Antibody response to central and peripheral nerve antigens in rat and guinea-pig

Cellular Hypersensitivity to Basic Myelin (P2) Protein in the Guillain-Barré Syndrome

“…Early attempts to characterize the neuritogenic component of peripheral nerve were largely unsuccessful. Using PNS basic protein extracts similar to preparations of encephalitogenic factor, Caspary et al (1965) failed to produce experimental disease. Crude pHj extracts prepared by Kies, although producing PNS lesions in guinea pigs, did not produce typical EAN (Sheremata and Behan, 1973).…”

Relationships between Antibodies and Experimental Allergic Encephalomyelitis

“…Since hemagglutination occurs especially with IgM and precipitation with IgG [26,34], the exceptions arc more easily under stood than the general correlation. Although precipitins in gel have been reported by others [9,11,22,25,27,28], without such a quantitative guide it would not have been easy to recognize that one of the problems in adapting immunologic technics to EAE was the relatively short dura tion of the antibody response to a single course of immunization ( fig. 2 and 3).…”

Relationships between Antibodies and Experimental Allergic Encephalomyelitis

“…The evidence for circulating antibodies reported by most investigators was obtained with heterologous antigens used to evoke demyelinating antibodies [6,7], hemagglutinating antibodies [12], non-precipita ting antibodies [13,23], PCA-reacting antibodies [45,51] and gelprecipitating antibodies [4,[15][16][17]49,50]. Some investigators [15,49] used purified preparations of heterologous BP and found no evi dence of species specific contaminants, but they had no homologous antigens for comparison.…”