Antibody Response in Dogs Experimentally Infected withLeishmania infantum:Infection Course Antigen Markers

Carrera, Lucia; Fermín, Maria Luisa; Tesouro, Miguel A.; García, Pilar; Rollán, E.; Gonzalez, J.; Méndez, Susana; Cuquerella, Montserrat; Alunda, José María

doi:10.1006/expr.1996.0018

Cited by 51 publications

(47 citation statements)

References 10 publications

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“…The studies reviewed here imply that dogs are readily infected with ACL, but compared with canine ZVL, 110,112,113,137,138,[141][142][143][167][168][169][170][171][172] little is known about the clinical, parasitologic, and immunologic course of canine ACL infections. Combined with xenodiagnosis studies, this information could identify correlates of infectiousness, enabling putative dog control programs to maximize their effectiveness by focusing on those dogs which are infectious.…”

Section: Can Dogs Be Incriminated As Reservoir Hosts Of Human Acl?mentioning

confidence: 99%

Is the domestic dog (Canis familiaris) a reservoir host of American cutaneous leishmaniasis? A critical review of the current evidence.

Reithinger

Davies²

1999

The American Journal of Tropical Medicine and Hygiene

134

101

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Abstract. Originally associated with forested areas, the transmission cycle of American cutaneous leishmaniasis (ACL) has now adapted to the domestic environment in at least 9 Latin American countries. Several studies have suggested that the domestic dog (Canis familiaris), which is already incriminated as the primary reservoir host of zoonotic visceral leishmaniasis (ZVL), may have a reservoir role in the domestic transmission of human ACL caused by Leishmania braziliensis, L. panamensis, and L. peruviana. This article reviews more than 90 studies reporting ACL infections in dogs, and concludes that as yet there is only circumstantial evidence to support that claim. Almost no data are available on the infectiousness of dogs to sandfly vectors of ACL, and there are few indications that either dog ownership or dog abundance are risk factors for ACL. Nevertheless, it has been proposed that incidence of ACL in humans could be reduced by targeting infected dogs. While this control strategy has been used for many decades against ZVL in Latin America, Europe, and Asia, there is little evidence to demonstrate its effectiveness either in theory or in practice. Particular concerns over the sensitivity and specificity of diagnostic tools, low compliance rates among dog owners, and cost-effectiveness are likely to apply equally to ACL control.The leishmaniases are a group of zoonotic diseases transmitted to humans and animals by the bite of phlebotomine sand flies (Diptera: Psychodidae). Despite their multiple etiologies, the New World leishmaniases can be divided into two broad categories: zoonotic visceral leishmaniasis (ZVL) and American cutaneous leishmaniasis (ACL).1 The latter includes localized cutaneous, mucocutaneous, and diffuse cutaneous leishmaniasis. Whereas ZVL is almost exclusively caused by Leishmania chagasi (L. infantum), ACL is caused by several Leishmania species, of which L. braziliensis is the most widespread. Many sandfly species have been incriminated as vectors of ACL throughout its geographic range, but reservoir hosts have only been identified for L. amazonensis, L. mexicana, L. guyanensis, and L. panamensis, and are unknown or unproven for both L. braziliensis and L. peruviana. 1 Originally associated with forested areas, 2 the transmission cycle of ACL has now adapted to the domestic environment due to deforestation and urbanization. 3,4 The transition from sylvatic to domestic transmission cycle was further encouraged by the lack of a specific leishmaniasis control strategy, and the discontinuation of intervention campaigns designed for other infectious diseases, e.g., malaria. 5,6

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Section: Can Dogs Be Incriminated As Reservoir Hosts Of Human Acl?mentioning

confidence: 99%

Is the domestic dog (Canis familiaris) a reservoir host of American cutaneous leishmaniasis? A critical review of the current evidence.

Reithinger

Davies²

1999

The American Journal of Tropical Medicine and Hygiene

134

101

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“…Therefore, further studies on the pathogenic mechanisms involved in the GN of VL are needed. Since canine and human VL share similar disease manifestations, dogs represent an appropriate animal model for the human disease (10). In addition, golden hamsters (Mesocricetus auratus) infected with L. donovani or L. chagasi are also considered to be an excellent VL model (11).…”

mentioning

confidence: 99%

“…In addition, golden hamsters (Mesocricetus auratus) infected with L. donovani or L. chagasi are also considered to be an excellent VL model (11). However, their use is limited for immunopathological studies, mainly due to the lack of available antibodies for immunological markers (10). An alternative is to use inbred mouse strains susceptible to L. (L.) chagasi infection.…”

mentioning

confidence: 99%

Leishmania (Leishmania) chagasi-infected mice as a model for the study of glomerular lesions in visceral leishmaniasis

Prianti

Yokoo

et al. 2007

Braz J Med Biol Res

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Renal involvement in visceral leishmaniasis (VL) is very frequent but the pathogenesis of this nephropathy is poorly understood. In previous studies using dogs with VL we have detected new immunopathological elements in the glomeruli such as T cells and adhesion molecules. Although Leishmania (Leishmania) chagasi-infected dogs and hamsters are considered to be good models for VL, their use is limited for immunopathologic studies. The use of isogenic mouse strains susceptible to L. (L.) chagasi infection was an alternative but, on the other hand, the renal lesions of these animals have not yet been characterized. Thus, our purpose in the present study was to characterize mice infected with L. (L.) chagasi as a suitable model to study VL nephropathy. Kidney samples were obtained from control mice (N = 12) and from BALB/c mice (N = 24) injected intraperitoneally with 20 million L. (L.) chagasi amastigotes 7, 15, and 30 days after injection and processed for histopathological studies and detection of IgG deposits. Glomerular hypercellularity was clearly visible and, upon Mason's trichrome and periodic acid methenamine silver staining, a pattern suggestive of mesangial proliferative glomerulonephritis was observed in mice with VL. Time-dependent IgG deposits were also seen in infected mice. We consider L. (L.) chagasi-infected mice to be a suitable model for studies of the immunopathogenesis of glomerular lesions in VL.

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“…It seems that high levels of IgG production were seen in the acute phase of leishmaniasis and pathological reaction incidences (9,12). It was proven that, like human visceral leishmaniasis, canine visceral leishmaniasis is associated with high levels of polyclonal specific IgG (12,13).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of canine anti-Leishmania IgG subclasses and their relation with skin signs in naturally infected dogs in the northwest of Iran

Asl¹,

Sharifi²,

Mohebali³

et al. 2013

Turk J Vet Anim Sci

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Antibody Response in Dogs Experimentally Infected withLeishmania infantum:Infection Course Antigen Markers

Cited by 51 publications

References 10 publications

Is the domestic dog (Canis familiaris) a reservoir host of American cutaneous leishmaniasis? A critical review of the current evidence.

Is the domestic dog (Canis familiaris) a reservoir host of American cutaneous leishmaniasis? A critical review of the current evidence.

Leishmania (Leishmania) chagasi-infected mice as a model for the study of glomerular lesions in visceral leishmaniasis

Evaluation of canine anti-Leishmania IgG subclasses and their relation with skin signs in naturally infected dogs in the northwest of Iran

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