2005
DOI: 10.1016/j.virol.2005.06.028
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Antibody response is required for protection from Theiler's virus-induced encephalitis in C57BL/6 mice in the absence of CD8+ T cells

Abstract: Intracerebral infection of susceptible mice with Theiler's murine encephalomyelitis virus (TMEV) induces immune-mediated demyelinating disease and this system serves as a relevant infectious model for human multiple sclerosis. It was previously shown that beta2M-deficient C57BL/6 mice lacking functional CD8+ T cells display increased viral persistence and enhanced susceptibility to TMEV-induced demyelination, and yet the majority of mice are free of clinical signs. To understand the mechanisms involved in this… Show more

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Cited by 19 publications
(33 citation statements)
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“…The importance of CD8 ϩ T cells in viral resolution is consistent with previous reports of mice with resistant backgrounds (38,45,47). However, it is also possible that deficiencies in virus-specific CD4 ϩ T-cell and antibody responses in P1-Tg mice contribute to the lack of viral clearance, as these immune responses play a role in TMEV clearance from the CNS, especially during the early stages of viral infection (6,22,40,43). Surprisingly, however, TMEV-infected B6 P1-Tg mice with high levels of viral persistence developed neither symptomatic disease nor demyelinating lesions as late as 250 days pi (Fig.…”
Section: Most Epitopes Recognized By Cns-infiltrating Cd4supporting
confidence: 89%
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“…The importance of CD8 ϩ T cells in viral resolution is consistent with previous reports of mice with resistant backgrounds (38,45,47). However, it is also possible that deficiencies in virus-specific CD4 ϩ T-cell and antibody responses in P1-Tg mice contribute to the lack of viral clearance, as these immune responses play a role in TMEV clearance from the CNS, especially during the early stages of viral infection (6,22,40,43). Surprisingly, however, TMEV-infected B6 P1-Tg mice with high levels of viral persistence developed neither symptomatic disease nor demyelinating lesions as late as 250 days pi (Fig.…”
Section: Most Epitopes Recognized By Cns-infiltrating Cd4supporting
confidence: 89%
“…Like the CD8 ϩ T cells, vigorous antiviral CD4 ϩ T-cell responses in the early stages of viral infection also are important in acquiring resistance to TMEV-IDD (40). Furthermore, virus-specific antibody responses are required to confer resistance to TMEV infection, especially in the absence of CD8 ϩ T cells (22). These data suggest that various virusspecific immune responses contribute to viral resolution and/or resistance to TMEV-IDD in B6 mice.…”
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confidence: 89%
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