Antibody response to GD3 ganglioside is independent of NKT cells

Je, Park Jung; Sx, Lu; Dy, Wu; Prendes, Maria J.; Pb, Chapman

doi:10.1080/14653240701762380

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Previous findings in GBS show that anti-GM1 and anti-GT1a antibodies are predominantly IgG1 and IgG3 ( 30 ) and anti-GQ1b can either be IgG2 or IgG3, depending on the clinical manifestation ( 31 ). However, it has been described that the antibody response to GD3 in general is made of different subclasses of antibodies ( 32 ), these data are in line with our findings for adult acutely infected individuals. The demonstration that the infection yields increased levels of IgG4 during pregnancy is relevant since IgG4 autoimmune antibodies against different antigens are found in various autoimmune diseases and neurological disorders, including GBS ( 33 , 34 ).…”

Section: Discussionsupporting

confidence: 93%

Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection

et al. 2018

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Zika virus (ZIKV) disease has become a global health emergency with devastating effects on public health. Recent evidences implicate the virus as an emergent neuropathological agent promoting serious pathologies of the human nervous system, that include destructive and malformation consequences such as development of ocular and fetal brain lesions, microcephaly in neonates, and Guillain–Barré syndrome (GBS) in adults. These neurological disorders of both central and peripheral nervous systems are thought to be associated to the neurotropic properties of the virus that has ability to infect neural stem cells as well as peripheral neurons, a hallmark of its pathogenicity. The presence of autoantibodies against gangliosides plays a pivotal role in the etiogenesis of GBS and a variety of neurological disorders. Gangliosides are a class of galactose-containing cerebrosides mainly expressed in nervous system tissues playing a critical role in the physiology of neural cells and neurogenesis. Herein, our findings indicate that patients at acute phase of ZIKV infection without any neurological signs show increased levels of IgG autoantibody against GD3 gangliosides, a class of glycolipid found to be highly expressed in neural stem cell acting in the maintenance of their self-renewal cellular capacity. It is possible that a pathological threshold of these antibodies is only acquired in secondary or subsequent infections. In the light of these evidences, we propose that the target of GD3 by autoimmune responses may possibly has an effect in the neuropathy and neurogenesis disorder seen during ZIKV infection.

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Section: Discussionsupporting

confidence: 93%

Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection

et al. 2018

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The cancer glycocode as a family of diagnostic biomarkers, exemplified by tumor-associated gangliosides

Nejatie,

Yee,

Jeter

et al. 2023

Front. Oncol.

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One unexploited family of cancer biomarkers comprise glycoproteins, carbohydrates, and glycolipids (the Tumor Glycocode).A class of glycolipid cancer biomarkers, the tumor-marker gangliosides (TMGs) are presented here as potential diagnostics for detecting cancer, especially at early stages, as the biological function of TMGs makes them etiological. We propose that a quantitative matrix of the Cancer Biomarker Glycocode and artificial intelligence-driven algorithms will expand the menu of validated cancer biomarkers as a step to resolve some of the challenges in cancer diagnosis, and yield a combination that can identify a specific cancer, in a tissue-agnostic manner especially at early stages, to enable early intervention. Diagnosis is critical to reducing cancer mortality but many cancers lack efficient and effective diagnostic tests, especially for early stage disease. Ideal diagnostic biomarkers are etiological, samples are preferably obtained via non-invasive methods (e.g. liquid biopsy of blood or urine), and are quantitated using assays that yield high diagnostic sensitivity and specificity for efficient diagnosis, prognosis, or predicting response to therapy. Validated biomarkers with these features are rare. While the advent of proteomics and genomics has led to the identification of a multitude of proteins and nucleic acid sequences as cancer biomarkers, relatively few have been approved for clinical use. The use of multiplex arrays and artificial intelligence-driven algorithms offer the option of combining data of known biomarkers; however, for most, the sensitivity and the specificity are below acceptable criteria, and clinical validation has proven difficult. One strategic solution to this problem is to expand the biomarker families beyond those currently exploited. One unexploited family of cancer biomarkers comprise glycoproteins, carbohydrates, and glycolipids (the Tumor Glycocode). Here, we focus on a family of glycolipid cancer biomarkers, the tumor-marker gangliosides (TMGs). We discuss the diagnostic potential of TMGs for detecting cancer, especially at early stages. We include prior studies from the literature to summarize findings for ganglioside quantification, expression, detection, and biological function and its role in various cancers. We highlight the examples of TMGs exhibiting ideal properties of cancer diagnostic biomarkers, and the application of GD2 and GD3 for diagnosis of early stage cancers with high sensitivity and specificity. We propose that a quantitative matrix of the Cancer Biomarker Glycocode and artificial intelligence-driven algorithms will expand the menu of validated cancer biomarkers as a step to resolve some of the challenges in cancer diagnosis, and yield a combination that can identify a specific cancer, in a tissue-agnostic manner especially at early stages, to enable early intervention.

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Antibody response to GD3 ganglioside is independent of NKT cells

Cited by 2 publications

References 25 publications

Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection

Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection

The cancer glycocode as a family of diagnostic biomarkers, exemplified by tumor-associated gangliosides

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