Antibody levels in adult patients with coeliac disease during gluten‐free diet: a rapid initial decrease of clinical importance

Midhagen, Gunnar; Åberg, A-K; Olcén, Per; Järnerot, Gunnar; Valdimarsson, Trausti; Dahlbom, Ingrid; Hansson, Tomas; Ström, Magnus

doi:10.1111/j.1365-2796.2004.01406.x

Cited by 49 publications

(39 citation statements)

References 43 publications

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“…In the case of the tTG-Gliad-U condition, we observed only 1 case with persistent high IgA anti-tTG level. These results agree with several reports in which determination of IgA anti-tTG is found to be useful in the follow-up of CD in children [15,20] and adults [22,23], although some authors state that IgA anti-tTG assay is not better than anti-gliadin antibodies (AGA) or anti-endomysium antibodies (EmA) in assessing histologic recovery after GFD and in assessing dietary transgression [24,25].…”

Section: Discussionsupporting

confidence: 76%

Analytical Performance of a New Gliadin-Activated Anti-tTransglutaminase ELISA Test

Galan¹,

Hoyos²,

Cacho³

et al. 2009

TOAUTOJ

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Significant progresses on the anti-tissue transglutaminase antibodies (anti-tTG) ELISA tests have been achieved since anti-tTG early development. Our goal was to study the optimization of the antigen immobilization and the antibody reaction conditions in an ELISA test for the detection of anti-tTG. Hence, three variants of an anti-tTG ELISA test were developed: tTG-Gliad-U, tTG-U and tTG-Gliad, according to the coating conditions (presence/absence of gliadin) and the stringency in the sample buffer (presence/absence of urea). To assess IgA and IgG anti-tTG frequencies we used a group of 117 CD patients, 36 under a gluten-free diet and 14 with a selective IgA deficiency, and a control group of 165 non-celiac patients. Sensitivity of IgA anti-tTG in CD patients with villous atrophy was 95.5% (tTG-Gliad-U), 65.0% (tTG-U) and 92.5% (tTG-Gliad), respectively. Sensitivity of the IgG anti-tTG assay was 79.0%, 21.0% and 79.0%, respectively. Specificities ranged between 92.9% and 100%. Significant lower IgA and IgG concentration values were observed in GFD CD patients. Sensitivity and specificity of IgG anti-tTG in CD patients with selective IgA deficiency were 64.3 and 100%, respectively. In conclusion, we have developed an ELISA test for IgA anti-tTG based on calcium and gliadin activated recombinant human transglutaminase. This test is sensitive and specific, and it is useful to ensure the compliance with diet of CD patients.

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Section: Discussionsupporting

confidence: 76%

Analytical Performance of a New Gliadin-Activated Anti-tTransglutaminase ELISA Test

Galan¹,

Hoyos²,

Cacho³

et al. 2009

TOAUTOJ

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“…15 In addition, various studies have confirmed the tight correlation between serum TGA and grades of villous atrophy, with increasing values consistently representing more severe mucosal lesions. 18,19 This has been elegantly shown in people treated with a gluten-free diet whose TGA levels returned to normal, as did their small bowel mucosa. 18 It is possible that there is some measurement error in both our outcome and exposure variables, yet this is unlikely to be differential for values of TGA and therefore is only likely to have led to an underestimate of the gradients we have described.…”

Section: Discussionmentioning

confidence: 90%

The Iceberg of Celiac Disease: What Is Below the Waterline?

West

Logan

Hill

et al. 2007

Clinical Gastroenterology and Hepatology

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“…It should be noted that both serological screening tests and intestinal biopsy must be done while the individual is consuming gluten, since antibody levels drop rapidly once a gluten-free diet is initiated, often resulting in inconclusive or negative results [47]. In an attempt to improve the diagnosis of celiac disease in a large population of adults in Italy, a program of celiac awareness, targeted to primary care physicians, has been launched [10].…”

Section: Discussionmentioning

confidence: 98%

The Canadian Celiac Health Survey

et al. 2007

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The purpose of this study was to characterize the diagnostic process, frequency of associated disorders, family history, and impact of a gluten-free diet in individuals with celiac disease. All members of the Canadian Celiac Association (n=5240) were surveyed with a questionnaire. Respondents included 2681 adults with biopsy-proven celiac disease. The mean age was 56 years. Most common presenting symptoms included abdominal pain (83%), diarrhea (76%), and weight loss (69%). The mean delay in diagnosis was 11.7 years. Diagnoses made prior to celiac disease included anemia (40%), stress (31%), and irritable bowel syndrome (29%). Osteoporosis was common. Prior to diagnosis, 27% of respondents consulted three or more doctors about their symptoms. Delays in diagnosis of celiac disease remain a problem. Associated medical conditions occur frequently. More accurate food labeling is needed. Improved awareness of celiac disease and greater use of serological screening tests may result in earlier diagnosis and reduced risk of associated conditions.

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Antibody levels in adult patients with coeliac disease during gluten‐free diet: a rapid initial decrease of clinical importance

Cited by 49 publications

References 43 publications

Analytical Performance of a New Gliadin-Activated Anti-tTransglutaminase ELISA Test

Analytical Performance of a New Gliadin-Activated Anti-tTransglutaminase ELISA Test

The Iceberg of Celiac Disease: What Is Below the Waterline?

The Canadian Celiac Health Survey

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