about mechanisms of exposure–disease relationships. Furthermore, biomarkers approved by the U.S. Food and Drug Administration for screening in adult blood were detected in UCB and represent high-priority targets for immediate validation.

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Antibody Response to Long‐term and High‐dose Mould‐exposed Sawmill Workers

Cited by 13 publications

References 32 publications

Effects of bioaerosol exposure on respiratory health in compost workers: a 13-year follow-up study

Effects of bioaerosol exposure on respiratory health in compost workers: a 13-year follow-up study

Outbreak of Intestinal Infection Due to Rhizopus microsporus

Prioritization of Biomarker Targets in Human Umbilical Cord Blood: Identification of Proteins in Infant Blood Serving as Validated Biomarkers in Adults

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