Antibody-mediated depletion of select T cell subsets in blood and tissue of nonhuman primates
Matthew S. Sutton,
Allison N. Bucsan,
Chelsea C. Lehman
et al.
Abstract:Understanding the immunological control of pathogens requires a detailed evaluation of the mechanistic contributions of individual cell types within the immune system. While knockout mouse models that lack certain cell types have been used to help define the role of those cells, the biological and physiological characteristics of mice do not necessarily recapitulate that of a human. To overcome some of these differences, studies often look towards nonhuman primates (NHPs) due to their close phylogenetic relati… Show more
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