Antibody persistence after primary measles-mumps-rubella vaccine and response to a second dose given at four to six vs. eleven to thirteen years

Johnson, Carrie; Kumar, Mary L.; Whitwell, Judy K.; Staehle, Brenda; Rome, Leonard P.; Dinakar, Chitra; Hurni, William M.; Nalin, David R.

doi:10.1097/00006454-199608000-00010

Cited by 80 publications

(43 citation statements)

References 13 publications

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“…Only the result of one study from Saudi Arabia was similar to our study (19). The seroprevalence of measles antibodies in our study in both groups were lower than other studies worldwide (1,4,12,15,20,21).…”

Section: Discussioncontrasting

confidence: 83%

Seroprevalence of measles, mumps and rubella Antibodies in 18 months and 6.5 years old children: 6 months after measles-mumps-rubella (MMR) vaccination

Shamsizadeh

Nikfar

Makvandi

et al. 2012

Jundishapur J Microbiol

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This study determined the level of immunity after MMR vaccination in 18 months and 6 years old children.Background: Mumps, measles and rubella viruses lead to various kinds of complications such as meningoencephalitis, deafness, congenital abnormalities and even cause mortality in malnourished patients,. Since 2004, MMR vaccination in two series of one year of age and four to six years has been administered to Iranian children as a part of routine vaccination program. Recently, MMR vaccination schedule has been changed to one year and 18 months series. Objectives: Since MMR vaccine has been recently entered childhood vaccination program, this study was performed to determine immunity response against mumps, measles and rubella six months after one year and four to six years of age vaccination. Patients and Methods:In a cross-sectional study, antibody titers after MMR vaccination at 18 months (six months after dose of one year) in 70 children, and at 6.5 years (six month after dose of six years) in 90 children referred to Ahvaz Abuzar Children's Hospital Vaccination Clinic during 2007-2008 were detected by ELISA method. Results: In 70 children (34 boys and 36 girls) who were vaccinated at one year, 30 (42.9 %) had antibody against measles, 63 (90 %) against rubella and 41 (58.6 %) against mumps. In 90 children (54 boys and 36 girls at 6.5 years of age (six months after vaccination), 41 (45.6%) children had antibody against measles, 79 (87.8 %) against rubella and 69 (76.7%) against mumps. Conclusions: the results of this study showed that after MMR vaccination, the level of antibody for measles was about 45 % and for mumps about 50-80 %. This level of immunity is not acceptable for successful vaccination. while the level of antibody against rubella was sufficient. For better evaluation of MMR vaccination, further studies and from other parts of the country is needed.

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Section: Discussioncontrasting

confidence: 83%

Seroprevalence of measles, mumps and rubella Antibodies in 18 months and 6.5 years old children: 6 months after measles-mumps-rubella (MMR) vaccination

Shamsizadeh

Nikfar

Makvandi

et al. 2012

Jundishapur J Microbiol

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“…[28][29][30][31][32] Specific serum antibody levels for each of these assays was previously shown to correlate with Combination Measles, Mumps, Rubella and Varicella Vaccine (ProQuad ® ) protection against disease; each assay also was shown to correlate with functional antibody assays [33][34][35][36][37] (and unpublished data).…”

Section: Methodsmentioning

confidence: 94%

Safety and Immunogenicity of a Combination: Measles, Mumps, Rubella and Varicella Vaccine (ProQuad®)

Kuter

Brown²,

Hartzel³

et al. 2006

Human Vaccines

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“…Measles antibodies seem to decline in early adulthood if the second MMR-dose is given in early childhood [25]. Rubella antibodies have also been shown to decrease to seronegativity or the lowest detectable titer in over half of MMR recipients in twelve years [26].…”

Section: Discussionmentioning

confidence: 99%

Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015

Koivisto

Puhakka

Lappalainen

et al. 2017

Vaccine

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Antibody persistence after primary measles-mumps-rubella vaccine and response to a second dose given at four to six vs. eleven to thirteen years

Cited by 80 publications

References 13 publications

Seroprevalence of measles, mumps and rubella Antibodies in 18 months and 6.5 years old children: 6 months after measles-mumps-rubella (MMR) vaccination

Seroprevalence of measles, mumps and rubella Antibodies in 18 months and 6.5 years old children: 6 months after measles-mumps-rubella (MMR) vaccination

Safety and Immunogenicity of a Combination: Measles, Mumps, Rubella and Varicella Vaccine (ProQuad®)

Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015

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