Antibody–peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins

Petruzzella, Aaron; Bruand, Marine; Santamaria-Martínez, Albert; Katanayeva, Natalya; Reymond, Luc; Wehrle, Sarah; Georgeon, Sandrine; Inel, Damla; van Dalen, Floris J.; Viertl, David; Lau, Kelvin; Pojer, Florence; Schottelius, Margret; Zoete, Vincent; Verdoes, Martijn; Arber, Caroline; Correia, Bruno E.; Oricchio, Elisa

doi:10.1038/s41589-024-01627-z

Nat Chem Biol

2024

DOI: 10.1038/s41589-024-01627-z

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Antibody–peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins

Aaron Petruzzella,

Marine Bruand,

Albert Santamaria-Martínez

et al.

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Beyond Anticoagulation: A Comprehensive Review of Non-Vitamin K Oral Anticoagulants (NOACs) in Inflammation and Protease-Activated Receptor Signaling

Jannati,

Patnaik,

Banerjee

2024

IJMS

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Non-vitamin K oral anticoagulants (NOACs) have revolutionized anticoagulant therapy, offering improved safety and efficacy over traditional agents like warfarin. This review comprehensively examines the dual roles of NOACs—apixaban, rivaroxaban, edoxaban, and dabigatran—not only as anticoagulants, but also as modulators of inflammation via protease-activated receptor (PAR) signaling. We highlight the unique pharmacotherapeutic properties of each NOAC, supported by key clinical trials demonstrating their effectiveness in preventing thromboembolic events. Beyond their established anticoagulant roles, emerging research suggests that NOACs influence inflammation through PAR signaling pathways, implicating factors such as factor Xa (FXa) and thrombin in the modulation of inflammatory responses. This review synthesizes current evidence on the anti-inflammatory potential of NOACs, exploring their impact on inflammatory markers and conditions like atherosclerosis and diabetes. By delineating the mechanisms by which NOACs mediate anti-inflammatory effects, this work aims to expand their therapeutic utility, offering new perspectives for managing inflammatory diseases. Our findings underscore the broader clinical implications of NOACs, advocating for their consideration in therapeutic strategies aimed at addressing inflammation-related pathologies. This comprehensive synthesis not only enhances understanding of NOACs’ multifaceted roles, but also paves the way for future research and clinical applications in inflammation and cardiovascular health.

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Beyond Anticoagulation: A Comprehensive Review of Non-Vitamin K Oral Anticoagulants (NOACs) in Inflammation and Protease-Activated Receptor Signaling

Jannati,

Patnaik,

Banerjee

2024

IJMS

View full text Add to dashboard Cite

show abstract

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Antibody–peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins

Cited by 1 publication

References 68 publications

Beyond Anticoagulation: A Comprehensive Review of Non-Vitamin K Oral Anticoagulants (NOACs) in Inflammation and Protease-Activated Receptor Signaling

Beyond Anticoagulation: A Comprehensive Review of Non-Vitamin K Oral Anticoagulants (NOACs) in Inflammation and Protease-Activated Receptor Signaling

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