Antibody-mediated Prevention of Fusarium Mycotoxins in the Field

Abstract

Fusarium mycotoxins directly accumulated in grains during the infection of wheat and other cereal crops by Fusarium head blight (FHB) pathogens are detrimental to humans and domesticated animals. Prevention of the mycotoxins via the development of FHB-resistant varieties has been a challenge due to the scarcity of natural resistance against FHB pathogens. Various antibodies specific to Fusarium fungi and mycotoxins are widely used in immunoassays and antibody-mediated resistance in planta against Fusarium pathogens has been demonstrated. Antibodies fused to antifungal proteins have been shown to confer a very significantly enhanced Fusarium resistance in transgenic plants. Thus, antibody fusions hold great promise as an effective tool for the prevention of mycotoxin contaminations in cereal grains. This review highlights the utilization of protective antibodies derived from phage display to increase endogenous resistance of wheat to FHB pathogens and consequently to reduce mycotoxins in field. The role played by Fusarium-specific antibody in the resistance is also discussed. OPEN ACCESSInt. J. Mol. Sci. 2008, 9 1916

Integrated Mycotoxin Management System in the Feed Supply Chain: Innovative Approaches

“…Another innovation field under study is the antibody-mediated technology. It consists of the design of monoclonal and recombinant fungal-specific antibodies expressed by plants, which can reduce the fungal pathogens spread in the field and can decrease the mycotoxin-production load [ 120 ]. Transgenic antibodies have also been studied with positive results.…”