Antibody-mediated Immune Enhancement in Coxsackievirus B3 Myocarditis

Kishimoto, Chiharu; Kurokawa, Mineo; Ochiai, Hiroshi

doi:10.1006/jmcc.2002.2087

Cited by 22 publications

(13 citation statements)

References 30 publications

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“…In cases of successive exposures to coxsackievirus B3 (CVB3), small numbers of antibodies directed against this virus would worsen the CVB3 myocarditis among patients with preexisting anti-CVB3 antibodies, for a partial explanation. In these patients, the ADE of CVB3 infection would predominate over CVB3 neutralization [27]. We demonstrated that subneutralizing antibodies of EV71 bind to it and enhance the virus uptake of Fc receptor-bearing monocytes in vitro [28].…”

Section: Discussionmentioning

confidence: 95%

Reemerging of enterovirus 71 in Taiwan: the age impact on disease severity

Wang

Lin³

et al. 2011

Eur J Clin Microbiol Infect Dis

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Enterovirus 71 (EV71) infection commonly strike children under the age of 3 years, with an occasionally unfavorable outcome in children. This study was designed to explore the relationship between age and the severity of complications, which may associate with antibody-dependent enhancement (ADE) in EV71. All EV71-infected patients during the outbreak of 2008 were recruited. In total, 134 patients were enrolled and categorized into two age groups, 0-12 months (n = 18) and >12 months (n = 116). Pulmonary edema/hemorrhage more commonly occur in patients younger than 12 months. No difference in the occurrence of herpangina/hand-foot-and-mouth disease (HFMD), uncomplicated brainstem encephalitis (BE), or autonomic nervous system (ANS) dysregulation was noted between the two age groups. Patients with pulmonary edema/hemorrhage (11.9 ± 14.7 months) were younger than patients with herpangina/HFMD (35.8 ± 26.4 months) or ANS dysregulation (33.9 ± 20.9 months). Our findings are in agreement with the data regarding the outbreak in Taiwan, in which a decrease in age corresponded to an increase in disease severity with regard to central nervous system complications. A reduction of maternal antibodies to the subneutralizing level within 1 year of age may be associated with the ADE of the infection. This study could provide possible clinical significance with regard to ADE phenomena in young infants infected by EV71.

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Section: Discussionmentioning

confidence: 95%

Reemerging of enterovirus 71 in Taiwan: the age impact on disease severity

Wang

Lin³

et al. 2011

Eur J Clin Microbiol Infect Dis

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“…Indeed, heterologous challenge of mice with CV-B3 after an initial infection with CV-B2 resulted in enhanced pathology 15,16 which especially can be due to the phenomenon of antibody-dependent enhancement. 15,17,18,19,9 Moreover it has been shown that in adult mice homologous challenge with CVB4-E2 resulted in hyperglycaemia, 20 and that challenge of pups of dams infected during pregnancy resulted in enhanced pathology in the offspring through possibly immune-mediated mechanisms due to pre-existing immunity. 21 In conclusion, in vitro assays displayed that serum samples of mice inoculated with CV-B4 E2 had an enhancing effect able to increase, on the one hand, the CV-B4 E2-induced production of antiviral mediators by spleen cells cultures and, on the other hand, the infection of these cells with CV-B4 E2.…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin G-dependent enhancement of the infection with Coxsackievirus B4 in a murine system

et al. 2016

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It was demonstrated that specific IgG can enhance the infection with CV-B4, in vitro, in the human system. This enhancement could be involved in the pathophysiology of CV-B4 induced diseases. To investigate further the role of enhancing IgG in the infection with CV-B4 E2 in vivo, animal models are needed. Therefore, it was decided to assess whether inoculation of CV-B4 E2 to mice results in the appearance of IgG able to enhance the infection with this virus. Swiss albino mice were inoculated with CV-B4 E2 intraperitoneally. Serum samples were obtained from tail vein blood collected from day 0 to day 80 p.i. IgG were isolated by Protein G affinity chromatography. Seroneutralisation assays were carried out. In total murine spleen cells cultures inoculated with CV-B4 E2 mixed with various dilutions of serum or IgG samples, the enhancing activity was assayed through i) the antiviral activity titer of supernatants ii) the detection of intracellular viral RNA by RT-PCR iii) the level of infectious particles in supernatants.In most serum samples (76/105), neutralizing and enhancing activities were detected peaking between days 14 and 30 p.i and were higher in sera from mice inoculated with 2.10 6 TCID50 units than with lower doses. The enhancing activity was due to the IgG-enriched fraction of serum from CV-B4 E2 infected animals but not from control animals.These data show that IgG from immune mice can enhance the infection of splenocytes with CV-B4 E2 in vitro and open the way to explore whether such an enhancing activity can play a role in vivo.

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“…Moreover, Kishimoto et al reported that antibody-mediated immune enhancement is involved in the pathogenesis of CBV3 myocarditis in mice. 18 Nishimura et al also proved that PD-1, which binds to the 33-kD protein, may be an important factor contributing to autoimmune cardiomyopathy in mice. 19 These results raise the possibility that some form of cardiomyopathy may have a CVB3-induced autoimmune basis, and that identifying possible autoantigen(s) may open up new diagnostic and therapeutic approaches for this disease.…”

Section: Discussionmentioning

confidence: 99%