Antibody replacement therapy in primary antibody deficiencies and iatrogenic hypogammaglobulinemia

Abstract

Antibody replacement therapy has been used in the treatment of primary antibody deficiencies (PADs) for several decades, and an evidence-based guideline for its treatment is currently available. By contrast, the use of antibody replacement therapy in iatrogenic hypogammaglobulinemia (IHG), a condition that is associated with immunosuppressive medication, has hardly any evidence base and no guidelines. As IHG can be equally as severe as PAD and is much more prevalent, evidence-based guidelines are urgently needed. This review will focus on the differences and similarities between PAD and IHG and the use of antibody replacement therapy in both conditions. Suggestions for the development of evidence-based guidelines and future research are given.

Treatment of antibody immunodeficiency

“…V případě sekundárních humorálních imunodeficiencí je potřeba zvážit sérovou hladinu imuno globulinů, zejména IgG, závažnost klinicky vyjádřené humorální imunodeficience a předpokládaný přínos substituční terapie. I u těchto nemocných by mělo proběhnout testování specifické imunitní odpovědi [8].…”